Harnessing genetic engineering to drive economic bioproduct production in algae

Gupta, Abhishek; Kang, Kalisa; Pathania, Ruchi; Saxton, Lisa; Saucedo, Barbara; Malik, Ashleyn; Torres-Tiji, Yasin; Diaz, Crisandra J.; Dutra Molino, João Vitor; Mayfield, Stephen P.

doi:10.3389/fbioe.2024.1350722

Title: Harnessing genetic engineering to drive economic bioproduct production in algae

Journal Article · 29 January 2024 · Frontiers in Bioengineering and Biotechnology

DOI: https://doi.org/10.3389/fbioe.2024.1350722 · OSTI ID:2472224

Gupta, Abhishek ^[1]; Kang, Kalisa ^[2]; Pathania, Ruchi ^[2]; Saxton, Lisa ^[2]; Saucedo, Barbara ^[2]; Malik, Ashleyn ^[2]; Torres-Tiji, Yasin ^[2]; Diaz, Crisandra J. ^[2]; Dutra Molino, João Vitor ^[2]; Mayfield, Stephen P. ^[2]

University of California, San Diego, CA (United States); OSTI
University of California, San Diego, CA (United States)

Our reliance on agriculture for sustenance, healthcare, and resources has been essential since the dawn of civilization. However, traditional agricultural practices are no longer adequate to meet the demands of a burgeoning population amidst climate-driven agricultural challenges. Microalgae emerge as a beacon of hope, offering a sustainable and renewable source of food, animal feed, and energy. Their rapid growth rates, adaptability to non-arable land and non-potable water, and diverse bioproduct range, encompassing biofuels and nutraceuticals, position them as a cornerstone of future resource management. Furthermore, microalgae’s ability to capture carbon aligns with environmental conservation goals. While microalgae offers significant benefits, obstacles in cost-effective biomass production persist, which curtails broader application. This review examines microalgae compared to other host platforms, highlighting current innovative approaches aimed at overcoming existing barriers. These approaches include a range of techniques, from gene editing, synthetic promoters, and mutagenesis to selective breeding and metabolic engineering through transcription factors.

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Research Organization:: University of California, San Diego, CA (United States)

Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE)

Grant/Contract Number:: EE0009671

OSTI ID:: 2472224

Journal Information:: Frontiers in Bioengineering and Biotechnology, Journal Name: Frontiers in Bioengineering and Biotechnology Vol. 12; ISSN 2296-4185

Publisher:: Frontiers Media S.A.Copyright Statement

Country of Publication:: United States

Language:: English

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