Fe 3 O 4 nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

Fan, Xiaodong; Lv, Chunyang; Xue, Meiling; Meng, Peng; Qian, Xiaoping

doi:10.1080/19336918.2024.2427585

Title: Fe ₃ O ₄ nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

Journal Article · 12 November 2024 · Cell Adhesion & Migration

DOI: https://doi.org/10.1080/19336918.2024.2427585 · OSTI ID:2478753

Fan, Xiaodong ^[1]; Lv, Chunyang ^[2]; Xue, Meiling ^[3]; Meng, Peng ^[4]; Qian, Xiaoping ^[5]

Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China, Department of Thyroid and Breast Oncological Surgery, Xuzhou Medical College Affiliated Huaian Hospital, Huaian, China
Department of Hepatobiliary Surgery, Xuzhou Medical College Affiliated Huaian Hospital, Huaian, China
Department of Thyroid and Breast Oncological Surgery, Xuzhou Medical College Affiliated Huaian Hospital, Huaian, China
Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China, Department of Oncology, Yantai Hospital of Traditional Chinese Medicine, Yantai, China
Department of Oncology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, China

Not Available

View Journal Article

Cite

Export

Save

Sponsoring Organization:: USDOE EM Office of Technology Innovation and Development (EM-30)

OSTI ID:: 2478753

Journal Information:: Cell Adhesion & Migration, Journal Name: Cell Adhesion & Migration Journal Issue: 1 Vol. 18; ISSN 1933-6918

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

References (38)

Multiple Treatment of Triple‐Negative Breast Cancer Through Gambogic Acid‐Loaded Mesoporous Polydopamine Liu, Jiaqi; Liu, Hongmei; Huang, Shan Small, Vol. 20, Issue 31 https://doi.org/10.1002/smll.202309583	journal	March 2024
Microarray analyses reveal liver metastasis-related genes in metastatic colorectal cancer cell model Chen, Qiang; Chen, Lei; Zhao, Ren Journal of Cancer Research and Clinical Oncology, Vol. 139, Issue 7 https://doi.org/10.1007/s00432-013-1424-2	journal	April 2013
The crucial role of emilin 1 gene expression during progression of tumor growth Rabajdova, Miroslava; Urban, Peter; Spakova, Ivana Journal of Cancer Research and Clinical Oncology, Vol. 142, Issue 11 https://doi.org/10.1007/s00432-016-2226-0	journal	August 2016
Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics Hatami, Elham; Jaggi, Meena; Chauhan, Subhash C. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Vol. 1874, Issue 1 https://doi.org/10.1016/j.bbcan.2020.188381	journal	August 2020
Engineered nano-immunopotentiators efficiently promote cancer immunotherapy for inhibiting and preventing lung metastasis of melanoma Luo, Lijia; Iqbal, Muhammad Zubair; Liu, Chuang Biomaterials, Vol. 223 https://doi.org/10.1016/j.biomaterials.2019.119464	journal	December 2019
Current status of nanoscale drug delivery systems for colorectal cancer liver metastasis Hong, Yun; Rao, Yuefeng Biomedicine & Pharmacotherapy, Vol. 114 https://doi.org/10.1016/j.biopha.2019.108764	journal	June 2019
Gambogic acid exhibits anti-metastatic activity on malignant melanoma mainly through inhibition of PI3K/Akt and ERK signaling pathways Li, Chun-yu; Wang, Qi; Wang, Xiao-min European Journal of Pharmacology, Vol. 864 https://doi.org/10.1016/j.ejphar.2019.172719	journal	December 2019
Abrogation of EMILIN1-β1 integrin interaction promotes experimental colitis and colon carcinogenesis Capuano, Alessandra; Pivetta, Eliana; Sartori, Giulio Matrix Biology, Vol. 83 https://doi.org/10.1016/j.matbio.2019.08.006	journal	October 2019
Whole-Genome DNA Methylation Profiling Identifies Epigenetic Signatures of Uterine Carcinosarcoma Li, Jing; Xing, Xiaoyun; Li, Daofeng Neoplasia, Vol. 19, Issue 2 https://doi.org/10.1016/j.neo.2016.12.009	journal	February 2017
An in vivo functional genomics screen of nuclear receptors and their co-regulators identifies FOXA1 as an essential gene in lung tumorigenesis Hight, Suzie K.; Mootz, Allison; Kollipara, Rahul K. Neoplasia, Vol. 22, Issue 8 https://doi.org/10.1016/j.neo.2020.04.005	journal	August 2020
Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK Zhao, Qun; Zhong, Jing; Bi, Yun Phytomedicine, Vol. 78 https://doi.org/10.1016/j.phymed.2020.153306	journal	November 2020
Gambogic acid exhibits promising anticancer activity by inhibiting the pentose phosphate pathway in lung cancer mouse model Zhang, Qianyu; Zhang, Ying; Wang, Chen Phytomedicine, Vol. 129 https://doi.org/10.1016/j.phymed.2024.155657	journal	July 2024
Metastatic colorectal cancer: mechanisms and emerging therapeutics Shin, Alice E.; Giancotti, Filippo G.; Rustgi, Anil K. Trends in Pharmacological Sciences, Vol. 44, Issue 4 https://doi.org/10.1016/j.tips.2023.01.003	journal	April 2023
Iron Oxide Nanoparticles Inhibit Tumor Progression and Suppress Lung Metastases in Mouse Models of Breast Cancer Korangath, Preethi; Jin, Lu; Yang, Chun-Ting ACS Nano, Vol. 18, Issue 15 https://doi.org/10.1021/acsnano.3c12064	journal	April 2024
REV-ERB and ROR nuclear receptors as drug targets Kojetin, Douglas J.; Burris, Thomas P. Nature Reviews Drug Discovery, Vol. 13, Issue 3 https://doi.org/10.1038/nrd4100	journal	February 2014
Colorectal liver metastasis: molecular mechanism and interventional therapy Zhou, Hui; Liu, Zhongtao; Wang, Yongxiang Signal Transduction and Targeted Therapy, Vol. 7, Issue 1 https://doi.org/10.1038/s41392-022-00922-2	journal	March 2022
Loss of the extracellular matrix glycoprotein EMILIN1 accelerates Δ16HER2-driven breast cancer initiation in mice Favero, Andrea; Segatto, Ilenia; Capuano, Alessandra npj Breast Cancer, Vol. 10, Issue 1 https://doi.org/10.1038/s41523-023-00608-0	journal	January 2024
Zoledronate and SPIO dual-targeting nanoparticles loaded with ICG for photothermal therapy of breast cancer tibial metastasis Jiang, Zichao; Li, Jingyi; Chen, Sijie Scientific Reports, Vol. 10, Issue 1 https://doi.org/10.1038/s41598-020-70659-x	journal	August 2020
The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells Islam, S. M. Anisul; Patel, Rekha; Bommareddy, Raja Reddy Cell Adhesion & Migration, Vol. 13, Issue 1 https://doi.org/10.1080/19336918.2018.1546513	journal	November 2018
Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ Wen, Zhenzhen; Pan, Tianhui; Yang, Saisai Molecular Cancer, Vol. 16, Issue 1 https://doi.org/10.1186/s12943-017-0590-2	journal	January 2017
Colorectal cancer development is affected by the ECM molecule EMILIN-2 hinging on macrophage polarization via the TLR-4/MyD88 pathway Andreuzzi, Eva; Fejza, Albina; Polano, Maurizio Journal of Experimental & Clinical Cancer Research, Vol. 41, Issue 1 https://doi.org/10.1186/s13046-022-02271-y	journal	February 2022
Iron oxide magnetic nanoparticles combined with actein suppress non-small-cell lung cancer growth in a p53-dependent manner Wang, Mingshan; Chen, Liang; Xiong, Ya-Qiong International Journal of Nanomedicine, Vol. Volume 12 https://doi.org/10.2147/IJN.S127549	journal	October 2017
Study of the enhanced anticancer efficacy of gambogic acid on Capan-1 pancreatic cancer cells when mediated via magnetic Fe3O4 nanoparticles Chen, Baoan; Cailian, Wang; Zhang, Haijun International Journal of Nanomedicine https://doi.org/10.2147/IJN.S24707	journal	September 2011
Gambogic Acid as a Candidate for Cancer Therapy: A Review Liu, Yuling; Chen, Yingchong; Lin, Longfei International Journal of Nanomedicine, Vol. Volume 15 https://doi.org/10.2147/IJN.S277645	journal	December 2020
Gambogic acid-loaded magnetic Fe3O4 nanoparticles inhibit Panc-1 pancreatic cancer cell proliferation and migration by inactivating transcription factor ETS1 Chen, Baoan; Cailian, Wang; Zhang, Haijun International Journal of Nanomedicine https://doi.org/10.2147/IJN.S28509	journal	February 2012
Synergistic effect of a combination of nanoparticulate Fe3O4 and gambogic acid on phosphatidylinositol 3-kinase/Akt/Bad pathway of LOVO cells Chen, Baoan; Fang, Lianghua; Liu, Shenlin International Journal of Nanomedicine https://doi.org/10.2147/IJN.S32475	journal	July 2012
Effects of magnetic nanoparticles of Fe3O4 combinated with gambogic acid on apoptosis of SMMC-7721 cells Chen, Baoan; Tian, Liang; Cheng, Jian OncoTargets and Therapy https://doi.org/10.2147/OTT.S86494	journal	August 2015
Emerging mechanisms progress of colorectal cancer liver metastasis Zhao, Wenhu; Dai, Shipeng; Yue, Lei Frontiers in Endocrinology, Vol. 13 https://doi.org/10.3389/fendo.2022.1081585	journal	December 2022
The EMILIN/Multimerin Family Colombatti, Alfonso; Spessotto, Paola; Doliana, Roberto Frontiers in Immunology, Vol. 2 https://doi.org/10.3389/fimmu.2011.00093	journal	January 2012
Gambogic Acid Induces Pyroptosis of Colorectal Cancer Cells through the GSDME-Dependent Pathway and Elicits an Antitumor Immune Response Xu, Hanjie; Zhang, Danya; Wei, Rui Cancers, Vol. 14, Issue 22 https://doi.org/10.3390/cancers14225505	journal	November 2022
Loss of Multimerin-2 and EMILIN-2 Expression in Gastric Cancer Associate with Altered Angiogenesis Andreuzzi, Eva; Capuano, Alessandra; Pellicani, Rosanna International Journal of Molecular Sciences, Vol. 19, Issue 12 https://doi.org/10.3390/ijms19123983	journal	December 2018
Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis Amor López, Ana; Mazariegos, Marina S.; Capuano, Alessandra International Journal of Molecular Sciences, Vol. 22, Issue 14 https://doi.org/10.3390/ijms22147406	journal	July 2021
Theranostics Nanomedicine Applications for Colorectal Cancer and Metastasis: Recent Advances Kasi, Phanindra Babu; Mallela, Venkata Ramana; Ambrozkiewicz, Filip International Journal of Molecular Sciences, Vol. 24, Issue 9 https://doi.org/10.3390/ijms24097922	journal	April 2023
Research Progress in the Field of Gambogic Acid and Its Derivatives as Antineoplastic Drugs Li, Meng; Su, Fali; Zhu, Mingtao Molecules, Vol. 27, Issue 9 https://doi.org/10.3390/molecules27092937	journal	May 2022
Retinoic acid-related orphan receptor RORβ, circadian rhythm abnormalities and tumorigenesis (Review) Feng, Shujiong; Xu, Song; Wen, Zhenzhen International Journal of Molecular Medicine, Vol. 35, Issue 6 https://doi.org/10.3892/ijmm.2015.2155	journal	March 2015
Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells Wen, Chuangyu; Huang, Lanlan; Chen, Junxiong International Journal of Oncology, Vol. 47, Issue 5 https://doi.org/10.3892/ijo.2015.3166	journal	September 2015
RORβ suppresses the stemness of gastric cancer cells by downregulating the activity of the Wnt signaling pathway Wen, Zhenzhen; Chen, Ming; Guo, Wenhao Oncology Reports, Vol. 46, Issue 2 https://doi.org/10.3892/or.2021.8131	journal	July 2021
Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics Zhao, Shengzhe; Yu, Xujiang; Qian, Yuna Theranostics, Vol. 10, Issue 14 https://doi.org/10.7150/thno.42564	journal	January 2020

Similar Records

TRIM16 overexpression inhibits the metastasis of colorectal cancer through mediating Snail degradation

Journal Article · 2021 · Experimental Cell Research · OSTI ID:23195545

Ruan, Longhui; Liu, Weifeng; Yang, Yanhui; +4 more

A miR-124/ITGA3 axis contributes to colorectal cancer metastasis by regulating anoikis susceptibility

Journal Article · 2018 · Biochemical and Biophysical Research Communications · OSTI ID:23137012

Sa, Ke-di; Zhang, Xiang; Li, Xiao-fei; +5 more

Ultrasonic synthesis of polyaniline nanotubes containing Fe{sub 3}O{sub 4} nanoparticles

Journal Article · 2006 · Journal of Solid State Chemistry · OSTI ID:20905416

Xiaofeng, Lu; Mao, Hui; Danming, Chao; +2 more

Title: Fe 3 O 4 nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis

Citation Formats

References (38)

Similar Records

Related Subjects

Title: Fe ₃ O ₄ nanoparticles containing gambogic acid inhibit metastasis in colorectal cancer via the RORB/EMILIN1 axis