Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns

Crane, Paul K.; Groot, Colin; Ossenkoppele, Rik; Mukherjee, Shubhabrata; Choi, Seo‐Eun; Lee, Michael; Scollard, Phoebe; Gibbons, Laura E.; Sanders, R. Elizabeth; Trittschuh, Emily; Saykin, Andrew J.; Mez, Jesse; Nakano, Connie; Donald, Christine Mac; Sohi, Harkirat; Risacher, Shannon

doi:10.1002/alz.13567

Title: Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns

Journal Article · 13 December 2023 · Alzheimer's & Dementia

DOI: https://doi.org/10.1002/alz.13567 · OSTI ID:2471548

Crane, Paul K. ^[1]; Groot, Colin ^[2]; Ossenkoppele, Rik ^[2]; Mukherjee, Shubhabrata ^[1]; Choi, Seo‐Eun ^[1]; Lee, Michael ^[1]; Scollard, Phoebe ^[1]; Gibbons, Laura E. ^[1]; Sanders, R. Elizabeth ^[1]; Trittschuh, Emily ^[3]; Saykin, Andrew J. ^[4]; Mez, Jesse ^[5];

^[1]; Donald, Christine Mac ^[1]; Sohi, Harkirat ^[6]; Risacher, Shannon ^[4]

Univ. of Washington, Seattle, WA (United States)
Lund Univ. (Sweden); Vrije Univ., Amsterdam (Netherlands). Medical Center (VUMC)
Univ. of Washington, Seattle, WA (United States); Veterans Affairs (VA) Puget Sound Health Care System, Seattle, WA (United States
Indiana University School of Medicine, Indianapolis IN (United States)
Boston Univ., MA (United States)
Univ. of Washington, Seattle, WA (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

We sought to determine structural magnetic resonance imaging (MRI) characteristics across subgroups defined based on relative cognitive domain impairments using data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to compare cognitively defined to imaging-defined subgroups. We used data from 584 people with Alzheimer's disease (AD) (461 amyloid positive, 123 unknown amyloid status) and 118 amyloid-negative controls. We used voxel-based morphometry to compare gray matter volume (GMV) for each group compared to controls and to AD-Memory. There was pronounced bilateral lower medial temporal lobe atrophy with relative cortical sparing for AD-Memory, lower left hemisphere GMV for AD-Language, anterior lower GMV for AD-Executive, and posterior lower GMV for AD-Visuospatial. Formal asymmetry comparisons showed substantially more asymmetry in the AD-Language group than any other group (p = 1.15 × 10^-10). For overlap between imaging-defined and cognitively defined subgroups, AD-Memory matched up with an imaging-defined limbic predominant group. MRI findings differ across cognitively defined AD subgroups.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Contributing Organization:: Alzheimer's Disease Neuroimaging Initiative

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2471548

Journal Information:: Alzheimer's & Dementia, Journal Name: Alzheimer's & Dementia Journal Issue: 3 Vol. 20; ISSN 1552-5260

Publisher:: WileyCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
Alzheimer's disease
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cognitive heterogeneity
dementia
neurodegeneration
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Title: Cognitively defined Alzheimer's dementia subgroups have distinct atrophy patterns

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