The genome of the naturally evolved obesity-prone Ossabaw miniature pig

Zhang, Yaolei; Fan, Guangyi; Liu, Xin; Skovgaard, Kerstin; Sturek, Michael; Heegaard, Peter M.H.

doi:10.1016/j.isci.2021.103081

Title: The genome of the naturally evolved obesity-prone Ossabaw miniature pig

Journal Article · 03 September 2021 · iScience

DOI: https://doi.org/10.1016/j.isci.2021.103081 · OSTI ID:2471786

^[1]; Fan, Guangyi ^[2];

^[2]; Skovgaard, Kerstin ^[3]; Sturek, Michael ^[4];

^[5]

Technical University of Denmark, Lyngby (Denmark); BGI-Qingdao (China); BGI-Shenzhen (China)
BGI-Qingdao (China); BGI-Shenzhen (China)
Technical University of Denmark, Lyngby (Denmark)
Indiana University School of Medicine, Indianapolis, IN (United States)
Technical University of Denmark, Lyngby (Denmark); University of Denmark, Lyngby (Denmark)

The feral pigs of Ossabaw Island (USA) have an outstanding propensity to obesity and develop complete metabolic syndrome (MetS) upon prolonged high energy dieting. We now report the first high quality genome of the Ossabaw pig with Contig N50 of ~6.03 Mb, significantly higher than most other published pig genomes. Genomic comparison to Duroc reveals that variations including SNPs, INDELs and one ~2 Mb inversion identified in Ossabaw pig may be related to its “thrifty” phenotype. Finally, an important positively selected gene (PSG) was found to be LEPR (leptin receptor) containing two positively selected sites which may lead to pseudogenization of this gene with possible significant effects on obesity and inflammation development. This work provides the first complete mapping of a genome representing a naturally ‘feast and famine’ evolved phenotype of MetS, serving as a blueprint to guide the search for new targets and new biomarkers for obesity comorbidities.

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Research Organization:: Savannah River Site (SRS), Aiken, SC (United States). Savannah River Ecology Laboratory (SREL)

Sponsoring Organization:: USDOE; U.S. National Institutes of Health Diabetes Research Center Swine Core

Grant/Contract Number:: EY-76-C-09-0819

OSTI ID:: 2471786

Journal Information:: iScience, Journal Name: iScience Journal Issue: 9 Vol. 24; ISSN 2589-0042

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
Animal Physiology
Genetics
Phylogenetics
Physiology
Science & Technology

Title: The genome of the naturally evolved obesity-prone Ossabaw miniature pig

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