Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales

Ennis, Amanda F.; Cochrane, C. Skyler; Dome, Patrick A.; Jeong, Pyeonghwa; Yu, Jincheng; Lee, Hyejin; Williams, Carly S.; Ha, Yang; Yang, Weitao; Zhou, Pei; Hong, Jiyong

doi:10.1021/jacsau.4c00731

Title: Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales

Journal Article · 11 November 2024 · JACS Au

DOI: https://doi.org/10.1021/jacsau.4c00731 · OSTI ID:2476876

Ennis, Amanda F. ^[1]; Cochrane, C. Skyler ^[2]; Dome, Patrick A. ^[1]; Jeong, Pyeonghwa ^[1];

^[1]; Lee, Hyejin ^[1]; Williams, Carly S. ^[3];

^[4];

^[1];

^[2];

^[5]

Department of Chemistry, Duke University, Durham, North Carolina 27708, United States
Department of Chemistry, Duke University, Durham, North Carolina 27708, United States, Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States
Department of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States
Berkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States
Department of Chemistry, Duke University, Durham, North Carolina 27708, United States, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, North Carolina 27710, United States

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231; AC02-06CH11357

OSTI ID:: 2476876

Journal Information:: JACS Au, Journal Name: JACS Au Journal Issue: 11 Vol. 4; ISSN 2691-3704

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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