DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens

Journal Article · · Communications Biology
ORCiD logo; ORCiD logo; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ORCiD logo; ; more »; ORCiD logo; ORCiD logo; ; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo; ; ; ORCiD logo; ORCiD logo; ORCiD logo; ORCiD logo « less

Not Available

Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-05CH11231; AC02-06CH11357
OSTI ID:
2479925
Journal Information:
Communications Biology, Journal Name: Communications Biology Journal Issue: 1 Vol. 7; ISSN 2399-3642
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (85)

PCNA binding through a conserved motif journal March 1998
Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features journal December 1983
UCSF Chimera?A visualization system for exploratory research and analysis journal January 2004
The PCNA interaction motifs revisited: thinking outside the PIP-box journal May 2019
The bacterial DNA sliding clamp, β-clamp: structure, interactions, dynamics and drug discovery journal May 2024
Three-dimensional structure of the β subunit of E. coli DNA polymerase III holoenzyme: A sliding DNA clamp journal May 1992
Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA journal December 1994
ATP activation of DNA polymerase III holoenzyme of Escherichia coli. I. ATP-dependent formation of an initiation complex with a primed template. journal October 1982
ATP activation of DNA polymerase III holoenzyme from Escherichia coli. II. Initiation complex: stoichiometry and reactivity. journal October 1982
Mechanism of the sliding beta-clamp of DNA polymerase III holoenzyme journal June 1991
Processive DNA synthesis by DNA polymerase II mediated by DNA polymerase III accessory proteins. journal June 1992
Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli. journal January 1981
Purification and characterization of the beta subunit of the DNA polymerase III holoenzyme of Escherichia coli. journal November 1980
Escherichia coli DNA polymerase II is stimulated by DNA polymerase III holoenzyme auxiliary subunits journal March 1991
Structure of the C-Terminal Region of p21WAF1/CIP1 Complexed with Human PCNA journal October 1996
Mechanism of Processivity Clamp Opening by the Delta Subunit Wrench of the Clamp Loader Complex of E. coli DNA Polymerase III journal August 2001
Clamp loaders and sliding clamps journal April 2002
The high resolution structure of tyrocidine A reveals an amphipathic dimer journal May 2014
Structure of a Sliding Clamp on DNA journal January 2008
New Griselimycins for Treatment of Tuberculosis journal August 2015
The endonuclease domain of MutL interacts with the β sliding clamp journal January 2011
Structural and Biochemical Analysis of Sliding Clamp/Ligand Interactions Suggest a Competition Between Replicative and Translesion DNA Polymerases journal January 2004
Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens journal December 2018
Protein production by auto-induction in high-density shaking cultures journal May 2005
Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp journal November 2021
Bacterial Sliding Clamp Inhibitors that Mimic the Sequential Binding Mechanism of Endogenous Linear Motifs journal May 2015
Inhibition of Protein Interactions with the β 2 Sliding Clamp of Escherichia coli DNA Polymerase III by Peptides from β 2 -Binding Proteins journal April 2004
A Quantitative Study of the in Vitro Binding of the C-Terminal Domain of p21 to PCNA:  Affinity, Stoichiometry, and Thermodynamics journal May 2000
Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp journal January 2024
High-Throughput Synthesis and Screening of Cyclic Peptide Antibiotics journal June 2007
Structure-Based Design of Short Peptide Ligands Binding onto the E. coli Processivity Ring journal June 2011
Binding Inhibitors of the Bacterial Sliding Clamp by Design journal June 2011
Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp journal October 2013
Biomimetic synthesis and optimization of cyclic peptide antibiotics journal August 2002
Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7 journal June 2008
Single-molecule studies of fork dynamics in Escherichia coli DNA replication journal January 2008
Elucidation of unusual biosynthesis and DnaN-targeting mode of action of potent anti-tuberculosis antibiotics Mycoplanecins journal January 2024
Biosynthesis of methyl-proline containing griselimycins, natural products with anti-tuberculosis activity journal January 2017
Clamp loading, unloading and intrinsic stability of the PCNA, β and gp45 sliding clamps of human, E. coli and T4 replicases journal January 1996
DNA repair in Mycobacterium tuberculosis. What have we learnt from the genome sequence? journal September 1998
Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp journal August 2008
Interaction of the   sliding clamp with MutS, ligase, and DNA polymerase I journal July 2001
A universal protein-protein interaction motif in the eubacterial DNA replication and repair systems journal September 2001
UmuD'2C is an error-prone DNA polymerase, Escherichia coli pol V journal August 1999
The Escherichia coli SOS mutagenesis proteins UmuD and UmuD' interact physically with the replicative DNA polymerase journal October 1999
ATP Binding to the Escherichia coli Clamp Loader Powers Opening of the Ring-shaped Clamp of DNA Polymerase III Holoenzyme journal September 1998
Protein Associations in DnaA-ATP Hydrolysis Mediated by the Hda-Replicase Clamp Complex journal February 2005
The β Sliding Clamp Binds to Multiple Sites within MutL and MutS journal May 2006
The Production of Bactericidal Substances by Aerobic Sporulating Bacilli journal May 1941
The processivity factor β controls DNA polymerase IV traffic during spontaneous mutagenesis and translesion synthesis in vivo journal January 2002
Structural basis for recruitment of translesion DNA polymerase Pol IV/DinB to the  -clamp journal November 2003
Did DNA replication evolve twice independently? journal September 1999
Bacteriophage Twort protein Gp168 is a β-clamp inhibitor by occupying the DNA sliding channel journal October 2021
ESPript/ENDscript: extracting and rendering sequence and 3D information from atomic structures of proteins journal July 2003
MUSCLE: multiple sequence alignment with high accuracy and high throughput journal March 2004
Dynamic assembly of Hda and the sliding clamp in the regulation of replication licensing journal February 2017
Binding of the regulatory domain of MutL to the sliding β-clamp is species specific journal March 2019
Phaser crystallographic software journal July 2007
The MORPHEUS protein crystallization screen journal November 2009
Model bias in macromolecular crystal structures journal November 1992
Flexibility revealed by the 1.85 Å crystal structure of the β sliding-clamp subunit of Escherichia coli DNA polymerase III journal June 2003
Towards rationalization of crystallization screening for small- to medium-sized academic laboratories: the PACT/JCSG+ strategy journal September 2005
Recent developments in classical density modification journal March 2010
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
Molecular replacement with MOLREP journal December 2009
XDS journal January 2010
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Features and development of Coot journal March 2010
Overview of the CCP 4 suite and current developments journal March 2011
Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination journal September 1998
Immobilized metal-affinity chromatography protein-recovery screening is predictive of crystallographic structure success journal August 2011
High-throughput protein production and purification at the Seattle Structural Genomics Center for Infectious Disease journal August 2011
MoRDa , an automatic molecular replacement pipeline journal August 2015
Two processivity clamp interactions differentially alter the dual activities of UmuC journal December 2005
Competition of bacteriophage polypeptides with native replicase proteins for binding to the DNA sliding clamp reveals a novel mechanism for DNA replication arrest in Staphylococcus aureus journal October 2006
Targeting DnaN for tuberculosis therapy using novel griselimycins journal June 2015
Cyclohexyl-griselimycin Is Active against Mycobacterium abscessus in Mice journal January 2022
Interaction of the Sliding Clamp β-Subunit and Hda, a DnaA-Related Protein journal June 2004
DNA Replication in Mycobacterium tuberculosis journal April 2017
The UmuC subunit of the E. coli DNA polymerase V shows a unique interaction with the β-clamp processivity factor journal July 2013
A new clustering and nomenclature for beta turns derived from high-resolution protein structures journal March 2019
Identification of β Clamp-DNA Interaction Regions That Impair the Ability of E. coli to Tolerate Specific Classes of DNA Damage journal September 2016
Architecture and Conservation of the Bacterial DNA Replication Machinery, an Underexploited Drug Target journal March 2012
Multi-target Parallel Processing Approach for Gene-to-structure Determination of the Influenza Polymerase PB2 Subunit journal June 2013
Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader journal February 2022