DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: The mycobiome as integral part of the gut microbiome: crucial role of symbiotic fungi in health and disease

Journal Article · · Gut Microbes
 [1];  [1];  [2];  [3];  [1];  [1]
  1. Department of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, P. R. China, Department of Gastroenterology, First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, P. R. China
  2. Department of Gastroenterology, Sichuan Fifth People’s Hospital, Chengdu, China
  3. Department of Clinical Medicine, Chengdu Medical College, Chengdu, Sichuan, P. R. China

Not Available

Sponsoring Organization:
USDOE EM Office of Technology Innovation and Development (EM-30)
OSTI ID:
2481635
Journal Information:
Gut Microbes, Journal Name: Gut Microbes Journal Issue: 1 Vol. 16; ISSN 1949-0976
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
United States
Language:
English

References (221)

The structure and synthesis of the fungal cell wall journal January 2006
Fonsecaea pedrosoi‐induced Th17‐cell differentiation in mice is fostered by Dectin‐2 and suppressed by Mincle recognition journal July 2015
Intestinal Fungal Dysbiosis and Systemic Immune Response to Fungi in Patients With Alcoholic Hepatitis journal August 2019
Fecal Fungi Dysbiosis in Nonalcoholic Fatty Liver Disease journal January 2021
Cheese yeasts journal January 2019
Pattern recognition receptors in antifungal immunity journal November 2014
Mucosa-associated microbiota signature in colorectal cancer journal June 2017
Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease journal February 2024
Colonic concentrations of hydrogen and methane following colonoscopic preparation with an oral lavage solution journal November 1990
Fungal β-Glucans and Mammalian Immunity journal September 2003
Roles of the gut virome and mycobiome in faecal microbiota transplantation journal May 2022
Prevalence of culturable airborne spores of selected allergenic and pathogenic fungi in outdoor air journal June 2008
Gut mycobiome: A promising target for colorectal cancer journal January 2021
Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression journal December 2016
Commensal bacteria and fungi differentially regulate tumor responses to radiation therapy journal September 2021
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer journal February 2022
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis journal July 2004
Pattern Recognition Receptors and Inflammation journal March 2010
Human Anti-fungal Th17 Immunity and Pathology Rely on Cross-Reactivity against Candida albicans journal March 2019
Human gut mycobiota tune immunity via CARD9-dependent induction of anti-fungal IgG antibodies journal February 2021
Mucosal fungi promote gut barrier function and social behavior via Type 17 immunity journal March 2022
A genomic compendium of cultivated human gut fungi characterizes the gut mycobiome and its relevance to common diseases journal June 2024
An Essential Role for the NLRP3 Inflammasome in Host Defense against the Human Fungal Pathogen Candida albicans journal May 2009
Identification of Distinct Ligands for the C-type Lectin Receptors Mincle and Dectin-2 in the Pathogenic Fungus Malassezia journal April 2013
Gut Dysbiosis Promotes M2 Macrophage Polarization and Allergic Airway Inflammation via Fungi-Induced PGE2 journal January 2014
Pathogenic NLRP3 Inflammasome Activity during Candida Infection Is Negatively Regulated by IL-22 via Activation of NLRC4 and IL-1Ra journal August 2015
Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease journal October 2015
Immunological Consequences of Intestinal Fungal Dysbiosis journal June 2016
Response to Fungal Dysbiosis by Gut-Resident CX3CR1+ Mononuclear Phagocytes Aggravates Allergic Airway Disease journal December 2018
Malassezia Is Associated with Crohn’s Disease and Exacerbates Colitis in Mouse Models journal March 2019
Commensal Candida albicans Positively Calibrates Systemic Th17 Immunological Responses journal March 2019
Fungal Trans-kingdom Dynamics Linked to Responsiveness to Fecal Microbiota Transplantation (FMT) Therapy in Ulcerative Colitis journal May 2020
Mechanisms of the inflammatory reaction implicated in alcoholic hepatitis: 2011 update journal June 2011
Correlation between gastrointestinal fungi and varying degrees of chronic hepatitis B virus infection journal August 2011
Fungal mitochondrial oxygen consumption induces the growth of strict anaerobic bacteria journal December 2017
Yeasts as probiotics: Mechanisms, outcomes, and future potential journal April 2020
C-Type Lectin Receptors Dectin-3 and Dectin-2 Form a Heterodimeric Pattern-Recognition Receptor for Host Defense against Fungal Infection journal August 2013
Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22 journal August 2013
Candida albicans Morphology and Dendritic Cell Subsets Determine T Helper Cell Differentiation journal February 2015
Immune Interactions with Pathogenic and Commensal Fungi: A Two-Way Street journal November 2015
Peripheral Lymphoid Volume Expansion and Maintenance Are Controlled by Gut Microbiota via RALDH+ Dendritic Cells journal February 2016
Homeostatic Immunity and the Microbiota journal April 2017
The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells journal September 2018
SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer journal September 2018
The Candida albicans exotoxin candidalysin promotes alcohol-associated liver disease journal March 2020
The fecal mycobiome in non-alcoholic fatty liver disease journal April 2022
Candidalysin: discovery and function in Candida albicans infections journal December 2019
Gut mycobiota under scrutiny: fungal symbionts or environmental transients? journal August 2019
Candida albicans biofilms: development, regulation, and molecular mechanisms journal May 2016
RETRACTED: The opportunistic human fungal pathogen Candida albicans promotes the growth and proliferation of commensal Escherichia coli through an iron-responsive pathway journal March 2018
A higher-level phylogenetic classification of the Fungi journal May 2007
Dietary modulation of immune function by β-glucans journal May 2008
Whole-grain wheat breakfast cereal has a prebiotic effect on the human gut microbiota: a double-blind, placebo-controlled, crossover study journal August 2007
Determination of thein vivoprebiotic potential of a maize-based whole grain breakfast cereal: a human feeding study journal May 2010
Fecal Microbiota Transplantation for Clostridium difficile Infection: Systematic Review and Meta-Analysis journal January 2013
Shotgun metaproteomics of the human distal gut microbiota journal October 2008
A human gut microbial gene catalogue established by metagenomic sequencing journal March 2010
Enterotypes of the human gut microbiome journal April 2011
Diet rapidly and reproducibly alters the human gut microbiome journal December 2013
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism journal January 2015
Dectin-1 is required for β-glucan recognition and control of fungal infection journal December 2006
Activation of HIF-1α and LL-37 by commensal bacteria inhibits Candida albicans colonization journal June 2015
CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands journal May 2016
JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression journal January 2017
Dectin 1 activation on macrophages by galectin 9 promotes pancreatic carcinoma and peritumoral immune tolerance journal April 2017
Fungal dysbiosis: immunity and interactions at mucosal barriers journal June 2017
The mycobiota: interactions between commensal fungi and the host immune system journal May 2014
Immune defence against Candida fungal infections journal September 2015
A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis journal August 2023
Gut fungal dysbiosis correlates with reduced efficacy of fecal microbiota transplantation in Clostridium difficile infection journal September 2018
The fungal peptide toxin Candidalysin activates the NLRP3 inflammasome and causes cytolysis in mononuclear phagocytes journal October 2018
Lactobacillus rhamnosus colonisation antagonizes Candida albicans by forcing metabolic adaptations that compromise pathogenicity journal June 2022
Comparison of Japanese and Indian intestinal microbiota shows diet-dependent interaction between bacteria and fungi journal December 2019
Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn’s disease journal November 2021
Mycobiota and diet-derived fungal xenosiderophores promote Salmonella gastrointestinal colonization journal November 2022
The gut mycobiota: insights into analysis, environmental interactions and role in gastrointestinal diseases journal March 2019
Recipient factors in faecal microbiota transplantation: one stool does not fit all journal April 2021
Microbiota succession throughout life from the cradle to the grave journal July 2022
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL journal October 2019
Galactosaminogalactan activates the inflammasome to provide host protection journal December 2020
Adaptive immunity induces mutualism between commensal eukaryotes journal July 2021
Revisiting the intrinsic mycobiome in pancreatic cancer journal August 2023
Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor journal June 2024
Multiple Approaches Detect the Presence of Fungi in Human Breastmilk Samples from Healthy Mothers journal October 2017
Transplantation of human microbiota into conventional mice durably reshapes the gut microbiota journal May 2018
The trans-kingdom battle between donor and recipient gut microbiome influences fecal microbiota transplantation outcome journal October 2020
The gut mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to diet journal March 2021
The gut commensal fungus, Candida parapsilosis, promotes high fat-diet induced obesity in mice journal October 2021
Obesity changes the human gut mycobiome journal October 2015
The structure of a β-(1→6)-d-glucan from yeast cell walls journal September 1973
Adherence of Escherichia coli serogroup 0 157 and the Salmonella Typhimurium mutant DT 104 to the surface of Saccharomyces boulardii journal August 1999
Glycannes pariétaux de levures et anticorps spécifiques journal May 2009
Interactions Between the Intestinal Microbiome and Liver Diseases journal May 2014
Roles for Intestinal Bacteria, Viruses, and Fungi in Pathogenesis of Inflammatory Bowel Diseases and Therapeutic Approaches journal January 2017
Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis journal July 2020
Population-Level Configurations of Gut Mycobiome Across 6 Ethnicities in Urban and Rural China journal January 2021
Altered Mycobiota Signatures and Enriched Pathogenic Aspergillus rambellii Are Associated With Colorectal Cancer Based on Multicohort Fecal Metagenomic Analyses journal October 2022
Human Dectin-1 Deficiency and Mucocutaneous Fungal Infections journal October 2009
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant journal November 2019
Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis journal November 2017
Microbial diversity in the deep sea and the underexplored "rare biosphere" journal July 2006
Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa journal August 2010
Nuclear ribosomal internal transcribed spacer (ITS) region as a universal DNA barcode marker for Fungi journal March 2012
The innate immune receptor Dectin-2 mediates the phagocytosis of cancer cells by Kupffer cells for the suppression of liver metastasis journal November 2016
C-type Lectin Receptor Dectin-3 Mediates Trehalose 6,6′-Dimycolate (TDM)-induced Mincle Expression through CARD9/Bcl10/MALT1-dependent Nuclear Factor (NF)-κB Activation journal October 2014
Toll-like Receptor (TLR) Signaling in Response toAspergillus fumigatus journal October 2002
Effect of various antibiotics on gastrointestinal colonization and dissemination byCandida albicans journal January 1985
Fungi and inflammatory bowel diseases: Alterations of composition and diversity journal January 2008
Impact ofSaccharomyces cerevisiaemetabolites produced during fermentation on bread quality parameters: A review journal June 2017
Cellular and molecular effects of yeast probiotics on cancer journal August 2016
Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE2 to alcoholic hepatic steatosis journal October 2020
Fungal signature differentiates alcohol-associated liver disease from nonalcoholic fatty liver disease journal February 2024
Fungi in the healthy human gastrointestinal tract journal September 2016
Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection journal August 2009
Candida albicansPhospholipomannan Is Sensed through Toll‐Like Receptors journal July 2003
Effect of diet on human fecal flora: comparison of Japanese and American diets journal December 1974
Time of Feeding Alters Obesity-Associated Parameters and Gut Bacterial Communities, but Not Fungal Populations, in C57BL/6 Male Mice journal February 2020
Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) journal March 2018
Fungal Dysbiosis in Mucosa-associated Microbiota of Crohn’s Disease Patients journal November 2015
The effect of antifungal resistance development on the virulence of Candida species journal March 2022
Toll-like Receptor 1 Polymorphisms Increase Susceptibility to Candidemia journal February 2012
Candida albicans Is Not Always the Preferential Yeast Colonizing Humans: A Study in Wayampi Amerindians journal July 2013
Aspergillus fumigatus Cell Wall α-(1,3)-Glucan Stimulates Regulatory T-Cell Polarization by Inducing PD-L1 Expression on Human Dendritic Cells journal September 2017
Fungi form interkingdom microbial communities in the primordial human gut that develop with gestational age journal August 2019
Malassezia restricta promotes alcohol-induced liver injury journal February 2023
Vertical and Horizontal Transmission of Candida albicans in Very Low Birth Weight Infants Using DNA Fingerprinting Techniques journal March 2008
Dysbiosis of Gut Fungal Microbiota is Associated With Mucosal Inflammation in Crohn’s Disease journal July 2014
Role of Probiotics in Crohn’s Disease and in Pouchitis journal November 2015
Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome journal June 2014
Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease journal August 2015
The Human Mycobiome journal November 2014
European Society of Clinical Microbiology and Infectious Diseases: Update of the Treatment Guidance Document for Clostridium difficile Infection journal March 2014
A Review on Kombucha Tea—Microbiology, Composition, Fermentation, Beneficial Effects, Toxicity, and Tea Fungus journal June 2014
Understanding Kombucha Tea Fermentation: A Review: Understanding Kombucha tea fermentation… journal March 2018
ITS1 versus ITS2 as DNA metabarcodes for fungi journal January 2013
ITS1: a DNA barcode better than ITS2 in eukaryotes? journal September 2014
Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases journal April 2015
Review article: yeast as probiotics –Saccharomyces boulardii journal July 2007
Transmission of the major skin microbiota, Malassezia, from mother to neonate journal April 2012
Candida and antibiotic-associated diarrhoea journal January 2005
The UNITE database for molecular identification of fungi - recent updates and future perspectives: Letters journal March 2010
New primers to amplify the fungal ITS2 region - evaluation by 454-sequencing of artificial and natural communities journal July 2012
The ITS region as a target for characterization of fungal communities using emerging sequencing technologies journal July 2009
Sequence-based methods for detecting and evaluating the human gut mycobiome journal February 2016
Gut mycobiome: The probable determinative role of fungi in IBD patients journal February 2021
Fungal community analysis by high-throughput sequencing of amplified markers - a user's guide journal March 2013
Diversity of the Human Intestinal Microbial Flora journal June 2005
A Catalog of Reference Genomes from the Human Microbiome journal May 2010
Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes journal September 2011
Interactions Between Commensal Fungi and the C-Type Lectin Receptor Dectin-1 Influence Colitis journal June 2012
Experimental evolution of a fungal pathogen into a gut symbiont journal November 2018
Oral epithelial cells orchestrate innate type 17 responses to Candida albicans through the virulence factor candidalysin journal November 2017
Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization journal June 2023
Environmental Study of Azole-Resistant Aspergillus fumigatus and Other Aspergilli in Austria, Denmark, and Spain journal November 2010
Prospective evaluation of effects of broad-spectrum antibiotics on gastrointestinal yeast colonization of humans journal January 1993
Abundant and Diverse Fungal Microbiota in the Murine Intestine journal January 2006
Dectin-2 Deficiency Promotes Th2 Response and Mucin Production in the Lungs after Pulmonary Infection with Cryptococcus neoformans journal February 2015
Dectin-1-Dependent Interleukin-22 Contributes to Early Innate Lung Defense against Aspergillus fumigatus journal January 2012
Saccharomyces boulardii Protease Inhibits the Effects of Clostridium difficile Toxins A and B in Human Colonic Mucosa journal January 1999
Saccharomyces boulardiiStimulates Intestinal Immunoglobulin A Immune Response toClostridium difficileToxin A in Mice journal April 2001
Role of Antibiotics and Fungal Microbiota in Driving Pulmonary Allergic Responses journal September 2004
Influence of Antibiotics or Certain Intestinal Bacteria on Orally Administered Candida albicans in Germ-Free and Conventional Mice journal December 1971
Bacteriome and Mycobiome Interactions Underscore Microbial Dysbiosis in Familial Crohn’s Disease journal September 2016
Manipulation of Host Diet To Reduce Gastrointestinal Colonization by the Opportunistic Pathogen Candida albicans journal February 2016
Investigating Colonization of the Healthy Adult Gastrointestinal Tract by Fungi journal April 2018
Interspecies Interactions between Clostridium difficile and Candida albicans journal December 2016
High-Fat Diet Changes Fungal Microbiomes and Interkingdom Relationships in the Murine Gut journal October 2017
Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years journal June 2010
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease journal January 2011
Fungal microbiota dysbiosis in IBD journal February 2016
Fungal dysbiosis in cirrhosis journal June 2017
Enteric fungal microbiota dysbiosis and ecological alterations in colorectal cancer journal November 2018
Cultivated human intestinal fungusCandida metapsilosisM2006B attenuates colitis by secreting acyclic sesquiterpenoids as FXR agonists journal February 2022
Mapping the human gut mycobiome in middle-aged and elderly adults: multiomics insights and implications for host metabolic health journal January 2022
The intestinal microbiota, gastrointestinal environment and colorectal cancer: a putative role for probiotics in prevention of colorectal cancer? journal September 2011
The Immunologic Role of Gut Microbiota in Patients with Chronic HBV Infection journal July 2018
Early Tumor–Immune Microenvironmental Remodeling and Response to First-Line Fluoropyrimidine and Platinum Chemotherapy in Advanced Gastric Cancer journal December 2021
Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors journal June 2006
Intestinal fungi contribute to development of alcoholic liver disease journal May 2017
Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders journal November 2011
Frailty in inflammatory bowel diseases: an emerging concept journal January 2021
The role of gut mycobiome in health and diseases journal January 2021
Prolonged fluconazole prophylaxis is associated with persistent protection against candidiasis-related death in allogeneic marrow transplant recipients: long-term follow-up of a randomized, placebo-controlled trial journal September 2000
ITS as an environmental DNA barcode for fungi: an in silico approach reveals potential PCR biases journal January 2010
Metagenomics - a guide from sampling to data analysis journal February 2012
The human mycobiome in health and disease journal January 2013
Long-term effects on luminal and mucosal microbiota and commonly acquired taxa in faecal microbiota transplantation for recurrent Clostridium difficile infection journal October 2016
Dysbiosis of the intestinal fungal microbiota increases lung resident group 2 innate lymphoid cells and is associated with enhanced asthma severity in mice and humans journal May 2023
Influence of diet on the gut microbiome and implications for human health journal April 2017
Identification of Schizosaccharomyces pombe in the guts of healthy individuals and patients with colorectal cancer: preliminary evidence from a gut microbiome secretome study journal July 2018
The gut mycobiome of the Human Microbiome Project healthy cohort journal November 2017
Antibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria journal September 2020
Lessons learned from the prenatal microbiome controversy journal January 2021
A Comprehensive, Automatically Updated Fungal ITS Sequence Dataset for Reference-Based Chimera Control in Environmental Sequencing Efforts journal January 2015
Taxonomic Reliability of DNA Sequences in Public Sequence Databases: A Fungal Perspective journal December 2006
Human Intestinal Lumen and Mucosa-Associated Microbiota in Patients with Colorectal Cancer journal June 2012
High-Coverage ITS Primers for the DNA-Based Identification of Ascomycetes and Basidiomycetes in Environmental Samples journal July 2012
Archaea and Fungi of the Human Gut Microbiome: Correlations with Diet and Bacterial Residents journal June 2013
Sequence Depth, Not PCR Replication, Improves Ecological Inference from Next Generation DNA Sequencing journal February 2014
Saccharomyces boulardii Modifies Salmonella Typhimurium Traffic and Host Immune Responses along the Intestinal Tract journal August 2014
A Novel Role for the NLRC4 Inflammasome in Mucosal Defenses against the Fungal Pathogen Candida albicans journal December 2011
Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut journal June 2016
Fungal‐induced glycolysis in macrophages promotes colon cancer by enhancing innate lymphoid cell secretion of IL‐22 journal February 2021
Comparison and Effects of Natural and Synthetic Glucose Tolerance Factor in Normal and Genetically Diabetic Mice journal January 1978
CandidaInfections: An Overview journal January 1987
Human intestinal microbiota: cross-talk with the host and its potential role in colorectal cancer journal September 2010
The influence of diet on gastrointestinal Candida spp. colonization and the susceptibility of Candida spp. to antifungal drugs journal January 2019
Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies journal September 2021
Age and Gender Affect the Composition of Fungal Population of the Human Gastrointestinal Tract journal August 2016
Preparing the Gut with Antibiotics Enhances Gut Microbiota Reprogramming Efficiency by Promoting Xenomicrobiota Colonization journal June 2017
The Fungal Frontier: A Comparative Analysis of Methods Used in the Study of the Human Gut Mycobiome journal July 2017
Longitudinal Survey of Fungi in the Human Gut: ITS Profiling, Phenotyping, and Colonization journal July 2019
Bacterial, fungal, and interkingdom microbiome features of exclusively breastfeeding dyads are associated with infant age, antibiotic exposure, and birth mode journal November 2022
Dynamic Changes of the Fungal Microbiome in Alcohol Use Disorder journal July 2021
Fermented Soy Products: Beneficial Potential in Neurodegenerative Diseases journal March 2021
The Role of Yeasts in Human Health: A Review journal March 2023
Fungal-Bacterial Interactions in Health and Disease journal May 2019
Cutting Edge: Candida albicans Hyphae Formation Triggers Activation of the Nlrp3 Inflammasome journal September 2009
Emergence of non-albicans candida species in neonatal candidemia journal January 2013
Aspergillus Associated with Meju, a Fermented Soybean Starting Material for Traditional Soy Sauce and Soybean Paste in Korea journal September 2015
Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses journal August 2014

Related Subjects