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Title: Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction

Journal Article · · Structure

Not Available

Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
OSTI ID:
2475684
Journal Information:
Structure, Journal Name: Structure Journal Issue: 11 Vol. 32; ISSN 0969-2126
Publisher:
ElsevierCopyright Statement
Country of Publication:
United Kingdom
Language:
English

References (75)

The HP1a Disordered C Terminus and Chromo Shadow Domain Cooperate to Select Target Peptide Partners journal April 2011
UCSF ChimeraX : Structure visualization for researchers, educators, and developers journal October 2020
SEDNTERP: a calculation and database utility to aid interpretation of analytical ultracentrifugation and light scattering data journal February 2023
Nucleosome core particle stability and conformational change journal June 1984
Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling journal March 2000
Reconstitution of Nucleosome Core Particles from Recombinant Histones and DNA book January 2003
The Site-Specific Installation of Methyl-Lysine Analogs into Recombinant Histones journal March 2007
Histone variants and chromatin structure, update of advances journal January 2023
Hinge and Chromoshadow of HP1α Participate in Recognition of K9 Methylated Histone H3 in Nucleosomes journal January 2013
Structure and Function of Chromatin Remodelers journal July 2021
CTFFIND4: Fast and accurate defocus estimation from electron micrographs journal November 2015
CryoFold: Determining protein structures and data-guided ensembles from cryo-EM density maps journal October 2021
H2A.Z Alters the Nucleosome Surface to Promote HP1α-Mediated Chromatin Fiber Folding journal November 2004
Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin journal August 2005
ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin journal July 2008
Chromodomain-Mediated Oligomerization of HP1 Suggests a Nucleosome-Bridging Mechanism for Heterochromatin Assembly journal January 2011
Structural Basis of Heterochromatin Formation by Human HP1 journal February 2018
Structural transition of the nucleosome during chromatin remodeling and transcription journal December 2019
Unraveling linker histone interactions in nucleosomes journal December 2021
Post-translational modifications of the histone variant h2az journal January 2014
Crystal Structure of the HP1-EMSY Complex Reveals an Unusual Mode of HP1 Binding journal April 2006
Mechanisms of functional promiscuity by HP1 proteins journal June 2014
Crystal structure of the nucleosome core particle at 2.8 Å resolution journal September 1997
Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure: Human mitotic chromosomes consist of nucleosome fibres journal February 2012
Open and closed domains in the mouse genome are configured as 10-nm chromatin fibres journal September 2012
HP1-β mobilization promotes chromatin changes that initiate the DNA damage response journal April 2008
A conformational switch in HP1 releases auto-inhibition to drive heterochromatin assembly journal March 2013
Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin journal June 2017
Phase separation drives heterochromatin domain formation journal June 2017
Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9 journal February 2002
Comprehensive identification of peptides in tandem mass spectra using an efficient open search engine journal October 2018
Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin journal April 2016
Higher-order structure in pericentric heterochromatin involves a distinct pattern of histone modification and an RNA component journal February 2002
NIH Image to ImageJ: 25 years of image analysis journal June 2012
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination journal February 2017
GraFix: sample preparation for single-particle electron cryomicroscopy journal December 2007
HP1 and the dynamics of heterochromatin maintenance journal April 2004
Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics journal October 2012
RNA interference demonstrates a novel role for H2A.Z in chromosome segregation journal June 2004
A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides journal July 2019
HP1 reshapes nucleosome core to promote phase separation of heterochromatin journal October 2019
Highly accurate protein structure prediction with AlphaFold journal July 2021
Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs journal October 2019
Sin mutations alter inherent nucleosome mobility journal January 2004
H2A.Z contributes to the unique 3D structure of the centromere journal December 2006
Isoform-specific interaction of HP1 with human TAFII130 journal April 2002
Determining protein structures by combining semireliable data with atomistic physical models by Bayesian inference journal May 2015
Heterochromatin Protein 1 Binds to Nucleosomes and DNA in Vitro journal September 2000
Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1 journal April 2017
Heterochromatin protein 1 is recruited to various types of DNA damage journal May 2009
Mitotic centromeric targeting of HP1 and its binding to Sgo1 are dispensable for sister-chromatid cohesion in human cells journal April 2011
Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1 α journal October 2002
The structure of mouse HP1 suggests a unique mode of single peptide recognition by the shadow chromo domain dimer journal April 2000
Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3 journal September 2001
HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomain journal June 2003
AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models journal November 2021
Structural basis of chromatin regulation by histone variant H2A.Z journal October 2021
The interplay between H2A.Z and H3K9 methylation in regulating HP1α binding to linker histone-containing chromatin journal July 2018
CBX3 regulates efficient RNA processing genome-wide journal June 2012
Features and development of Coot journal March 2010
Structure of HP1 Chromodomain Bound to a Lysine 9-Methylated Histone H3 Tail journal February 2002
Cryo-EM Study of the Chromatin Fiber Reveals a Double Helix Twisted by Tetranucleosomal Units journal April 2014
Spheroid Chromatin Units (ngr Bodies) journal January 1974
Chromatin Structure: Oligomers of the Histones: The histones comprise an (F2A1) 2 (F3) 2 tetramer, a different oligomer of F2A2 and F2B, and monomer of F1. journal May 1974
Chromatin Structure: A Repeating Unit of Histones and DNA journal May 1974
ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells journal July 2017
Histone Tails and the H3 αN Helix Regulate Nucleosome Mobility and Stability journal March 2007
The Hinge and Chromo Shadow Domain Impart Distinct Targeting of HP1-Like Proteins journal April 2001
Cell cycle behavior of human HP1 subtypes: distinct molecular domains of HP1 are required for their centromeric localization during interphase and metaphase journal August 2003
Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2 journal October 2020
Macromolecular Size-and-Shape Distributions by Sedimentation Velocity Analytical Ultracentrifugation journal June 2006
Insights into HP1a-Chromatin Interactions journal August 2020
Collaboration gets the most out of software journal September 2013
Molecular dynamics-based refinement and validation for sub-5 Å cryo-electron microscopy maps journal July 2016
New tools for automated high-resolution cryo-EM structure determination in RELION-3 journal November 2018