Post-translational modifications: emerging directors of cell-fate decisions during endoplasmic reticulum stress in Arabidopsis thaliana

Thibault, Ethan; Brandizzi, Federica

doi:10.1042/bst20231025

Title: Post-translational modifications: emerging directors of cell-fate decisions during endoplasmic reticulum stress in Arabidopsis thaliana

Journal Article · 11 April 2024 · Biochemical Society Transactions

DOI: https://doi.org/10.1042/bst20231025 · OSTI ID:2473231

Thibault, Ethan ^[1];

^[1]

Michigan State University, East Lansing, MI (United States)

Homeostasis of the endoplasmic reticulum (ER) is critical for growth, development, and stress responses. Perturbations causing an imbalance in ER proteostasis lead to a potentially lethal condition known as ER stress. In ER stress situations, cell-fate decisions either activate pro-life pathways that reestablish homeostasis or initiate pro-death pathways to prevent further damage to the organism. Understanding the mechanisms underpinning cell-fate decisions in ER stress is critical for crop development and has the potential to enable translation of conserved components to ER stress-related diseases in metazoans. Post-translational modifications (PTMs) of proteins are emerging as key players in cell-fate decisions in situations of imbalanced ER proteostasis. In this review, we address PTMs orchestrating cell-fate decisions in ER stress in plants and provide evidence-based perspectives for where future studies may focus to identify additional PTMs involved in ER stress management.

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Research Organization:: Great Lakes Bioenergy Research Center (GLBRC), Madison, WI (United States); Michigan State University, East Lansing, MI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division (CSGB); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: FG02-91ER20021; SC0018409

OSTI ID:: 2473231

Journal Information:: Biochemical Society Transactions, Journal Name: Biochemical Society Transactions Journal Issue: 2 Vol. 52; ISSN 0300-5127

Publisher:: Portland PressCopyright Statement

Country of Publication:: United States

Language:: English

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