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Title: MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration

Journal Article · · Nucleic Acids Research
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  1. Wageningen University (Netherlands); et al.
  2. The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Building 220, Søltofts Plads, 2800 Kongens Lyngby,
  3. Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,
  4. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,
  5. School of Chemistry, Chemistry Building, University of Sydney , Eastern Ave, Camperdown NSW 2050 , Sydney , New South Wales ,
  6. Department of Chemistry, University of Konstanz, Universitätsstraße 10 , 78464  Konstanz ,
  7. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,; Myria Biosciences AG, Tech Park Basel , Hochbergstrasse 60C, 4057  Basel ,
  8. Department of Microbiology and Cell Science, University of Florida , 1355 Museum Drive, Gainesville , Florida , 32611 ,
  9. Ginkgo Bioworks , 27 Drydock Avenue, 8th Floor, Boston , MA  02210 ,
  10. Department of Microbiology and Cell Science, University of Florida , 1355 Museum Drive, Gainesville , Florida , 32611 ,; University of Florida Genetics Institute, University of Florida , 2033 Mowry Rd, Gainesville , FL 32611 ,
  11. School of Molecular Sciences, University of Western Australia , 35 Stirling Highway, Perth  6009 ,
  12. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,; Chair of Technical Biochemistry, Technical University of Dresden , Bergstraße 66, 01069  Dresden ,
  13. School of Chemical Sciences, University of Auckland , 23 Symonds St, Auckland  1010 ,
  14. Newcastle University, Biosciences Institute , Catherine Cookson Building, Newcastle upon Tyne , NE2 4HH ,
  15. Sutro Biopharma , 111 Oyster Point Blvd, South San Francisco , CA , 94080 ,
  16. Department of Chemistry, Faculty of Mathematics and Natural Sciences, IPB University , Gedung Kimia Wing 1 Lantai 3, Jalan Tanjung Kampus IPB Dramaga, Bogor, Jawa Barat 16680 ,
  17. Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,; LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,; Senckenberg Society for Nature Research , Senckenberganlage 25, 60325  Frankfurt am Main,
  18. Department of Chemistry, University of Warwick , Gibbet Hill Rd, Coventry , CV4 7AL ,; Warwick Integrative Synthetic Biology Centre (WISB), University of Warwick , Gibbet Hill Rd, Coventry , CV4 7AL ,
  19. Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo , 1-1-1, Yayoi, Bunkyo-ku, Tokyo , 113-8657 ,; Collaborative Research Institute for Innovative Microbiology, The University of Tokyo , 1-1-1, Yayoi, Bunkyo-ku, Tokyo , 113-8657 ,
  20. Translational Genome Mining for Natural Products, Interfaculty Institute of Microbiology and Infection Medicine Tübingen (IMIT), Interfaculty Institute for Biomedical Informatics (IBMI), University of Tübingen , Sand 14, 72076 Tübingen,
  21. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,; Saarland University, Campus E8.1 , 66123 Saarbrücken,; Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, 38124  Braunschweig ,
  22. Université Paris Cité - Inserm Unit 1284 , 75015  Paris ,; Translational Genome Mining for Natural Products, Generare Bioscience , 75011  Paris , Île-de-France,
  23. Sustainable Soils and Crops, Rothamsted Research , West Common, Harpenden , Hertfordshire , AL5 2JQ ,
  24. Computational Biology Lab, National Agri-Food and Biomanufacturing Institute (NABI) , Sector 81, S.A.S. Nagar , Mohali , Punjab  140306 ,; Regional Centre for Biotechnology, NCR Biotech Science Cluster , 3rd Milestone, Faridabad -Gurugram Expressway, Faridabad - 121001 Haryana (NCR Delhi ),
  25. Department of Chemistry and Biochemistry, University of Northern British Columbia, 3333 University Way , Prince George, BC , V2N 4Z9 ,
  26. Biochemistry and Metabolism, John Innes Centre , Norwich Research Park, Colney Lane, Norwich , NR4 7UH ,
  27. Latvian Institute of Organic Synthesis , Aizkraukles street 21, LV-1006  Riga ,
  28. Department of Pharmaceutical Sciences, Oregon State University , 1601 SW Jefferson Way, Corvallis , OR 97331-3507 ,
  29. Department of Ecology, Evolution and Marine Biology, University of California , 1169 Biological Sciences II, Santa Barbara , CA  93106 ,
  30. Department of Environmental Microbiology, Swiss Federal Institute of Aquatic Science and Technology , Ueberlandstrasse 133, 8600 Duebendorf,
  31. Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,; Plant-Microbe Interactions, Institute of Environmental Biology, Utrecht University , 3584 CH Utrecht ,; Faculty of Environment, Science and Economy, University of Exeter , TR10 9FE , Penryn , Cornwall ,
  32. Department of Pharmaceutical Sciences, University of Basel , Klingelbergstrasse 50, 4056  Basel ,
  33. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University , Minhang District, Shanghai  200240 ,
  34. Department of Biochemistry, University of Johannesburg, C2 Lab Building 224, Kingsway Campus, Cnr University & Kingsway Road , Auckland Park, Johannesburg  2006 ,; International Research and Development (R&D) Division , Omnia Nutriology, Omnia Holdings Ltd, Building H, Monte Circle, 178 Montecasino Blvd, Fourways , Sandton , 2055 ,
  35. Department of Marine Resource Science, Faculty of Agriculture and Marine Science, Kochi University , 200 Otsu , Monobe, Nankoku -shi, Kochi , 783-8502 ,; Marine Core Research Institute, Kochi University , 200 Otsu , Monobe, Nankoku -shi, Kochi , 783-8502 ,
  36. Department of Pharmacology and Toxicology, University of Utah , 30 S 2000 E, Salt Lake City, Utah , 84112 ,
  37. Industrial Genomics Laboratory , Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501 sur , Nuevo Leon, 64700 ,; Department of Chemistry, Purdue University , 610 Purdue Mall, West Lafayette , IN, 47907 ,
  38. Department of Organic Chemistry, Institute of Chemistry, University of Campinas (UNICAMP) , Rua Monteiro Lobato 270, Campinas, São Paulo , 13.083-862,
  39. Department of Applied Sciences, University of Technology , Al-Sina’a St., 10066 , Baghdad ,
  40. School of Life Sciences, University of Warwick , Gibbet Hill Road, Coventry , CV4 7AL ,
  41. Department of Food and Animal Sciences, College of Agriculture, Tennessee State University , Nashville , TN 37209 ,
  42. Department of Biosciences, Swansea University , Singleton Park, Swansea , SA2 8PP ,
  43. Escuela Nacional de Estudios Superiores Unidad Leon, Universidad Nacional Autonoma de Mexico , Blv. UNAM # 2011 , Predio El Saucillo y, Comunidad de los Tepetates, El Potrero, 37684 León de los Aldama, Gto.,
  44. School of Molecular Sciences, University of Western Australia , 35 Stirling Highway, Perth  6009 ,; Department of Botany and Microbiology, College of Science, King Saud University , P.O. Box 2455 , Riyadh , 11451 ,
  45. Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,; Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,
  46. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla , CA  92093-0212 ,
  47. Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional , Km 9.6 Libramiento Norte Carretera Irapuato-León, 36824 , Irapuato ,
  48. Department of Chemistry, University of Manitoba , 66 Chancellors Circle, Winnipeg , MB R3T 2N2 ,
  49. Department of Chemistry, University of Illinois Urbana-Champaign , 600 S. Matthews Ave, Urbana , IL  61801 ,; Carl R. Woese Institute for Genomic Biology, University of Illinois Urbana-Champaign , 1206 W. Gregory Drive, Urbana , IL  61801 ,
  50. Institute of Pharmaceutical Biology, University of Bonn , Nussallee 6, 53115  Bonn ,
  51. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,; Saarland University, Campus E8.1 , 66123 Saarbrücken,
  52. Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen , Auf der Morgenstelle 28, 72076 , Tübingen,
  53. Institute of Pharmaceutical Biology and Biotechnology, University of Marburg , Robert-Koch-Str. 4, 35037  Marburg ,
  54. Departamento de Microbiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Av. Universidad 2001 , Chamilpa, 62210  Cuernavaca , Morelos ,; Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos , Av. Germán Amézaga S/N, Ciudad Universitaria, UNMSM, Lima  15081 ,
  55. Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,; LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,
  56. Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro , Avenida Athos da Silveira Ramos, no 149, Rio de Janeiro, 21941 -909,
  57. Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,; Institute for Molecular Bio Science, Goethe University Frankfurt , Max-von-Laue Strasse 9, 60438  Frankfurt am Main,; LOEWE Center for Translational Biodiversity Genomics (TBG) , Senckenberganlage 25, 60325  Frankfurt am Main,
  58. Instituto de Pesquisas de Produtos Naturais Walter Mors, Universidade Federal do Rio de Janeiro , CCS - Av. Carlos Chagas Filho, 373 - Bloco H - Cidade Universitária, Rio de Janeiro - RJ, 21941 -599,
  59. Department of Biology, Humboldt University Berlin , Invaliden-Str. 42, 10115  Berlin ,; Institute of Marine Biotechnology (IMaB), University of Greifswald ,Walter-Rathenau-Str. 49A, 17489  Greifswald ,
  60. Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,; Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” (IHSM-UMA-CSIC), Campus Universitario de Teatinos , 29010 , Málaga,; Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW) , Droevendaalsesteeg 10 6708 PB Wageningen ,
  61. School of Cellular and Molecular Biology, Faculty of Biological Sciences, University of Leeds , 6 Clarendon Way, Woodhouse, Leeds , LS2 3AA ,
  62. CICA – Centro Interdisciplinar de Química e Bioloxía, Universidade da Coruña, As Carballeiras, s/n, Campus de Elviña , 15071 A Coruña,
  63. Centre of Biological Engineering, University of Minho , 4710-057 , Braga ,
  64. Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,; Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” (IHSM-UMA-CSIC), Campus Universitario de Teatinos , 29010 , Málaga,; Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga , 29010 Málaga,
  65. Interdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR), University of Porto , 4450-208  Matosinhos ,
  66. Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, 38124  Braunschweig ,; Institute of Microbiology, Technische Universität Braunschweig , Spielmannstraße 7, 38106  Braunschweig ,
  67. Microbial Interactions in Plant Ecosystems, IMIT/ZMBP, Eberhard Karls University of Tübingen , 72076 Tübingen,
  68. College of Pharmacy, Yeungnam University , 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541 ,; Research Institute of Cell Culture, Yeungnam University , 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541 ,
  69. College of Pharmacy and Drug Information Research Institute, Sookmyung Women's University , 100 Cheongpa-ro 47 gil, Seoul  04310 ,
  70. Fungal Natural Products, Westerdijk Fungal Biodiversity Institute , Uppsalalaan 8, 3584CT  Utrecht ,
  71. Manchester Institute of Biotechnology, Department of Chemistry, School of Natural Sciences, Faculty of Science and Engineering, University of Manchester , 131 Princess Street, Manchester  M1 7DN ,
  72. Innovative Genomics Institute, University of California Berkeley , 2151 Berkeley Way, Berkeley , CA  94720 ,; Department of Earth and Planetary Science, University of California , 307 McCone Hall Berkeley, CA  94720-4767 ,
  73. Université Paris-Saclay , INRAE, UR BIOGER, 22 place de l’Agronomie, 91120  Palaiseau ,
  74. IOCB Prague, Czech Academy of Science , Flemingovo náměstí 542/2, 160 00  Praha 6,
  75. Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga , 29010 Málaga,
  76. Department of Ecosustainable Marine Biotechnology , Stazione Zoologica Anton Dohrn, Giardini del Molosiglio, Via A.F. Acton 55, 80133  Naples ,
  77. Department of Bioscience Engineering, Research Group Laboratory of Applied Microbiology and Biotechnology, University of Antwerp , Groenenborgerlaan 171, 2020 Antwerp,
  78. US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory , 1 Cyclotron Road, Berkeley , CA  94720 ,
  79. Biochemistry of Microorganisms, Faculty of Life Sciences: Food, Nutrition, and Health, University of Bayreuth , Fritz-Hornschuch-Straße 13, 95326  Kulmbach ,
  80. SIB Swiss Institute of Bioinformatics , Centre Medical Universitaire, 1 rue Michel Servet, 1211  Geneva 4,
  81. Department of Microbiology, University of Helsinki , Viikinkaari 9, 00017 , Helsinki ,
  82. Research Center for Food Technology and Processing , Research Organization of Agriculture and Food, National Research and Innovation Agency (BRIN), Jl. Jogja - Wonosari Km 31.5, DI. Yogyakarta  55861 ,; Microbial Metabolites for Food Research Group, National Research and Innovation Agency (BRIN) , Jl. Jogja - Wonosari Km 31.5, Gunungkidul, DI. Yogyakarta  55861 ,
  83. Microbial and Environmental Genomics Group, J. Craig Venter Institute , 4120 Capricorn Lane, La Jolla , CA 92037,
  84. NAICONS Srl , viale Ortles 22/4, 20139  Milan ,; Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Biosciences complex – Pavilion 02, Sciences and Technology Campus 11/A , 43124  Parma ,
  85. Institute for Organic Chemistry, Leibniz Universität Hannover , Schneiderberg 38, 30167  Hannover ,
  86. VIB-KU Leuven Center for Microbiology, Flanders Institute for Biotechnology , Kasteelpark Arenberg 31, 3001  Leuven ,; Department of Biology, Laboratory for Biomolecular Discovery & Engineering , KU Leuven , Kasteelpark Arenberg 31, 3001  Leuven ,; Department of Biosystems , Biosensors Group, KU Leuven , Willem de Croylaan 42, box 2428 , 3001  Leuven ,
  87. Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH , Inhoffenstraße 7B, 38124 Braunschweig ,
  88. Industrial Genomics Laboratory , Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501 sur , Nuevo Leon, 64700 ,
  89. Centro de Ciencias Matemáticas National Autonomous University of Mexico (UNAM) Antigua Carretera a Pátzcuaro # 8701 , Sin Nombre, Residencial San José de la Huerta, 58089  Morelia , Mich
  90. Biosphere Sciences and Engineering Division, Carnegie Institution for Science , 3520 San Martin Dr, Baltimore , MD, 21218 ,
  91. Program in Chemical Biology, University of Michigan , 210 Washtenaw Avenue, Ann Arbor , MI ,; Life Sciences Institute, University of Michigan , 210 Washtenaw Avenue, Ann Arbor , Michigan ,
  92. Department of Chemical and Pharmaceutical Biology, University of Groningen , Antonius Deusinglaan 1, 9713AV  Groningen ,
  93. Department of Chemistry, The University of Hong Kong , Pokfulam Road, Hong Kong ,
  94. Department of Biomolecular Chemistry, Leibniz Institute for Natural Product Research and Infection Biology (HKI) , Adolf-Reichwein-Straße 23, 07745  Jena ,
  95. Institute of Infectious Disease Research, McMaster University , 1280 Main Street West, Hamilton , Ontario , L8S4L8,; Department of Biology, McMaster University , 1280 Main Street West, Hamilton , Ontario , L8S4K1 ,
  96. Department of Biotechnology and Nanomedicine , SINTEF Industry , P.O.Box 4760 Torgard, N- 7465 Trondheim,
  97. Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,; Microbiology Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,
  98. Corteva Agriscience , 9330 Zionsville Road, Indianapolis , Indiana  46268 ,
  99. Natural Products Research Institute, College of Pharmacy, Seoul National University , 101 Daehak-ro, Jongro-gu, Seoul 110-744,
  100. Molecular Targets Program, Center for Cancer Research, National Cancer Institute , Frederick , Maryland  21702-1201 ,
  101. Production Host Engineering Team, VTT Technical Research Centre of Finland Ltd , Maarintie 3, 02150  Espoo ,
  102. NAICONS Srl , viale Ortles 22/4, 20139  Milan ,
  103. Department of Chemistry and Biochemistry, Laboratories of Molecular Recognition, Florida State University , 95 Chieftan Way, Tallahassee , FL 32306 ,
  104. Department of Applied Biology, College of Agriculture and Life Sciences, Chonnam National University , 77 Yongbong-ro, Buk-gu, Gwangju , 61186 ,
  105. Research Institute of Cell Culture, Yeungnam University , 280 Daehak-ro Gyeongsan-Si, Gyeongsangbuk-do 38541 ,; Department of Pharmacology, College of Medicine, Dongguk University , Dongdae-ro 123, Gyeongju-si, Gyeongsangbuk-do 38066 ,
  106. College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University-Seoul , Dongguk-ro 32, Goyang  10326 ,
  107. Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST) , Daejeon  34141 ,
  108. Department of Paleobiotechnology, Leibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute , Beutenbergstr. 11a, 07745  Jena ,
  109. Chair of Technical Biochemistry, Technical University of Dresden , Bergstraße 66, 01069  Dresden ,
  110. Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,; DTU Bioengineering, Technical University of Denmark , 2800 Kgs. Lyngby ,
  111. Department of Chemical and Biomolecular Engineering, University of Delaware , Newark, DE,
  112. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,; Saarland University, Campus E8.1 , 66123 Saarbrücken,; German Centre for Infection Research (DZIF) , Inhoffenstr. 7, 38124  Hannover -Braunschweig,
  113. Center of Infectious Diseases, Leiden University Medical Center , Albinusdreef 2, 2333 ZA Leiden ,
  114. Bioinformatics department , Endogenomiks, El Marqués, Querétaro,
  115. Université Paris Cité - Inserm Unit 1284 , 75015  Paris ,
  116. Department of Bioscience Engineering, Research Group Laboratory of Applied Microbiology and Biotechnology, University of Antwerp , Groenenborgerlaan 171, 2020 Antwerp,; U-MaMi Centre of Excellence , Middelheimlaan 1, 2020 Antwerp,
  117. Industrial Genomics Laboratory , Centro de Biotecnología FEMSA, Escuela de Ingeniería y Ciencias, Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501 sur , Nuevo Leon, 64700 ,; Integrative Biology Research Unit, The Institute for Obesity Research , Tecnológico de Monterrey, Av. Eugenio Garza Sada 2501  sur , Nuevo Leon, 64700 .
  118. School of Innovation and Sustainability, De La Salle University , Laguna Boulevard, LTI Spine Road, Brgys. Biñan and Malamig, 4024 Biñan City, Laguna ,; Department of Chemistry, De La Salle University , 2401 Taft Avenue, 0922  Manila ,
  119. Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,
  120. University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences , Glasgow , G4 0RE 
  121. Department of Biotechnology and Biomedicine, Technical University of Denmark , Søltofts Plads, Building 221, 2800 Kgs. Lyngby ,
  122. Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures GmbH , Inhoffenstraße 7B, 38124 Braunschweig ,; Technical University of Braunschweig, Institute of Microbiology , Rebenring 56, 38106  Braunschweig ,
  123. Ferrier Research Institute, Victoria University of Wellington , Kelburn Parade, Wellington  6012 ,; Maurice Wilkins Centre for Molecular Biodiscovery, Victoria University of Wellington , Kelburn Parade, Wellington  6012 ,
  124. Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,; Theoretical Biology and Bioinformatics, Department of Biology, Faculty of Science, Utrecht University , 3584 CH Utrecht ,
  125. Department of Biological and Chemical Engineering, Aarhus University , Gustav Wieds Vej 10, 8000  Aarhus C,
  126. Department of Life Technologies, University of Turku , Tykistökatu 6, FIN-20520  Turku ,
  127. Department of Chemistry, University of Illinois Urbana-Champaign , 600 S. Matthews Ave, Urbana , IL  61801 ,
  128. Institute of Pharmacy, Freie Universität Berlin , Königin-Luise-Str. 2+4, 14195  Berlin ,
  129. Department of Crop Protection, Instituto de Hortofruticultura Subtropical y Mediterránea “La Mayora” (IHSM-UMA-CSIC), Campus Universitario de Teatinos , 29010 , Málaga,; Department of Microbiology, Faculty of Science, Campus Universitario de Teatinos s/n, University of Málaga , 29010 Málaga,
  130. Department of Genetics and Biotechnology, Ivan Franko National University of Lviv , Hrushevskoho st 4, Lviv 79005 ,; German-Ukrainian Core of Excellence in Natural Products Research , Zelena str. 20, Lviv 79005 ,
  131. US Department of Energy Joint Genome Institute, Lawrence Berkeley National Laboratory , 1 Cyclotron Road, Berkeley , CA  94720 ,; Environmental Genomics and Systems Biology Division, Lawrence Berkeley National Laboratory , 1 Cyclotron Road, Berkeley , CA  94720 ,
  132. Computational Biology Lab, National Agri-Food and Biomanufacturing Institute (NABI) , Sector 81, S.A.S. Nagar , Mohali , Punjab  140306 ,
  133. Centro de Investigaciones en Productos Naturales (CIPRONA), Universidad de Costa Rica , San José, 11501-2060 ,; Centro Nacional de Innovaciones Biotecnológicas (CENIBiot) , CeNAT-CONARE, 1174-1200 , San José,; Instituto de Investigaciones Farmacéuticas (INIFAR), Facultad de Farmacia, Universidad de Costa Rica , San José, 11501-2060 ,
  134. Department of Microbiology and Immunology at the Doherty Institute, University of Melbourne , Grattan Street, Parkville Victoria, Victoria  3000 ,
  135. Institute of Microbiology, Eidgenössische Technische Hochschule (ETH) Zurich , Vladimir-Prelog Weg 4, 8093  Zurich ,
  136. Department of Plant Pathology, University of California Davis , One Shields Avenue, Davis , CA  95616-8751 ,
  137. Department of Chemistry, Aarhus University , Langelandsgade 140, DK- 8000 , Aarhus C,
  138. The Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark , Building 220, Søltofts Plads, 2800 Kongens Lyngby,; Department of Biotechnology and Biomedicine, Technical University of Denmark , Søltofts Plads, Building 221, 2800 Kgs. Lyngby ,
  139. Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,; Unidad de Genómica Avanzada, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional , Km 9.6 Libramiento Norte Carretera Irapuato-León, 36824 , Irapuato ,
  140. Institute for Molecular Systems Biology , ETH Zürich , Otto-Stern-Weg 3, 8093  Zürich ,
  141. Laboratorio de Microbiología Molecular y Biotecnología Ambiental, Centro de Biotecnología DAL, Universidad Técnica Federico Santa María , Avenida España 1680 , 2390123, Valparaíso,
  142. Department of Chemistry and BioDiscovery Institute, University of North Texas , 1155  Union Circle, Denton , Texas  76203 ,
  143. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Campus E8.1 , 66123 Saarbrücken,; German Centre for Infection Research (DZIF) , Inhoffenstr. 7, 38124  Hannover -Braunschweig,; Helmholtz Centre for Infection Research (HZI) , Inhoffenstr. 7, 38124  Braunschweig ,
  144. Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen , Auf der Morgenstelle 28, 72076 , Tübingen,; Masaryk University, Faculty of Science , RECETOX, Kamenice 753/5, 625 00  Brno ,
  145. School of Biological Sciences, University of Bristol , Life Sciences Building, 24 Tyndall Avenue, Bristol , BS8 1TQ ,; School of Chemistry, University of Bristol , Cantock's Close, Bristol,  BS8 1TS ,
  146. Fungal Natural Products, Westerdijk Fungal Biodiversity Institute , Uppsalalaan 8, 3584CT  Utrecht ,; Institute of Biotechnology, Helsinki Institute of Life Science, University of Helsinki , Viikinkaari 5, 00790 , Helsinki ,
  147. Department of Chemistry, University of Zurich ,Winterthurerstrasse 190, 8057  Zurich ,
  148. Department of Biology, University of Padova , Via U. Bassi, 58/B, 35121  Padova ,; Botanical Garden, University of Padova , Via Orto Botanico 15, 35123  Padova ,
  149. Department of Biological Sciences and Evolutionary Studies Initiative, Vanderbilt University , 465 21st Ave S, Nashville , TN 37232 ,
  150. Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Microbial Bioactive Compounds, University of Tübingen , Auf der Morgenstelle 28, 72076 , Tübingen,; German Centre for Infection Research (DZIF) , Partner Site Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen,
  151. DE SANGOSSE , Bonnel, 47480 , Pont-Du-Casse,; Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, Université Toulouse III , Toulouse INP, 24 Chemin de Borde Rouge, Auzeville, 31320 , Auzeville-Tolosane,
  152. Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,; Department of Biology, Laboratory for Biomolecular Discovery & Engineering , KU Leuven , Kasteelpark Arenberg 31, 3001  Leuven ,
  153. Institute for Microbial Biotechnology and Metagenomics, Department of Biotechnology, University of the Western Cape , Robert Sobukwe Rd, Bellville, 7535 ,
  154. Department of Molecular Microbiology , John Innes Centre, Norwich Research Park, Norwich , NR4 7UH , United Kingdome, Norwich ,
  155. Institute of Biology, Leiden University , Sylviusweg 72, 2333BE  Leiden ,; Department of Microbial Ecology, Netherlands Institute of Ecology (NIOO-KNAW) , Droevendaalsesteeg 10 6708 PB Wageningen ,
  156. VIB-KU Leuven Center for Microbiology, Flanders Institute for Biotechnology , Kasteelpark Arenberg 31, 3001  Leuven ,; The Rosalind Franklin Institute, R113 Rutherford Appleton Laboratory, Harwell Science and Innovation Campus , Didcot , Oxfordshire, OX11 0QX ,
  157. School of Biological Sciences, University of Bristol , Life Sciences Building, 24 Tyndall Avenue, Bristol , BS8 1TQ ,; School of Applied Sciences, University of the West of England, Frenchay Campus , Coldharbour Lane, Bristol , BS16 1QY ,
  158. Department of Chemistry and Biomolecular Sciences, University of Ottawa , 10 Marie Curie Private, Ottawa , Ontario , K1N 6N5 ,
  159. Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California San Diego , 9500 Gilman Drive, La Jolla , CA  92093-0212 ,; Microbial and Environmental Genomics Group, J. Craig Venter Institute , 4120 Capricorn Lane, La Jolla , CA 92037,
  160. Natural Products Discovery Center, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida , Jupiter , Florida  33458 ,
  161. Synthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea University , Anam-ro 145, Seongbuk-gu, Seoul  02841 ,
  162. Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology , 1088 Xueyuan Avenue, Shenzhen  518055 ,
  163. College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology , Chaowang Raod 18, Hangzhou  310014 ,
  164. Institute of Chemical, Environmental and Bioscience Engineering , TU Wien , Gumpendorfer Strasse 1a, 1060  Vienna ,
  165. Bioinformatics Group, Wageningen University & Research , Droevendaalsesteeg 1, 6708 PB Wageningen ,; Department of Biochemistry, University of Johannesburg, C2 Lab Building 224, Kingsway Campus, Cnr University & Kingsway Road , Auckland Park, Johannesburg  2006 ,
  166. Department of Chemistry, Simon Fraser University, 8888 University Drive , Burnaby, British Columbia, V5A 1S6 ,
+ Show Author Affiliations

Specialized or secondary metabolites are small molecules of biological origin, often showing potent biological activities with applications in agriculture, engineering and medicine. Usually, the biosynthesis of these natural products is governed by sets of co-regulated and physically clustered genes known as biosynthetic gene clusters (BGCs). To share information about BGCs in a standardized and machine-readable way, the Minimum Information about a Biosynthetic Gene cluster (MIBiG) data standard and repository was initiated in 2015. Since its conception, MIBiG has been regularly updated to expand data coverage and remain up to date with innovations in natural product research. Here, we describe MIBiG version 4.0, an extensive update to the data repository and the underlying data standard. In a massive community annotation effort, 267 contributors performed 8304 edits, creating 557 new entries and modifying 590 existing entries, resulting in a new total of 3059 curated entries in MIBiG. Particular attention was paid to ensuring high data quality, with automated data validation using a newly developed custom submission portal prototype, paired with a novel peer-reviewing model. MIBiG 4.0 also takes steps towards a rolling release model and a broader involvement of the scientific community. MIBiG 4.0 is accessible online at https://mibig.secondarymetabolites.org/.

Research Organization:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Organization:
USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science (BSS)
Grant/Contract Number:
AC02-05CH11231
OSTI ID:
2481018
Journal Information:
Nucleic Acids Research, Journal Name: Nucleic Acids Research Journal Issue: D1 Vol. 53; ISSN 0305-1048
Publisher:
Oxford University PressCopyright Statement
Country of Publication:
United States
Language:
English

References (14)

Deep Learning to Predict the Biosynthetic Gene Clusters in Bacterial Genomes journal August 2022
CyanoMetDB, a comprehensive public database of secondary metabolites from cyanobacteria journal May 2021
Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019 journal March 2020
Minimum Information about a Biosynthetic Gene cluster journal August 2015
Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences journal November 2020
Mining genomes to illuminate the specialized chemistry of life journal June 2021
Ribosome-independent peptide biosynthesis: the challenge of a unifying nomenclature journal January 2022
The evolution of gene collectives: How natural selection drives chemical innovation journal January 2008
DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products journal December 2019
MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters journal November 2022
antiSMASH 7.0: new and improved predictions for detection, regulation, chemical structures and visualisation journal May 2023
BAGEL4: a user-friendly web server to thoroughly mine RiPPs and bacteriocins journal May 2018
A deep learning genome-mining strategy for biosynthetic gene cluster prediction journal August 2019
DECIMER: towards deep learning for chemical image recognition journal October 2020

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