Lipoprotein Particles in Cerebrospinal Fluid

Tsujita, Maki; Melchior, John T.; Yokoyama, Shinji

doi:10.1161/atvbaha.123.318284

Title: Lipoprotein Particles in Cerebrospinal Fluid

Journal Article · 28 March 2024 · Arteriosclerosis, Thrombosis, and Vascular Biology

DOI: https://doi.org/10.1161/atvbaha.123.318284 · OSTI ID:2479447

^[1];

^[2]; Yokoyama, Shinji ^[3]

Nagoya City University (Japan)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Univ. of Cincinnati, OH (United States); Oregon Health & Science Univ., Portland, OR (United States)
Chubu University (Japan)

The brain is the most lipid-rich organ in the body, and the intricate interplay between lipid metabolism and pathologies associated with neurodegenerative disorders is being increasingly recognized. The brain is bathed in cerebrospinal fluid (CSF), which, like plasma, contains lipid-protein complexes called lipoproteins that are responsible for extracellular lipid transport. Multiple CSF lipoprotein populations exist, some of which are produced de novo in the central nervous system and others that appear to be generated from protein constituents that are produced in the periphery. These CSF lipoproteins are thought to play key roles in maintaining lipid homeostasis in the central nervous system, while little else is known due to their limited accessibility and their low abundance in CSF. Recent work has provided new insights into the compositional complexity of CSF lipoprotein families and their metabolism in cerebral circulation. Finally, the purpose of this review is to summarize our current state of knowledge on the composition, origin, and metabolism of CSF lipoproteins.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2479447

Report Number(s):: PNNL-SA--197441

Journal Information:: Arteriosclerosis, Thrombosis, and Vascular Biology, Journal Name: Arteriosclerosis, Thrombosis, and Vascular Biology Journal Issue: 5 Vol. 44; ISSN 1079-5642

Publisher:: American Heart Association, Inc.Copyright Statement

Country of Publication:: United States

Language:: English

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FGF-1 induces expression of LXRα and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes Lu, Rui; Ito, Jinichi; Iwamoto, Noriyuki Journal of Lipid Research, Vol. 50, Issue 6 https://doi.org/10.1194/jlr.M800594-JLR200	journal	June 2009
APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology Dickson, Dennis W.; Heckman, Michael G.; Murray, Melissa E. Neurology, Vol. 91, Issue 12 https://doi.org/10.1212/WNL.0000000000006212	journal	September 2018
Biomarkers for Severity of Spinal Cord Injury in the Cerebrospinal Fluid of Rats Lubieniecka, Joanna M.; Streijger, Femke; Lee, Jae H. T. PLoS ONE, Vol. 6, Issue 4 https://doi.org/10.1371/journal.pone.0019247	journal	April 2011
Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury Tzekov, Radouil; Dawson, Clint; Orlando, Megan PLOS ONE, Vol. 11, Issue 4 https://doi.org/10.1371/journal.pone.0153608	journal	April 2016
New insights of altered lipid profile in Fragile X Syndrome Çaku, Artuela; Seidah, Nabil G.; Lortie, Audrey PLOS ONE, Vol. 12, Issue 3 https://doi.org/10.1371/journal.pone.0174301	journal	March 2017
ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes Rawat, Varun; Wang, Shaowei; Sima, Jian The Journal of Neuroscience, Vol. 39, Issue 48 https://doi.org/10.1523/JNEUROSCI.1400-19.2019	journal	October 2019
Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function Karasinska, Joanna M.; Rinninger, Franz; Lütjohann, Dieter The Journal of Neuroscience, Vol. 29, Issue 11 https://doi.org/10.1523/JNEUROSCI.4741-08.2009	journal	March 2009
Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus Xu, Qin; Bernardo, Aubrey; Walker, David The Journal of Neuroscience, Vol. 26, Issue 19 https://doi.org/10.1523/JNEUROSCI.5476-05.2006	journal	May 2006
DNA Methylation in the Apolipoprotein-A1 Gene is Associated with Episodic Memory Performance in Healthy Older Individuals Lazarus, Jessica; Mather, Karen A.; Armstrong, Nicola J. Journal of Alzheimer's Disease, Vol. 44, Issue 1 https://doi.org/10.3233/JAD-141314	journal	January 2015
Reduced Cerebrospinal Fluid Concentration of Apolipoprotein A-I in Patients with Alzheimer’s Disease Johansson, Per; Almqvist, Erik G.; Bjerke, Maria Journal of Alzheimer's Disease, Vol. 59, Issue 3 https://doi.org/10.3233/JAD-170226	journal	July 2017
Post-Stroke Administration of L-4F Promotes Neurovascular and White Matter Remodeling in Type-2 Diabetic Stroke Mice Zhou, Min; Li, Rongwen; Venkat, Poornima Frontiers in Neurology, Vol. 13 https://doi.org/10.3389/fneur.2022.863934	journal	April 2022
Altered High Density Lipoprotein Composition in Behavioral Variant Frontotemporal Dementia Kim, Woojin Scott; He, Ying; Phan, Katherine Frontiers in Neuroscience, Vol. 12 https://doi.org/10.3389/fnins.2018.00847	journal	November 2018
ApoA-I Mimetic Peptide Reduces Vascular and White Matter Damage After Stroke in Type-2 Diabetic Mice Wang, Xiaohui; Li, Rongwen; Zacharek, Alex Frontiers in Neuroscience, Vol. 13 https://doi.org/10.3389/fnins.2019.01127	journal	October 2019
Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination Bruce, Kimberley D.; Gorkhali, Sachi; Given, Katherine Frontiers in Molecular Neuroscience, Vol. 11 https://doi.org/10.3389/fnmol.2018.00057	journal	March 2018
SR-BI Mediated Transcytosis of HDL in Brain Microvascular Endothelial Cells Is Independent of Caveolin, Clathrin, and PDZK1 Fung, Karen Y.; Wang, Changsen; Nyegaard, Steffen Frontiers in Physiology, Vol. 8 https://doi.org/10.3389/fphys.2017.00841	journal	October 2017
Lipoprotein Lipase Regulates Microglial Lipid Droplet Accumulation Loving, Bailey A.; Tang, Maoping; Neal, Mikaela C. Cells, Vol. 10, Issue 2 https://doi.org/10.3390/cells10020198	journal	January 2021
ABCA1 and Biogenesis of HDL Yokoyama, Shinji Journal of Atherosclerosis and Thrombosis, Vol. 13, Issue 1 https://doi.org/10.5551/jat.13.1	journal	January 2006
Selective Correction of Genotype Yield by Probucol in HDL-Deficient Mice Propagation Tsujita, Maki; Akita, Nobukatsu; Yokota, Tomo Journal of Atherosclerosis and Thrombosis, Vol. 27, Issue 1 https://doi.org/10.5551/jat.48967	journal	January 2020
Current Diagnosis and Management of Abetalipoproteinemia Takahashi, Manabu; Okazaki, Hiroaki; Ohashi, Ken Journal of Atherosclerosis and Thrombosis, Vol. 28, Issue 10 https://doi.org/10.5551/jat.RV17056	journal	October 2021
The Role of High-Density Lipoprotein in Lowering Risk of Dementia in the Elderly: A Review ., Anusheel; Avula, Supraja N.; Joseph, Ke-li-ta N. Cureus https://doi.org/10.7759/cureus.24374	journal	April 2022

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