Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies

Melchior, John T.; Swertfeger, Debi K.; Morris, Jamie; Street, Scott E.; Warshak, Carri R.; Welge, Jeffrey A.; Remaley, Alan T.; Catov, Janet M.; Davidson, W. Sean; Woollett, Laura A.

doi:10.1016/j.jlr.2021.100107

Title: Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies

Journal Article · 17 August 2021 · Journal of Lipid Research

DOI: https://doi.org/10.1016/j.jlr.2021.100107 · OSTI ID:2471576

^[1];

^[2]; Morris, Jamie ^[3]; Street, Scott E. ^[3]; Warshak, Carri R. ^[3]; Welge, Jeffrey A. ^[3]; Remaley, Alan T. ^[4]; Catov, Janet M. ^[5]; Davidson, W. Sean ^[3]; Woollett, Laura A. ^[3]

Univ. of Cincinnati, OH (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Children's Hospital Research Foundation, Cincinnati, OH (United States)
Univ. of Cincinnati, OH (United States)
National Institutes of Health (NIH), Bethesda, MD (United States)
Univ. of Pittsburgh, PA (United States)

Pregnancy is accompanied by significant physiological changes, which can impact the health and development of the fetus and mother. Pregnancy-induced changes in plasma lipoproteins are well documented, with modest to no impact observed on the generic measure of high density lipoprotein (HDL) cholesterol. However, the impact of pregnancy on the concentration and composition of HDL subspecies has not been examined in depth. In this prospective study, we collected plasma from 24 nonpregnant and 19 pregnant women in their second trimester. Using nuclear magnetic resonance (NMR), we quantified 11 different lipoprotein subspecies from plasma by size, including three in the HDL class. We observed an increase in the number of larger HDL particles in pregnant women, which were confirmed by tracking phospholipids across lipoproteins using high-resolution gel-filtration chromatography. Using liquid chromatography-mass spectrometry (LC-MS), we identified 87 lipid-associated proteins across size-speciated fractions. We report drastic shifts in multiple protein clusters across different HDL size fractions in pregnant females compared with nonpregnant controls that have major implications on HDL function. These findings significantly elevate our understanding of how changes in lipoprotein metabolism during pregnancy could impact the health of both the fetus and the mother.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2471576

Journal Information:: Journal of Lipid Research, Journal Name: Journal of Lipid Research Vol. 62; ISSN 0022-2275

Publisher:: American Society for Biochemistry and Molecular BiologyCopyright Statement

Country of Publication:: United States

Language:: English

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59 BASIC BIOLOGICAL SCIENCES
LC-MS
dyslipidemia
lipoprotein
lipoprotein metabolism
lipoprotein size
mass spectrometry
nuclear magnetic resonance spectroscopy
phospholipids
pregnancy
proteomics

Title: Pregnancy is accompanied by larger high density lipoprotein particles and compositionally distinct subspecies

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