Cysteine residues contribute to the regulation of Arabidopsis state transition 7 kinase

Ibrahim, Iskander M.; Lee, Ji H.; Weaver, Seth; Kwizera, Ronard; Lohman, Jeremy R.; Puthiyaveetil, Sujith

doi:10.1002/1873-3468.15032

Title: Cysteine residues contribute to the regulation of Arabidopsis state transition 7 kinase

Journal Article · 10 October 2024 · FEBS Letters

DOI: https://doi.org/10.1002/1873-3468.15032 · OSTI ID:2466312

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^[1]; Weaver, Seth ^[1];

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Department of Biochemistry and Center for Plant Biology Purdue University West Lafayette IN USA

State transitions are an acclimatory response by which plants, algae, and cyanobacteria counteract photosynthetic inefficiency caused by changes in incident light quality. In plants and green algae, state transition 7 (STN7/STT7) kinase promotes state 2 transition. Conserved cysteine residues are implicated in STN7/STT7 regulation, but the precise nature of their involvement remains unclear. Here, an analysis of the STN7 thiols in vitro and a determination of their midpoint redox potential indicate that the lumenal disulfide linkage is unlikely to be redox regulated while the stromal cysteines form a regulatory intramolecular disulfide. We further show that thioredoxin f 1 (Trx‐ f 1) reduces the STN7 stromal disulfide linkage as consistent with a Trx‐ f 1‐mediated inhibition of the kinase under high light.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0020639

OSTI ID:: 2466312

Journal Information:: FEBS Letters, Journal Name: FEBS Letters Journal Issue: 3 Vol. 599; ISSN 0014-5793

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Netherlands

Language:: English

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