Extended conformations of bifurcating electron transfer flavoprotein constitute up to half the population, possibly mediating conformational change

Khan, Sharique A.; Hicks, Alan; Leite, Wellington C.; Byrnes, James; Gorai, Biswajit; Mroginski, Maria-Andrea; O'Neill, Hugh; Miller, Anne-Frances

doi:10.1039/D4SC04544K

Title: Extended conformations of bifurcating electron transfer flavoprotein constitute up to half the population, possibly mediating conformational change

Journal Article · 19 November 2024 · Chemical Science

DOI: https://doi.org/10.1039/D4SC04544K · OSTI ID:2478047

^[1]; Hicks, Alan ^[2]; Leite, Wellington C. ^[2]; Byrnes, James ^[3]; Gorai, Biswajit ^[4];

^[4]; O'Neill, Hugh ^[2];

^[5]

Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA, Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA
National Synchrotron Light Source II, Brookhaven National Laboratory, Upton, NY 11973, USA
Department of Chemistry, Technische Universität Berlin, 10623 Berlin, Germany
Department of Chemistry, University of Kentucky, Lexington, KY 40506, USA

Small-angle neutron scattering shows that electron transfer flavoprotein in solution populates extended conformations that are distinct from crystal structures. Extended conformations could mediate conformation changes that gate electron transfer.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: NONE; SC0021283; SC0012704

OSTI ID:: 2478047

Journal Information:: Chemical Science, Journal Name: Chemical Science Journal Issue: 45 Vol. 15; ISSN 2041-6520; ISSN CSHCBM

Publisher:: Royal Society of Chemistry (RSC)Copyright Statement

Country of Publication:: United Kingdom

Language:: English

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Journal Article · 2019 · Journal of Structural Biology · OSTI ID:1545231

Tavolieri, Angela M.; Murray, Daniel T.; Askenasy, Isabel; +4 more

Title: Extended conformations of bifurcating electron transfer flavoprotein constitute up to half the population, possibly mediating conformational change

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