Protein data bank: From two epidemics to the global pandemic to mRNA vaccines and Paxlovid

Burley, Stephen K.

doi:10.1016/j.sbi.2024.102954

Title: Protein data bank: From two epidemics to the global pandemic to mRNA vaccines and Paxlovid

Journal Article · 24 November 2024 · Current Opinion in Structural Biology

DOI: https://doi.org/10.1016/j.sbi.2024.102954 · OSTI ID:2478573

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Rutgers Univ., Piscataway, NJ (United States); Rutgers Univ., New Brunswick, NJ (United States); Univ. of California, San Diego, CA (United States)

Structural biologists and the open-access Protein Data Bank (PDB) played decisive roles in combating the COVID-19 pandemic. Global biostructure data were turned into global knowledge, allowing scientists and engineers to understand the inner workings of coronaviruses and develop effective countermeasures. Two mRNA vaccines, initially designed with guidance from PDB structures of the SARS-CoV-1 and MERS-CoV spike proteins, prevented infections entirely or reduced the likelihood of morbidity and mortality for more than five billion individual recipients worldwide. Structure-guided drug discovery by Pfizer, Inc (facilitated by PDB structures), initiated in the 2000s in response to SARS-CoV-1 and resumed in 2020, yielded nirmatrelvir (the active ingredient of Paxlovid) -- a potent, orally-bioavailable inhibitor of the SARS-CoV-2 main protease. You've got to love the Protein Data Bank!

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Research Organization:: Rutgers Univ., Piscataway, NJ (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0019749

OSTI ID:: 2478573

Journal Information:: Current Opinion in Structural Biology, Journal Name: Current Opinion in Structural Biology Vol. 90; ISSN 0959-440X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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