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Title: Gut microbiota and microbial metabolites for osteoporosis

Journal Article · · Gut Microbes
 [1];  [1];  [1]; ORCiD logo [2]
  1. Department of Orthopaedics, Peking University Third Hospital, Beijing, China
  2. Department of Orthopaedics, Peking University Third Hospital, Beijing, China, Beijing Key Laboratory of Spinal Disease Research, Beijing, China, Engineering Research Center of Bone and Joint Precision Medicine, Beijing, China

Not Available

Sponsoring Organization:
USDOE
OSTI ID:
2482558
Journal Information:
Gut Microbes, Journal Name: Gut Microbes Journal Issue: 1 Vol. 17; ISSN 1949-0976
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
United States
Language:
English

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Fecal microbiota transplantation from young donor mice improves ovarian function in aged mice journal November 2022
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Osteoarthritis induced by destabilization of the medial meniscus is reduced in germ-free mice journal August 2018
Fecal microbiota transplantation ameliorates bone loss in mice with ovariectomy-induced osteoporosis via modulating gut microbiota and metabolic function journal November 2022
Gut dysbiosis aggravates cognitive deficits, amyloid pathology and lipid metabolism dysregulation in a transgenic mouse model of Alzheimer's disease journal December 2023
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FOS/GOS attenuates high-fat diet induced bone loss via reversing microbiota dysbiosis, high intestinal permeability and systemic inflammation in mice journal June 2021
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Estrogen deficiency induces bone loss through the gut microbiota journal October 2023
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Activation of farnesoid X receptor signaling by geniposidic acid promotes osteogenesis journal August 2022
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Dietary Isoquercetin Ameliorates Bone Loss via Restoration of the Gut Microbiota and Lipopolysaccharide-Triggered Inflammatory Status in Ovariectomy Mice journal October 2023
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Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss journal January 2018
Heterochronic faecal transplantation boosts gut germinal centres in aged mice journal June 2019
Barcoded overexpression screens in gut Bacteroidales identify genes with roles in carbon utilization and stress resistance journal August 2024
One-year supplementation with Lactobacillus reuteri ATCC PTA 6475 counteracts a degradation of gut microbiota in older women with low bone mineral density journal October 2022
Targeting the gut microbiota for cancer therapy journal October 2022
Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy journal June 2023
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Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer journal February 2023
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Lower endoscopic delivery of freeze-dried intestinal microbiota results in more rapid and efficient engraftment than oral administration journal February 2021
Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition journal September 2022
Bone loss is ameliorated by fecal microbiota transplantation through SCFA/GPR41/ IGF1 pathway in sickle cell disease mice journal November 2022
GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice journal January 2021
Microbiota from young mice counteracts selective age-associated behavioral deficits journal August 2021
Lactobacillus coryniformis subsp. torquens inhibits bone loss in obese mice via modification of the gut microbiota journal January 2023
Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways journal January 2024
Reversal of alopecia areata, osteoporosis follow treatment with activation of Tgr5 in mice journal July 2021
Altered microbiome in chronic kidney disease: systemic effects of gut-derived uremic toxins journal March 2018
Gut microbiome dysbiosis alleviates the progression of osteoarthritis in mice journal December 2020
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SER-109, an Oral Microbiome Therapy for Recurrent Clostridioides difficile Infection journal January 2022
Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate journal December 2008
Normal gut microbiota modulates brain development and behavior journal January 2011
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41) journal April 2011
Gut microbiota induce IGF-1 and promote bone formation and growth journal November 2016
Sphingosine 1-Phosphate (S1P) Receptors 1 and 2 Coordinately Induce Mesenchymal Cell Migration through S1P Activation of Complementary Kinase Pathways* journal February 2013
Absence of gut microbiota affects lipid metabolism in the prefrontal cortex of mice journal October 2019
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Depletion of gut microbiota induces skeletal muscle atrophy by FXR-FGF15/19 signalling journal January 2021
Gut microbiota-derived trimethylamine N-oxide is associated with the risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a systematic review and dose-response meta-analysis journal May 2023
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Circulating androgen regulation by androgen-catabolizing gut bacteria in male mouse gut journal February 2023
Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone mass journal July 2023
Nuanced contribution of gut microbiome in the early brain development of mice journal November 2023
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice journal November 2023
Diets intervene osteoporosis via gut-bone axis journal January 2024
Chemorepulsion by blood S1P regulates osteoclast precursor mobilization and bone remodeling in vivo journal December 2010
Alteration in the gut microbiome is associated with changes in bone metabolism after laparoscopic sleeve gastrectomy journal January 2024
Intestinal microbiota contributes to colonic epithelial changes in simulated microgravity mouse model journal August 2017
Intestinal microbiota contributes to altered glucose metabolism in simulated microgravity mouse model journal June 2019
Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway journal February 2022
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Fexaramine Inhibits Receptor Activator of Nuclear Factor-κB Ligand-induced Osteoclast Formation via Nuclear Factor of Activated T Cells Signaling Pathways journal January 2017
Effect of the gut microbiota on the expression of genes that are important for maintaining skin function: Analysis using aged mice journal December 2023
Proanthocyanidin‐Rich Grape Seed Extract Modulates Intestinal Microbiota in Ovariectomized Mice journal March 2018
Akkermansia muciniphila is a promising probiotic journal April 2019
Characteristics of various fibrolytic isozyme activities in the rumen microbial communities of Japanese Black and Holstein Friesian cattle under different conditions journal January 2021
Therapeutic potentials and modulatory mechanisms of fatty acids in bone journal December 2019
Gut microbiota modulates osteoclast glutathione synthesis and mitochondrial biogenesis in mice subjected to ovariectomy journal January 2022
Ursodeoxycholic acid decreases bilirubin‐induced osteoblast apoptosis journal November 2014
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Effect of intestinal microbiota on the induction of regulatory CD25+ CD4+ T cells journal May 2008
Lithocholic acid downregulates vitamin D effects in human osteoblasts journal December 2009
Association of a single nucleotide polymorphism in the constitutive androstane receptor gene with bone mineral density journal August 2009
Development and application of the human intestinal tract chip, a phylogenetic microarray: analysis of universally conserved phylotypes in the abundant microbiota of young and elderly adults journal July 2009
Diversity, metabolism and microbial ecology of butyrate-producing bacteria from the human large intestine journal May 2009
Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo‐controlled, double‐blind, clinical trial journal July 2018
Ursodeoxycholic acid increases differentiation and mineralization and neutralizes the damaging effects of bilirubin on osteoblastic cells journal April 2013
Bilirubin and bile acids in osteocytes and bone tissue. Potential role in the cholestatic‐induced osteoporosis journal October 2020
Intestinal microbiota influence the early postnatal development of the enteric nervous system journal October 2013
Gut dysbiosis contributes to amyloid pathology, associated with C/EBPβ/AEP signaling activation in Alzheimer’s disease mouse model journal July 2020
Glucocorticoid-induced loss of beneficial gut bacterial extracellular vesicles is associated with the pathogenesis of osteonecrosis journal April 2022
Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition journal February 2016
Commensal bacteria promote endocrine resistance in prostate cancer through androgen biosynthesis journal October 2021
Beyond the gut journal July 2022
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target journal August 2023
Neurogenesis and prolongevity signaling in young germ-free mice transplanted with the gut microbiota of old mice journal November 2019
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Fecal Microbiota Composition and Frailty journal October 2005
Meta-Analysis Reveals Compositional and Functional Microbial Changes Associated with Osteoporosis journal June 2023
Gut-Testis Axis: Microbiota Prime Metabolome To Increase Sperm Quality in Young Type 2 Diabetes journal October 2022
A metagenomic insight into our gut's microbiome journal April 2012
Mediterranean diet intervention alters the gut microbiome in older people reducing frailty and improving health status: the NU-AGE 1-year dietary intervention across five European countries journal February 2020
The Gut Microbiome and Inflammatory Bowel Diseases journal January 2022
High-intensity exercise training increases the diversity and metabolic capacity of the mouse distal gut microbiota during diet-induced obesity journal June 2016
Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells journal May 2016
Reconstitution of the host holobiont in germ-free born male rats acutely increases bone growth and affects marrow cellular content journal December 2021
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Gut Microbial Changes, Interactions, and Their Implications on Human Lifecycle: An Ageing Perspective journal January 2018
Butyrate Inhibits Osteoclast Activity In Vitro and Regulates Systemic Inflammation and Bone Healing in a Murine Osteotomy Model Compared to Antibiotic-Treated Mice journal December 2021
Disruption of the Gut Microbiota Confers Cisplatin Resistance in Epithelial Ovarian Cancer journal October 2022
Guggulsterone Inhibits Osteoclastogenesis Induced by Receptor Activator of Nuclear Factor-κB Ligand and by Tumor Cells by Suppressing Nuclear Factor-κB Activation journal January 2006
Osteoclast Precursors Display Dynamic Metabolic Shifts toward Accelerated Glucose Metabolism at an Early Stage of RANKL-Stimulated Osteoclast Differentiation journal January 2007
Gut Microbiota–Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice journal July 2020
Loss of Gut Microbiota Alters Immune System Composition and Cripples Postinfarction Cardiac Repair journal January 2019
Parathyroid hormone–dependent bone formation requires butyrate production by intestinal microbiota journal March 2020
Possible involvement of pregnane X receptor–enhanced CYP24 expression in drug-induced osteomalacia journal January 2005
Sex steroid deficiency–associated bone loss is microbiota dependent and prevented by probiotics journal April 2016
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways journal January 2023
Minocycline-induced disruption of the intestinal FXR/FGF15 axis impairs osteogenesis in mice journal January 2023
Propionic acid beneficially modifies osteoporosis biomarkers in patients with multiple sclerosis journal January 2022
Promising Aging in Community Models in the U.S.: Village, Naturally Occurring Retirement Community (NORC), Cohousing, and University-Based Retirement Community (UBRC) journal January 2021
Fecal microbiota transplantation from young mice rejuvenates aged hematopoietic stem cells by suppressing inflammation journal April 2023
Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells journal July 2020
The ketone body β-hydroxybutyrate alleviates CoCrMo alloy particles induced osteolysis by regulating NLRP3 inflammasome and osteoclast differentiation journal March 2022
Gold-nanosphere mitigates osteoporosis through regulating TMAO metabolism in a gut microbiota-dependent manner journal April 2023
A narrative review of the moderating effects and repercussion of exercise intervention on osteoporosis: ingenious involvement of gut microbiota and its metabolites journal October 2022
The combination of sport and sport-specific diet is associated with characteristics of gut microbiota: an observational study journal May 2019
Metabolomic profiles associated with bone mineral density in US Caucasian women journal August 2018
Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients journal October 2020
Accurate and sensitive detection of microbial eukaryotes from whole metagenome shotgun sequencing journal March 2021
Ageing and rejuvenation models reveal changes in key microbial communities associated with healthy ageing journal December 2021
Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain journal April 2022
Gut microbiota of the young ameliorates physical fitness of the aged in mice journal December 2022
The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis journal September 2023
Propionate and butyrate attenuate macrophage pyroptosis and osteoclastogenesis induced by CoCrMo alloy particles journal August 2022
Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML journal December 2023
The Route to Palatable Fecal Microbiota Transplantation journal April 2020
The Gut Microbiome Influences Host Endocrine Functions journal May 2019
Effects of Broad-Spectrum Antibiotic Treatment or Germ-Free Status on Endurance Performance and Exercise Adaptations in Mice journal September 2022
Relationship Between Rumen Microbial Composition and Fibrolytic Isozyme Activity During the Biodegradation of Rice Straw Powder Using Rumen Fluid journal January 2023
Incidence of and trends in hip fracture among adults in urban China: A nationwide retrospective cohort study journal August 2020
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians journal May 2010
Pregnane X Receptor Knockout Mice Display Aging-Dependent Wearing of Articular Cartilage journal March 2015
The short chain fatty acid receptor GPR43 regulates inflammatory signals in adipose tissue M2-type macrophages journal July 2017
Aged gut microbiota contribute to different changes in antioxidant defense in the heart and liver after transfer to germ-free mice journal August 2023
Efficacy of Fecal Microbiota Transplantation in Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis journal March 2019
Social Interaction Rescues Memory Deficit in an Animal Model of Alzheimer's Disease by Increasing BDNF-Dependent Hippocampal Neurogenesis journal December 2014
The gut microbiota modulates host amino acid and glutathione metabolism in mice journal October 2015
Microbiome dysbiosis by antibiotics protects cartilage degradation in OAOP mice journal January 2024
Pregnane X receptor knockout mice display osteopenia with reduced bone formation and enhanced bone resorption journal December 2010
Age-related shifts in gut microbiota contribute to cognitive decline in aged rats journal May 2020
Structural and functional changes of gut microbiota in ovariectomized rats and their correlations with altered bone mass journal June 2020
Gut microbial community and fecal metabolomic signatures in different types of osteoporosis animal models journal January 2024
The farnesoid X receptor negatively regulates osteoclastogenesis in bone remodeling and pathological bone loss journal August 2017
Adverse events in fecal microbiota transplantation: a systematic review and meta-analysis journal January 2022
Sphingosine 1-phosphate and osteoporosis: pathophysiology and therapeutic aspects—a narrative review journal April 2021
The role of gut microbiota metabolite trimethylamine N-oxide in functional impairment of bone marrow mesenchymal stem cells in osteoporosis disease journal August 2020
Bile Acid Derivatives: From Old Molecules to a New Potent Therapeutic Use: An Overview journal September 2018
Gut microbial-derived short-chain fatty acids and bone: a potential role in fracture healing journal April 2021
Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver journal January 2013
Presence or absence of microbiome modulates the response of mice organism to administered drug nabumetone journal January 2020
Glucocorticoid-induced osteoporosis is prevented by dietary prune in female mice journal February 2024
Age-Related Changes in the Gut Microbiota Modify Brain Lipid Composition journal January 2020
Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis journal December 2022
Impact of Sodium Butyrate Treatment in LPS-Stimulated Peripheral Blood Mononuclear Cells of Poorly Controlled Type 2 DM journal July 2021
The Association of Serum Total Bile Acids With Bone Mineral Density in Chinese Adults Aged 20–59: A Retrospective Cross-Sectional Study journal April 2022
The association between total bile acid and bone mineral density among patients with type 2 diabetes journal March 2023
Gut microbiota short-chain fatty acids and their impact on the host thyroid function and diseases journal June 2023
A two-cohort study on the association between the gut microbiota and bone density, microarchitecture, and strength journal September 2023
Lactobacillus plantarum attenuates glucocorticoid-induced osteoporosis by altering the composition of rat gut microbiota and serum metabolic profile journal January 2024
Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut journal June 2016
Comparative Evaluation of Microbiota Engraftment Following Fecal Microbiota Transfer in Mice Models: Age, Kinetic and Microbial Status Matter journal January 2019
Regular fecal microbiota transplantation to Senescence Accelerated Mouse-Prone 8 (SAMP8) mice delayed the aging of locomotor and exploration ability by rejuvenating the gut microbiota journal October 2022
Bile Acid-Mediated Sphingosine-1-Phosphate Receptor 2 Signaling Promotes Neuroinflammation during Hepatic Encephalopathy in Mice journal July 2017
Interplay Between Exercise and Gut Microbiome in the Context of Human Health and Performance journal June 2021
TMAO as a potential biomarker and therapeutic target for chronic kidney disease: A review journal August 2022
Bacteroides dorei BDX-01 alleviates DSS-induced experimental colitis in mice by regulating intestinal bile salt hydrolase activity and the FXR-NLRP3 signaling pathway journal May 2023
Lithocholic Acid Amides as Potent Vitamin D Receptor Agonists journal January 2022
An N-Cyanoamide Derivative of Lithocholic Acid Co-Operates with Lysophosphatidic Acid to Promote Human Osteoblast (MG63) Differentiation journal July 2023
Role of Endogenous Lipopolysaccharides in Neurological Disorders journal December 2022
The Human Gut Microbiota: A Key Mediator of Osteoporosis and Osteogenesis journal August 2021
The Microbiota–Gut–Brain Axis in Psychiatric Disorders
  • Góralczyk-Bińkowska, Aleksandra; Szmajda-Krygier, Dagmara; Kozłowska, Elżbieta
  • International Journal of Molecular Sciences, Vol. 23, Issue 19 https://doi.org/10.3390/ijms231911245
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Skin-to-Skin Contact: Crucial for Improving Behavior, Immunity, and Redox State after Short Cohabitation of Chronologically Old Mice and Prematurely Aging Mice with Adult Mice journal February 2023
The Ying and Yang of Sphingosine-1-Phosphate Signalling within the Bone journal April 2023
Efficacy and Safety of Fecal Microbiota Transplantation in Treatment of Clostridioides difficile Infection among Pediatric Patients: A Systematic Review and Meta-Analysis journal December 2022
Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts journal November 2019
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Effect of Curcumin on the Diversity of Gut Microbiota in Ovariectomized Rats journal October 2017
What we need to know about the germ-free animal models journal January 2024
Linking gut microbiome to bone mineral density: a shotgun metagenomic dataset from 361 elderly women journal January 2021
The molecular mechanism of propionate-regulating gluconeogenesis in bovine hepatocytes journal November 2023
Association between bile acid metabolism and bone mineral density in postmenopausal women journal January 2020
Fecal microbiota transplantation mitigates bone loss by improving gut microbiome composition and gut barrier function in aged rats journal October 2021