Human limits in machine learning: prediction of potato yield and disease using soil microbiome data

Journal Article · 25 November 2024 · BMC Bioinformatics

DOI: https://doi.org/10.1186/s12859-024-05977-2 · OSTI ID:2478895

Aghdam, Rosa; Tang, Xudong; Shan, Shan; Lankau, Richard; Solís-Lemus, Claudia

Abstract Background The preservation of soil health is a critical challenge in the 21st century due to its significant impact on agriculture, human health, and biodiversity. We provide one of the first comprehensive investigations into the predictive potential of machine learning models for understanding the connections between soil and biological phenotypes. We investigate an integrative framework performing accurate machine learning-based prediction of plant performance from biological, chemical, and physical properties of the soil via two models: random forest and Bayesian neural network. Results Prediction improves when we add environmental features, such as soil properties and microbial density, along with microbiome data. Different preprocessing strategies show that human decisions significantly impact predictive performance. We show that the naive total sum scaling normalization that is commonly used in microbiome research is one of the optimal strategies to maximize predictive power. Also, we find that accurately defined labels are more important than normalization, taxonomic level, or model characteristics. ML performance is limited when humans can’t classify samples accurately. Lastly, we provide domain scientists via a full model selection decision tree to identify the human choices that optimize model prediction power. Conclusions Our study highlights the importance of incorporating diverse environmental features and careful data preprocessing in enhancing the predictive power of machine learning models for soil and biological phenotype connections. This approach can significantly contribute to advancing agricultural practices and soil health management.

• Sponsoring Organization: USDOE
• Grant/Contract Number: SC0021016
• OSTI ID: 2478895
• Journal Information: BMC Bioinformatics, Journal Name: BMC Bioinformatics Journal Issue: 1 Vol. 25; ISSN 1471-2105
• Publisher: Springer Science + Business MediaCopyright Statement
• Country of Publication: United Kingdom
• Language: English