HIResist: a database of HIV-1 resistance to broadly neutralizing antibodies

Misra, Milind; Jeffy, Jeffy; Liao, Charis; Pickthorn, Stephanie; Wagh, Kshitij; Herschhorn, Alon

doi:10.1093/bioinformatics/btae103

Title: HIResist: a database of HIV-1 resistance to broadly neutralizing antibodies

Journal Article · 28 February 2024 · Bioinformatics

DOI: https://doi.org/10.1093/bioinformatics/btae103 · OSTI ID:2470535

Misra, Milind ^[1]; Jeffy, Jeffy ^[1]; Liao, Charis ^[1]; Pickthorn, Stephanie ^[1]; Wagh, Kshitij ^[2];

^[1]

University of Minnesota, Minneapolis, MN (United States)
Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Changing the course of the human immunodeficiency virus type I (HIV-1) pandemic is a high public health priority with approximately 39 million people currently living with HIV-1 (PLWH) and about 1.5 million new infections annually worldwide. Broadly neutralizing antibodies (bnAbs) typically target highly conserved sites on the HIV-1 envelope glycoproteins (Envs), which mediate viral entry, and block the infection of diverse HIV-1 strains. But different mechanisms of HIV-1 resistance to bnAbs prevent robust application of bnAbs for therapeutic and preventive interventions. Here we report the development of a new database that provides data and computational tools to aid the discovery of resistant features and may assist in analysis of HIV-1 resistance to bnAbs. Bioinformatic tools allow identification of specific patterns in Env sequences of resistant strains and development of strategies to elucidate the mechanisms of HIV-1 escape; comparison of resistant and sensitive HIV-1 strains for each bnAb; identification of resistance and sensitivity signatures associated with specific bnAbs or groups of bnAbs; and visualization of antibody pairs on cross-sensitivity plots. The database has been designed with a particular focus on user-friendly and interactive interface. Our database is a valuable resource for the scientific community and provides opportunities to investigate patterns of HIV-1 resistance and to develop new approaches aimed to overcome HIV-1 resistance to bnAbs.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: 89233218CNA000001

OSTI ID:: 2470535

Journal Information:: Bioinformatics, Journal Name: Bioinformatics Journal Issue: 3 Vol. 40; ISSN 1367-4803

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United States

Language:: English

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Title: HIResist: a database of HIV-1 resistance to broadly neutralizing antibodies

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