Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study

Rusiecki, Jennifer A.; McAdam, Jordan; Denic-Roberts, Hristina; Sjodin, Andreas; Davis, Mark; Jones, Richard; Hoang, Thanh D.; Ward, Mary H.; Ma, Shuangge; Zhang, Yawei

doi:10.1186/s12940-024-01068-0

Title: Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study

Journal Article · 19 March 2024 · Environmental Health

DOI: https://doi.org/10.1186/s12940-024-01068-0 · OSTI ID:2471286

Rusiecki, Jennifer A. ^[1]; McAdam, Jordan ^[2]; Denic-Roberts, Hristina ^[3]; Sjodin, Andreas ^[4]; Davis, Mark ^[4]; Jones, Richard ^[4]; Hoang, Thanh D. ^[1]; Ward, Mary H. ^[5]; Ma, Shuangge ^[6]; Zhang, Yawei ^[7]

Uniformed Services University of the Health Sciences, Bethesda, MD (United States)
Murtha Cancer Center Research Program, Bethesda, MD (United States); Henry M. Jackson Foundation for the Advancement of Military Medicine, Rockville, MD (United States)
Uniformed Services University of the Health Sciences, Bethesda, MD (United States); Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Centers for Disease Control and Prevention (CDC), Atlanta, GA (United States)
National Cancer Institute, Rockville, MD (United States)
Yale School of Public Health, New Haven, CT (United States)
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China); Yale School of Public Health, New Haven, CT (United States)

Background: The effects of organochlorine pesticide (OCP) exposure on the development of human papillary thyroid cancer (PTC) are not well understood. A nested case-control study was conducted with data from the U.S. Department of Defense Serum Repository (DoDSR) cohort between 2000 and 2013 to assess associations of individual OCPs serum concentrations with PTC risk. Methods: This study included 742 histologically confirmed PTC cases (341 females, 401 males) and 742 individually-matched controls with pre-diagnostic serum samples selected from the DoDSR. Associations between categories of lipid-corrected serum concentrations of seven OCPs and PTC risk were evaluated for classical PTC and follicular PTC using conditional logistic regression, adjusted for body mass index category and military branch to compute odds ratios (OR) and 95% confidence intervals (CIs). Effect modification by sex, birth cohort, and race was examined. Results: There was no evidence of associations between most of the OCPs and PTC, overall or stratified by histological subtype. Overall, there was no evidence of an association between hexachlorobenzene (HCB) and PTC, but stratified by histological subtype HCB was associated with significantly increased risk of classical PTC (third tertile above the limit of detection (LOD) vs.

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Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC); National Institutes of Health (NIH)

Grant/Contract Number:: SC0014664

OSTI ID:: 2471286

Journal Information:: Environmental Health, Journal Name: Environmental Health Journal Issue: 1 Vol. 23; ISSN 1476-069X

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Organochlorine pesticides and risk of papillary thyroid cancer in U.S. military personnel: a nested case-control study

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