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Title: Tanshinone I as a novel therapeutic agent targeting von Willebrand factor-binding protein to mitigate Staphylococcus aureus pathogenicity

Journal Article · · Virulence
 [1];  [1];  [2];  [2];  [1];  [3];  [3];  [4];  [1]; ORCiD logo [5]
  1. College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
  2. College of Integrated Traditional Chinese and Western Medicine, Changchun University of Chinese Medicine, Changchun, China
  3. Clinical Medical College, Changchun University of Chinese Medicine, Changchun, China
  4. Chinese Medicine Guangdong Laboratory, Hengqin, Guangdong, China, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Jilin University, Changchun, China
  5. Obstetrics and Gynecology Diagnosis and Treatment Center, Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, China

Not Available

Sponsoring Organization:
USDOE
OSTI ID:
2484200
Journal Information:
Virulence, Journal Name: Virulence Journal Issue: 1 Vol. 16; ISSN 2150-5594
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
United States
Language:
English

References (33)

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Staphylococcus aureus bacteremic pneumonia journal January 2016
Bilobetin attenuates Staphylococcus aureus virulence by targeting Von Willebrand factor-binding protein and staphylocoagulase journal October 2023
The role of nasal carriage in Staphylococcus aureus infections journal December 2005
Combination Antimicrobial Treatment Versus Monotherapy: The Contribution of Meta-analyses journal June 2009
Current understanding of plant-derived exosome-like nanoparticles in regulating the inflammatory response and immune system microenvironment journal April 2023
Natural Products That Target Virulence Factors in Antibiotic-Resistant Staphylococcus aureus journal November 2019
Tamarixetin Attenuated the Virulence of Staphylococcus aureus by Directly Targeting Caseinolytic Protease P journal July 2022
In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation journal August 2011
The biology and future prospects of antivirulence therapies journal January 2008
Thwarting resistance: MgrA inhibition with methylophiopogonanone a unveils a new battlefront against S. aureus journal February 2024
Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research journal February 2019
von Willebrand factor-binding protein (vWbp)-activated factor XIII and transglutaminase 2 (TG2) promote cross-linking between FnBPA from Staphylococcus aureus and fibrinogen journal July 2023
Natural products acting against S. aureus through membrane and cell wall disruption journal January 2023
Structure and Function of Staphylothrombin journal October 1994
Von Willebrand factor-binding protein is a hysteretic conformational activator of prothrombin journal May 2009
Marginal role of von Willebrand factor-binding protein and coagulase in the initiation of endocarditis in rats with catheter-induced aortic vegetations journal October 2018
Pathogenicity and virulence of Staphylococcus aureus journal January 2021
Comparison of Virulence in Community‐Associated Methicillin‐ResistantStaphylococcus aureusPulsotypes USA300 and USA400 in a Rat Model of Pneumonia
  • Montgomery, Christopher P.; Boyle‐Vavra, Susan; Adem, Patricia V.
  • The Journal of Infectious Diseases, Vol. 198, Issue 4 https://doi.org/10.1086/590157
journal August 2008
Enzymatic Properties of Staphylothrombin, an Active Molecular Complex Formed between Staphylocoagulase and Human Prothrombin12 journal December 1985
A novel von Willebrand factor binding protein expressed by Staphylococcus aureus a aThe GenBank accession number for the sequence reported in this paper is AY032850. journal July 2002
The von Willebrand factor-binding protein (vWbp) ofStaphylococcus aureusis a coagulase journal May 2004
Staphylococcus aureus , master manipulator of the human hemostatic system journal January 2018
Targeting QseC Signaling and Virulence for Antibiotic Development journal August 2008
Role of coagulase in a murine model of hematogenous pulmonary infection induced by intravenous injection of Staphylococcus aureus enmeshed in agar beads journal February 1997
Staphylococcus aureus Responds to the Central Metabolite Pyruvate To Regulate Virulence journal March 2018
Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood journal October 2011
Methicillin-Resistant Staphylococcus Aureus Nasal Carriers among Laboratory Technical Staff of Tertiary Hospital in Eastern Nepal journal January 2020
The Complex Fibrinogen Interactions of the Staphylococcus aureus Coagulases journal April 2019
Antibodies to coagulase of Staphylococcus aureus crossreact to Efb and reveal different binding of shared fibrinogen binding repeats journal September 2023
Subpopulations in Strains of Staphylococcus aureus Provide Antibiotic Tolerance journal February 2023
Staphylococcus aureus Toxins and Their Molecular Activity in Infectious Diseases journal June 2018
Targeting Staphylococcus aureus Toxins: A Potential form of Anti-Virulence Therapy journal March 2016

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