Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

Schenk, Simon; Sagendorf, Tyler J.; Many, Gina M.; Lira, Ana K.; de&nbsp;Sousa, Luis O.; Bae, Dam; Cicha, Michael; Kramer, Kyle S.; Muehlbauer, Michael; Hevener, Andrea L.; Rector, R. Scott; Thyfault, John P.; Williams, John P.; Goodyear, Laurie J.; Esser, Karyn A.; Newgard, Christopher B.; Bodine, Sue C.; Adkins, Joshua N.; Albertson, Brent G.; Amar, David; Amper, Mary S.; Ashley, Euan; Bae, Dam; Bamman, Marcas M.; Barnes, Jerry; Bergman, Bryan C.; Bessesen, Daniel H.; Bodine, Sue C.; Buford, Thomas W.; Burant, Charles F.; Cicha, Michael; Cutter, Gary R.; De&nbsp;Sousa, Luis Oliveria; Esser, Karyn A.; Fernández, Facundo M.; Gaul, David A.; Ge, Yongchao; Goodpaster, Bret H.; Goodyear, Laurie J.; Guevara, Kristy; Hevener, Andrea L.; Hirshman, Michael F.; Huffman, Kim M.; Jackson, Bailey E.; Jankowski, Catherine M.; Jimenez-Morales, David; Kohrt, Wendy M.; Kramer, Kyle S.; Kraus, William E.; Lessard, Sarah J.; Lester, Bridget; Lindholm, Malene E.; Lira, Ana K.; Many, Gina; Marjanovic, Nada; Marshall, Andrea G.; Melanson, Edward L.; Miller, Michael E.; Moreau, Kerrie L.; Nair, Venugopalan D.; Newgard, Christopher B.; Ortlund, Eric A.; Qian, Wei-Jun; Rasmussen, Blake B.; Rector, R. Scott; Richards, Collyn Z-T; Rushing, Scott; Sagendorf, Tyler J.; Sanford, James A.; Schauer, Irene E.; Schenk, Simon; Schwartz, Robert S.; Sealfon, Stuart C.; Seenarine, Nitish; Sparks, Lauren M.; Stowe, Cynthia L.; Talton, Jennifer W.; Teng, Christopher; Tesfa, Nathan D.; Thalacker-Mercer, Anna; Thyfault, John P.; Trappe, Scott; Trappe, Todd A.; Vasoya, Mital; Wheeler, Matthew T.; Walkup, Michael P.; Williams, John P.; Yan, Zhen; Zhen, Jimmy

doi:10.1093/function/zqae014

Title: Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)

Journal Article · 28 March 2024 · Function

DOI: https://doi.org/10.1093/function/zqae014 · OSTI ID:2479673

Schenk, Simon ^[1]; Sagendorf, Tyler J. ^[2]; Many, Gina M. ^[2]; Lira, Ana K. ^[3]; de Sousa, Luis O. ^[4]; Bae, Dam ^[3]; Cicha, Michael ^[3]; Kramer, Kyle S. ^[3]; Muehlbauer, Michael ^[5];

^[6]; Rector, R. Scott ^[7];

^[8]; Williams, John P. ^[9]; Goodyear, Laurie J. ^[10]; Esser, Karyn A. ^[11]; Newgard, Christopher B. ^[5];

^[4]; Adkins, Joshua N. ^[12]; Albertson, Brent G.; Amar, David more »

Univ. of San Diego, San Diego, CA (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of Iowa, Iowa City, IA (United States)
Univ. of Iowa, Iowa City, IA (United States); Oklahoma Medical Research Foundation (OMRF), Oklahoma City, OK (United States)
Duke Univ., Durham, NC (United States). Medical Center
Univ. of California, Los Angeles, CA (United States)
Harry S. Truman Memorial Veterans’ Medical Center, Columbia, MO (United States); Univ. of Missouri, Columbia, MO (United States)
University of Kansas Medical Center, Kansas City, KS (United States)
National Institutes of Health (NIH), Bethesda, MD (United States)
Harvard Medical School, Boston, MA (United States)
Univ. of Florida, Gainesville, FL (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); The MoTrPAC Study Group. et al.

While regular physical activity is a cornerstone of health, wellness, and vitality, the impact of endurance exercise training on molecular signaling within and across tissues remains to be delineated. The Molecular Transducers of Physical Activity Consortium (MoTrPAC) was established to characterize molecular networks underlying the adaptive response to exercise. Here, we describe the endurance exercise training studies undertaken by the Preclinical Animal Sites Studies component of MoTrPAC, in which we sought to develop and implement a standardized endurance exercise protocol in a large cohort of rats. To this end, Adult (6-mo) and Aged (18-mo) female (n = 151) and male (n = 143) Fischer 344 rats were subjected to progressive treadmill training (5 d/wk, ~70%–75% VO₂max) for 1, 2, 4, or 8 wk; sedentary rats were studied as the control group. A total of 18 solid tissues, as well as blood, plasma, and feces, were collected to establish a publicly accessible biorepository and for extensive omics-based analyses by MoTrPAC. Treadmill training was highly effective, with robust improvements in skeletal muscle citrate synthase activity in as little as 1–2 wk and improvements in maximum run speed and maximal oxygen uptake by 4–8 wk. For body mass and composition, notable age- and sex-dependent responses were observed. This work in mature, treadmill-trained rats represents the most comprehensive and publicly accessible tissue biorepository, to date, and provides an unprecedented resource for studying temporal-, sex-, and age-specific responses to endurance exercise training in a preclinical rat model.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Contributing Organization:: The MoTrPAC Study Group

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2479673

Report Number(s):: PNNL-SA--194543

Journal Information:: Function, Journal Name: Function Journal Issue: 4 Vol. 5; ISSN 2633-8823

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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