BGC Atlas: a web resource for exploring the global chemical diversity encoded in bacterial genomes

Bağcı, Caner; Nuhamunada, Matin; Goyat, Hemant; Ladanyi, Casimir; Sehnal, Ludek; Blin, Kai; Kautsar, Satria A.; Tagirdzhanov, Azat; Gurevich, Alexey; Mantri, Shrikant; von Mering, Christian; Udwary, Daniel; Medema, Marnix H.; Weber, Tilmann; Ziemert, Nadine

doi:10.1093/nar/gkae953

Title: BGC Atlas: a web resource for exploring the global chemical diversity encoded in bacterial genomes

Journal Article · 29 October 2024 · Nucleic Acids Research

DOI: https://doi.org/10.1093/nar/gkae953 · OSTI ID:2475209

Bağcı, Caner;

; Goyat, Hemant; Ladanyi, Casimir; Sehnal, Ludek;

; Kautsar, Satria A.; Tagirdzhanov, Azat; Gurevich, Alexey; Mantri, Shrikant; von Mering, Christian;

;

Abstract Secondary metabolites are compounds not essential for an organism’s development, but provide significant ecological and physiological benefits. These compounds have applications in medicine, biotechnology and agriculture. Their production is encoded in biosynthetic gene clusters (BGCs), groups of genes collectively directing their biosynthesis. The advent of metagenomics has allowed researchers to study BGCs directly from environmental samples, identifying numerous previously unknown BGCs encoding unprecedented chemistry. Here, we present the BGC Atlas (https://bgc-atlas.cs.uni-tuebingen.de), a web resource that facilitates the exploration and analysis of BGC diversity in metagenomes. The BGC Atlas identifies and clusters BGCs from publicly available datasets, offering a centralized database and a web interface for metadata-aware exploration of BGCs and gene cluster families (GCFs). We analyzed over 35 000 datasets from MGnify, identifying nearly 1.8 million BGCs, which were clustered into GCFs. The analysis showed that ribosomally synthesized and post-translationally modified peptides are the most abundant compound class, with most GCFs exhibiting high environmental specificity. We believe that our tool will enable researchers to easily explore and analyze the BGC diversity in environmental samples, significantly enhancing our understanding of bacterial secondary metabolites, and promote the identification of ecological and evolutionary factors shaping the biosynthetic potential of microbial communities.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2475209

Journal Information:: Nucleic Acids Research, Journal Name: Nucleic Acids Research Journal Issue: D1 Vol. 53; ISSN 0305-1048

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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