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Title: Improved accuracy of S-value-based dosimetry: a guide to transition from Cristy–Eckerman to ICRP adult phantoms

Journal Article · · EJNMMI Physics
ORCiD logo [1];  [1];  [2];  [3];  [4];  [2]
  1. Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), Baltimore, MD (United States)
  2. Radiopharmaceutical Imaging and Dosimetry, LLC (Rapid), Baltimore, MD (United States); Johns Hopkins Univ., Baltimore, MD (United States)
  3. Francis Marion University, Florence, SC (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
  4. Univ. of Florida, Gainesville, FL (United States)
+ Show Author Affiliations

Background: In 2016, the International Commission on Radiological Protection (ICRP) published the results of Monte Carlo simulations performed using updated and anatomically realistic voxelized phantoms. The resulting specific absorbed fractions are based on more realistic human anatomy than those computed in the stylized, geometrical Cristy–Eckerman (CE) phantom. Despite this development, the ICRP-absorbed fractions have not been widely adopted for radiopharmaceutical dosimetry. To help make the transition, we have established a correspondence between source and target tissues defined in the CE phantom and those defined in the ICRP phantoms. Results: The ICRP phantom has 79 source regions and 43 target regions in comparison with the 23 source and 18 target tissue regions defined in the CE phantom. The ICRP phantom provides tissue regions with greater anatomical detail. Some of this additional detail is focused on radiation protection and dosimetry of inhaled/ingested radioactivity. Some, but not all, of this detail is useful and appropriate for radiopharmaceutical therapy. We have established the correspondence between CE and ICRP phantom source and target regions and attempted to highlight the ICRP source tissues relevant to radiopharmaceutical therapy (RPT). This paper provides tables and figures highlighting the correspondences established. Conclusion: The results provide assistance in transitioning from CE-stylized phantoms to the anatomically accurate voxelized ICRP phantoms. It provides specific guidance for porting the total absorbed activity for regions as defined in the CE phantom to regions within the ICRP phantoms.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Engineering & Technology. Office of Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) Programs
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
2471437
Journal Information:
EJNMMI Physics, Journal Name: EJNMMI Physics Journal Issue: 1 Vol. 9; ISSN 2197-7364
Publisher:
BioMed CentralCopyright Statement
Country of Publication:
United States
Language:
English

References (5)

Basic anatomical and physiological data for use in radiological protection: reference values: ICRP Publication 89: Approved by the Commission in September 2001 journal September 2002
An image-based skeletal dosimetry model for the ICRP reference adult male—internal electron sources journal March 2011
ICRP Publication 133: The ICRP computational framework for internal dose assessment for reference adults: specific absorbed fractions journal November 2016
ICRP Publication 145: Adult Mesh-Type Reference Computational Phantoms journal October 2020
MIRD Pamphlet No. 21: A Generalized Schema for Radiopharmaceutical Dosimetry--Standardization of Nomenclature journal February 2009

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61 RADIATION PROTECTION AND DOSIMETRY
Cristy–Eckerman phantom
ICRP phantom
Radiopharmaceutical dosimetry