Catalyzing the future: recent advances in chemical synthesis using enzymes

Reisenbauer, Julia C.; Sicinski, Kathleen M.; Arnold, Frances H.

doi:10.1016/j.cbpa.2024.102536

Title: Catalyzing the future: recent advances in chemical synthesis using enzymes

Journal Article · 05 October 2024 · Current Opinion in Chemical Biology

DOI: https://doi.org/10.1016/j.cbpa.2024.102536 · OSTI ID:2476179

^[1]; Sicinski, Kathleen M. ^[1]; Arnold, Frances H. ^[1]

California Institute of Technology (CalTech), Pasadena, CA (United States)

Biocatalysis has the potential to address the need for more sustainable organic synthesis routes. Pro-tein engineering can tune enzymes to perform in cascade reactions and for efficient synthesis of en-antiomerically enriched compounds, using both natural and new-to-nature reaction pathways. This review highlights recent achievements in biocatal-ysis, especially the development of novel enzymatic syntheses to access versatile small molecule inter-mediates and complex biomolecules. Biocatalytic strategies for the degradation of persistent pollu-tants and approaches for biomass valorization are also discussed. Here, the transition of chemical synthesis to a greener future will be accelerated by imple-menting enzymes and engineering them for high performance and new activities.

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Research Organization:: California Institute of Technology (CalTech), Pasadena, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: SC0021141

OSTI ID:: 2476179

Journal Information:: Current Opinion in Chemical Biology, Journal Name: Current Opinion in Chemical Biology Vol. 83; ISSN 1367-5931

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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