Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

Feng, Su-Su; Wang, Si-Jing; Guo, Lin; Ma, Pan-Pan; Ye, Xiao-Long; Pan, Ming-Lin; Hang, Bo; Mao, Jian-Hua; Snijders, Antoine M.; Lu, Yi-Bing; Ding, Da-Fa

doi:10.4239/wjd.v15.i5.898

Title: Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

Journal Article · 14 May 2024 · World Journal of Diabetes

DOI: https://doi.org/10.4239/wjd.v15.i5.898 · OSTI ID:2470724

Feng, Su-Su ^[1]; Wang, Si-Jing ^[1]; Guo, Lin ^[1]; Ma, Pan-Pan ^[1]; Ye, Xiao-Long ^[1]; Pan, Ming-Lin ^[1]; Hang, Bo ^[2]; Mao, Jian-Hua ^[2]; Snijders, Antoine M. ^[2]; Lu, Yi-Bing ^[1]; Ding, Da-Fa ^[1]

Nanjing Medical University (China)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

The understanding of bile acid (BA) and unsaturated fatty acid (UFA) profiles, as well as their dysregulation, remains elusive in individuals with type 2 diabetes mellitus (T2DM) coexisting with non-alcoholic fatty liver disease (NAFLD). Investigating these metabolites could offer valuable insights into the pathophy-siology of NAFLD in T2DM. Our aim is to identify potential metabolite biomarkers capable of distinguishing between NAFLD and T2DM. A training model was developed involving 399 participants, comprising 113 healthy controls (HCs), 134 individuals with T2DM without NAFLD, and 152 individuals with T2DM and NAFLD. External validation encompassed 172 participants. NAFLD patients were divided based on liver fibrosis scores. The analytical approach employed univariate testing, orthogonal partial least squares-discriminant analysis, logistic regression, receiver operating characteristic curve analysis, and decision curve analysis to pinpoint and assess the diagnostic value of serum biomarkers. Compared to HCs, both T2DM and NAFLD groups exhibited diminished levels of specific BAs. In UFAs, particular acids exhibited a positive correlation with NAFLD risk in T2DM, while the ω-6:ω-3 UFA ratio demonstrated a negative correlation. Levels of α-linolenic acid and γ-linolenic acid were linked to significant liver fibrosis in NAFLD. The validation cohort substantiated the predictive efficacy of these biomarkers for assessing NAFLD risk in T2DM patients. This study underscores the connection between altered BA and UFA profiles and the presence of NAFLD in individuals with T2DM, proposing their potential as biomarkers in the pathogenesis of NAFLD.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470724

Journal Information:: World Journal of Diabetes, Journal Name: World Journal of Diabetes Journal Issue: 5 Vol. 15; ISSN 1948-9358

Publisher:: Baishideng Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
Bile acid
Non-alcoholic fatty liver disease
Type 2 diabetes mellitus
Unsaturated fatty acid

Title: Serum bile acid and unsaturated fatty acid profiles of non-alcoholic fatty liver disease in type 2 diabetic patients

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