Naloxone-initiated mechanochemical synthesis of poly(lactic acid)

Journal Article · 01 January 2025 · RSC Mechanochemistry

DOI: https://doi.org/10.1039/D4MR00046C · OSTI ID:2473176

Ebqa'ai, Mohammad A. ^[1]; Kasthuri Dias, Sandun Bogahawaththa ^[2]; Kassick, Andrew J. ^[3]; Averick, Saadyah ^[3]; Nelson, Toby L.  ^[4]

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1. Department of Chemistry, Physics, and Engineering, Cameron University, Lawton, Oklahoma 73505, USA, Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, USA
2. Oak Ridge Innovation Institute, The University of Tennessee, Knoxville, TN 37996, USA
3. Neuroscience Institute, Allegheny Health Network, Allegheny General Hospital, Pittsburgh, PA 15212, USA
4. Oak Ridge Innovation Institute, The University of Tennessee, Knoxville, TN 37996, USA, Department of Chemistry, Oklahoma State University, Stillwater, Oklahoma 74078, USA

Herein is an one-pot mechanosynthesis of naloxone covalently linked poly(lactic acid) and nanoparticles (∼600 nm) with a drug loading (∼8.3% w/w).

• Sponsoring Organization: USDOE
• Grant/Contract Number: NONE; EE0009177
• OSTI ID: 2473176
• Journal Information: RSC Mechanochemistry, Journal Name: RSC Mechanochemistry; ISSN 2976-8683; ISSN RMSED4
• Publisher: Royal Society of Chemistry (RSC)Copyright Statement
• Country of Publication: Country unknown/Code not available
• Language: English