High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota

Lee, Jee-Yon; Tiffany, Connor R.; Mahan, Scott P.; Kellom, Matthew; Rogers, Andrew W.L.; Nguyen, Henry; Stevens, Eric T.; Masson, Hugo L.P.; Yamazaki, Kohei; Marco, Maria L.; Eloe-Fadrosh, Emiley A.; Turnbaugh, Peter J.; Bäumler, Andreas J.

doi:10.1016/j.cell.2024.01.029

Title: High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota

Journal Article · 15 February 2024 · Cell

DOI: https://doi.org/10.1016/j.cell.2024.01.029 · OSTI ID:2472913

Lee, Jee-Yon ^[1]; Tiffany, Connor R. ^[1]; Mahan, Scott P. ^[1]; Kellom, Matthew ^[2]; Rogers, Andrew W.L. ^[1]; Nguyen, Henry ^[1]; Stevens, Eric T. ^[1]; Masson, Hugo L.P. ^[1]; Yamazaki, Kohei ^[3]; Marco, Maria L. ^[1]; Eloe-Fadrosh, Emiley A. ^[2]; Turnbaugh, Peter J. ^[4]; Bäumler, Andreas J. ^[1]

Univ. of California, Davis, CA (United States)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Univ. of California, Davis, CA (United States); Kitasato University, Towada (Japan)
Univ. of California, San Francisco, CA (United States); Chan Zuckerberg Biohub, San Francisco, CA (United States)

Carbohydrate intolerance, commonly linked to the consumption of lactose, fructose, or sorbitol, affects up to 30% of the population in high-income countries. Although sorbitol intolerance is attributed to malabsorption, the underlying mechanism remains unresolved. Here, we show that a history of antibiotic exposure combined with high fat intake triggered long-lasting sorbitol intolerance in mice by reducing Clostridia abundance, which impaired microbial sorbitol catabolism. The restoration of sorbitol catabolism by inoculation with probiotic Escherichia coli protected mice against sorbitol intolerance but did not restore Clostridia abundance. Inoculation with the butyrate producer Anaerostipes caccae restored a normal Clostridia abundance, which protected mice against sorbitol-induced diarrhea even when the probiotic was cleared. Butyrate restored Clostridia abundance by stimulating epithelial peroxisome proliferator-activated receptor-gamma (PPAR-γ) signaling to restore epithelial hypoxia in the colon. Collectively, these mechanistic insights identify microbial sorbitol catabolism as a potential target for approaches for the diagnosis, treatment, and prevention of sorbitol intolerance.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); National Science Foundation (NSF); National Institutes of Health (NIH); Centers for Disease Control and Prevention (CDC); Crohn’s & Colitis Foundation; Kenneth Rainin Foundation

Grant/Contract Number:: AC02-05CH11231; 89233218CNA000001; AC05-76RL01830

OSTI ID:: 2472913

Journal Information:: Cell, Journal Name: Cell Journal Issue: 5 Vol. 187; ISSN 0092-8674

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
Clostridiagut microbiota
antibiotics
carbohydrate intolerance
high-fat diet
polyolsorbitol intolerance

Title: High fat intake sustains sorbitol intolerance after antibiotic-mediated Clostridia depletion from the gut microbiota

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References (81)

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