The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China

Li, Xingguang; Li, Yanping; Liu, Haizhou; Trovão, Nídia S.; Foley, Brian T.

doi:10.1093/ve/veac014

Title: The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China

Journal Article · 16 February 2022 · Virus Evolution

DOI: https://doi.org/10.1093/ve/veac014 · OSTI ID:2470540

^[1]; Li, Yanping ^[2];

^[3]; Trovão, Nídia S. ^[4]; Foley, Brian T. ^[5]

Chinese Academy of Sciences (CAS), Ningbo (China)
Yuxi Normal Univ., Yuxi (China)
Chinese Academy of Sciences (CAS), Wuhan (China)
National Institutes of Health (NIH), Bethesda, MD (United States)
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States); Yuxi Normal Univ., Yuxi (China)

A total of 1155 partial pol gene sequences of human immunodeficiency virus (HIV)-1 CRF07_BC were sampled between 1997 and 2015, spanning 13 provinces in Mainland China and risk groups [heterosexual, injecting drug users (IDU), and men who have sex with men (MSM)] to investigate the evolution, adaptation, spatiotemporal and risk group dynamics, migration patterns, and protein structure of HIV-1 CRF07_BC. Due to the unequal distribution of sequences across time, location, and risk group in the complete dataset (‘full1155’), subsampling methods were used. Maximum-likelihood and Bayesian phylogenetic analysis as well as discrete trait analysis of geographical location and risk group were carried out. To study mutations of a cluster of HIV-1 CRF07_BC (CRF07-1), we performed a comparative analysis of this cluster to the other CRF07_BC sequences (‘backbone_295’) and mapped the mutations observed in the respective protein structure. Our findings showed that HIV-1 CRF07_BC most likely originated among IDU in Yunnan Province between October 1992 to July 1993 [95 per cent hightest posterior density (HPD): May 1989–August 1995] and that IDU in Yunnan Province and MSM in Guangdong Province likely served as the viral sources during the early and more recent spread in Mainland China. We also revealed that HIV-1 CRF07-1 has been spreading for roughly 20 years and continues to cause local transmission in Mainland China and worldwide. Overall, our study sheds light on the dynamics of HIV-1 CRF07_BC distribution patterns in Mainland China. Our research may also be useful in formulating public health policies aimed at controlling acquired immune deficiency syndrome in Mainland China and globally.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: National Key Research and Development Program of China; National Natural Science Foundation of China (NSFC); USDOE

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 2470540

Journal Information:: Virus Evolution, Journal Name: Virus Evolution Journal Issue: 1 Vol. 8; ISSN 2057-1577

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
CRF07-1
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Mainland China
phylogeography
spatiotemporal and risk group dynamics

Title: The emergence and transmission dynamics of HIV-1 CRF07_BC in Mainland China

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References (53)

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