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Title: Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products

Journal Article · · Gut Microbes
ORCiD logo [1]; ORCiD logo [1]; ORCiD logo [1];  [2]; ORCiD logo [3]; ORCiD logo [4]; ORCiD logo [3]
  1. Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul, Korea
  2. Microbiology and Functionality Research Group, World Institute of Kimchi, Gwangju, Korea
  3. Department of Life and Nanopharmaceutical Sciences and Department of Biology, Kyung Hee University, Seoul, Korea, Department of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, Korea
  4. Department of Life Science, Chung-Ang University, Seoul, Korea

Not Available

Sponsoring Organization:
USDOE EM Office of Technology Innovation and Development (EM-30)
OSTI ID:
2460581
Journal Information:
Gut Microbes, Journal Name: Gut Microbes Journal Issue: 1 Vol. 16; ISSN 1949-0976
Publisher:
Informa UK LimitedCopyright Statement
Country of Publication:
United States
Language:
English

References (176)

Frozen vs Fresh Fecal Microbiota Transplantation and Clinical Resolution of Diarrhea in Patients With RecurrentClostridium difficileInfection journal January 2016
Effect of Fecal Microbiota Transplantation on 8-Week Remission in Patients With Ulcerative Colitis journal January 2019
Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics journal August 2018
Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection journal February 2023
Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis journal August 2020
Fecal microbiota transplantation for rheumatoid arthritis: A case report journal December 2020
Biomarkers for immune checkpoint inhibition in non–small cell lung cancer (NSCLC) journal November 2019
Fecal microbiota transplant from a rational stool donor improves hepatic encephalopathy: A randomized clinical trial journal October 2017
Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial journal June 2019
Mechanisms and consequences of intestinal dysbiosis journal March 2017
Healthy Human Gastrointestinal Microbiome: Composition and Function After a Decade of Exploration journal February 2020
Fecal microbiota transplantation compared with prednisolone in severe alcoholic hepatitis patients: a randomized trial journal December 2022
Corticosteroids, nutrition, pentoxifylline, or fecal microbiota transplantation for severe alcoholic hepatitis journal May 2018
The gut microbiome in neurological disorders journal February 2020
Cells of the innate and adaptive immunity and their interactions in inflammatory bowel disease journal March 2017
Restoration of short chain fatty acid and bile acid metabolism following fecal microbiota transplantation in patients with recurrent Clostridium difficile infection journal October 2018
The role of short-chain fatty acids in Clostridioides difficile infection: A review journal June 2022
Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson’s disease via gut microbiota-GLP-1 pathway journal January 2021
The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism journal November 2022
The links between gut microbiota and obesity and obesity related diseases journal March 2022
Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease journal January 2015
Effects of Fecal Microbiota Transplantation With Oral Capsules in Obese Patients journal April 2020
Salmonella Manipulation of Host Signaling Pathways Provokes Cellular Transformation Associated with Gallbladder Carcinoma journal June 2015
Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids journal April 2018
Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors journal October 2021
Colonization of the live biotherapeutic product VE303 and modulation of the microbiota and metabolites in healthy volunteers journal April 2022
Dysfunctional Families: Clostridium scindens and Secondary Bile Acids Inhibit the Growth of Clostridium difficile journal January 2015
Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease journal May 2017
Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition journal October 2017
A Universal Gut-Microbiome-Derived Signature Predicts Cirrhosis journal November 2020
European Society of Clinical Microbiology and Infectious Diseases: 2021 update on the treatment guidance document for Clostridioides difficile infection in adults journal December 2021
Faecal microbiota transplantation in recurrent Clostridium difficile infection: Recommendations from the French Group of Faecal microbiota Transplantation journal March 2016
Selección del donante para la transferencia de microbiota fecal. Documento de posicionamiento de la Societat Catalana de Digestologia y de la Societat Catalana de Malalties Infeccioses i Microbiologia Clínica journal February 2021
Mo1667 FECAL MICROBIOTA TRANSPLANTATION FOR CHILDREN WITH AUTISM SPECTRUM DISORDER journal June 2019
Fecal Microbiota Transplantation journal March 2017
Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production journal April 2016
Safety and efficacy of fecal microbiota transplantation for treatment of systemic lupus erythematosus: An EXPLORER trial journal June 2022
Protective effect of probiotic Limosilactobacillus reuteri DSM17938 against western diet-induced obesity and associated metabolic alterations journal October 2023
Faecal microbiota transplantation for the decolonization of antibiotic-resistant bacteria in the gut: a systematic review and meta-analysis journal June 2019
Microbiota-gut-brain signalling in Parkinson's disease: Implications for non-motor symptoms journal June 2016
Discovery and delivery strategies for engineered live biotherapeutic products journal March 2022
Clostridioides difficile journal December 2018
Multi-omic analyses identify mucosa bacteria and fecal metabolites associated with weight loss after fecal microbiota transplantation journal September 2022
Successful Resolution of Recurrent Clostridium difficile Infection using Freeze-Dried, Encapsulated Fecal Microbiota; Pragmatic Cohort Study journal June 2017
Obesity-associated gut microbiota is enriched in Lactobacillus reuteri and depleted in Bifidobacterium animalis and Methanobrevibacter smithii journal August 2011
An obesity-associated gut microbiome with increased capacity for energy harvest journal December 2006
The Human Microbiome Project journal October 2007
A human gut microbial gene catalogue established by metagenomic sequencing journal March 2010
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity journal February 2012
Human gut microbiome viewed across age and geography journal May 2012
A metagenome-wide association study of gut microbiota in type 2 diabetes journal September 2012
Diversity, stability and resilience of the human gut microbiota journal September 2012
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota journal July 2013
Medicines from microbiota journal April 2013
Development of a synthetic live bacterial therapeutic for the human metabolic disease phenylketonuria journal October 2018
Dysbiosis and the immune system journal March 2017
Microbiota in health and diseases journal April 2022
Effect of fecal microbiota transplantation route of administration on gut colonization and host response in preterm pigs journal October 2018
Fecal microbiota transplantation for the treatment of steroid-refractory, intestinal, graft-versus-host disease in a pediatric patient journal July 2022
Precise quantification of bacterial strains after fecal microbiota transplantation delineates long-term engraftment and explains outcomes journal September 2021
Towards a deeper understanding of the vaginal microbiota journal March 2022
The gut microbiota influences anticancer immunosurveillance and general health journal April 2018
Adverse effects of immune-checkpoint inhibitors: epidemiology, management and surveillance journal May 2019
Gut microbiota in human metabolic health and disease journal September 2020
Bile acids and the gut microbiota: metabolic interactions and impacts on disease journal October 2022
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases journal February 2019
The microbiome, cancer, and cancer therapy journal March 2019
Vaginal microbiome transplantation in women with intractable bacterial vaginosis journal October 2019
Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial journal July 2021
Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial journal February 2022
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases journal September 2022
Total fecal microbiota transplantation alleviates high-fat diet-induced steatohepatitis in mice via beneficial regulation of gut microbiota journal May 2017
A taxonomic signature of obesity in a large study of American adults journal June 2018
Effect of 8 week intake of probiotic milk products on risk factors for cardiovascular diseases journal March 2000
Findings From a Randomized Controlled Trial of Fecal Transplantation for Patients With Ulcerative Colitis journal July 2015
Pathobiology of Helicobacter pylori–Induced Gastric Cancer journal January 2016
Alterations in Enteric Virome Are Associated With Colorectal Cancer and Survival Outcomes journal August 2018
Nonalcoholic Fatty Liver Disease: Modulating Gut Microbiota to Improve Severity? journal May 2020
Gut Microbiota Modulation of Efficacy and Toxicity of Cancer Chemotherapy and Immunotherapy journal February 2023
Burden of Clostridium difficile Infection in the United States journal February 2015
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant journal November 2019
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice journal January 2007
Vaginal microbiome of reproductive-age women journal June 2010
Lactiplantibacillus plantarum as a promising adjuvant for neurological disorders therapy through the brain-gut axis and related action pathways journal November 2023
Current research progress, opportunities, and challenges of Limosillactobacillus reuteri -based probiotic dietary strategies journal June 2024
Engineered probiotics as live biotherapeutics for diagnosis and treatment of human diseases journal March 2023
Targeting toll-like receptor 4 to modulate neuroinflammation in central nervous system disorders journal October 2019
A profile of the live biotherapeutic product RBX2660 and its role in preventing recurrent Clostridioides difficile infection journal February 2023
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism journal March 2016
Challenges in fecal donor selection and screening for fecal microbiota transplantation: A review journal January 2017
Microbiota Insights in Clostridium Difficile Infection and Inflammatory Bowel Disease journal March 2020
Effect of antibiotic pretreatment on bacterial engraftment after Fecal Microbiota Transplant (FMT) in IBS-D journal January 2022
Species- and strain-level assessment using rrn long-amplicons suggests donor’s influence on gut microbial transference via fecal transplants in metabolic syndrome subjects journal May 2022
Emerging issues in probiotic safety: 2023 perspectives journal March 2023
Role of Faecal Microbiota Transplantation for Maintenance of Remission in Patients With Ulcerative Colitis: A Pilot Study journal March 2019
Combined Oral Fecal Capsules Plus Fecal Enema as Treatment of Late-Onset Autism Spectrum Disorder in Children: Report of a Small Case Series journal October 2016
Development of synthetic biotics as treatment for human diseases journal January 2022
Facing a new challenge journal May 2019
Fecal microbiota transplantation to treat Parkinson's disease with constipation journal June 2019
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma journal October 2011
Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment journal March 2020
Efficacy of faecal microbiota transplantation in Crohn’s disease: a new target treatment? journal January 2020
Quality of probiotic products for preterm infants: Contamination and missing strains journal September 2019
Recurrent Clostridium difficile infection associates with distinct bile acid and microbiome profiles journal April 2016
Review article: the future of microbiome‐based therapeutics journal May 2022
The intestinal microbiota: Antibiotics, colonization resistance, and enteric pathogens journal August 2017
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species journal December 2010
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice journal September 2013
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10 journal August 2000
Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients journal November 2017
The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies journal March 2018
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients journal February 2021
Fecal microbiota transplant overcomes resistance to anti–PD-1 therapy in melanoma patients journal February 2021
Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target journal August 2023
Temporal Dynamics of the Human Vaginal Microbiota journal May 2012
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome journal December 2018
Antibiotic Usage and Risk of Colonization and Infection with Antibiotic-Resistant Bacteria: a Hospital Population-Based Study journal October 2009
The First Microbial Colonizers of the Human Gut: Composition, Activities, and Health Implications of the Infant Gut Microbiota journal December 2017
An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice journal June 2013
Bacteriophage transfer during faecal microbiota transplantation inClostridium difficileinfection is associated with treatment outcome journal May 2017
The use of faecal microbiota transplant as treatment for recurrent or refractoryClostridium difficileinfection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines journal August 2018
Transfer of a healthy microbiota reduces amyloid and tau pathology in an Alzheimer’s disease animal model journal August 2019
Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study journal December 2019
Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model journal March 2020
Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial journal October 2020
Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial journal March 2021
Gut microbiota regulate Alzheimer’s disease pathologies and cognitive disorders via PUFA-associated neuroinflammation journal January 2022
Revisiting the donor screening protocol of faecal microbiota transplantation (FMT): a systematic review journal May 2023
The Microbiota-Gut-Brain Axis journal October 2019
The Effect of Fecal Microbiota Transplantation on a Child with Tourette Syndrome journal January 2017
Colonization of the Human Gut by E. coli and Colorectal Cancer Risk journal February 2014
Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma journal February 2021
The role of the gut microbiome in colonization resistance and recurrent Clostridioides difficile infection journal January 2022
Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial journal April 2022
Changes in microbiota composition, bile and fatty acid metabolism, in successful faecal microbiota transplantation for Clostridioides difficile infection journal August 2018
The association between fecal enterotoxigenic B. fragilis with colorectal cancer journal September 2019
Radiotherapy and the gut microbiome: facts and fiction journal January 2021
Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease journal March 2022
Fecal microbiota transplantation combined with ruxolitinib as a salvage treatment for intestinal steroid-refractory acute GVHD journal November 2022
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study journal January 2017
Fecal microbiota transplantation to maintain remission in Crohn’s disease: a pilot randomized controlled study journal February 2020
Synthetic bacterial consortia transplantation for the treatment of Gardnerella vaginalis-induced bacterial vaginosis in mice journal March 2023
Fecal microbiota transplantation associated with 10 years of stability in a patient with SPMS journal July 2018
Healthy Donor Fecal Microbiota Transplantation for Recurrent Bacterial Cholangitis in Primary Sclerosing Cholangitis – A Single Case Report journal August 2018
Fecal Microbiota Transplantation in Patients With Primary Sclerosing Cholangitis: A Pilot Clinical Trial journal January 2019
A Double-Blind, Placebo-Controlled Trial to Assess Safety and Tolerability of (Thetanix) Bacteroides thetaiotaomicron in Adolescent Crohn's Disease journal January 2021
Serendipity in Refractory Celiac Disease: Full Recovery of Duodenal Villi and Clinical Symptoms after Fecal Microbiota Transfer journal September 2016
Clinical and immune effects of fecal microbiota transplantation in children with acute graft-versus-host disease journal April 2021
Presence of Salmonella AvrA in colorectal tumor and its precursor lesions in mouse intestine and human specimens journal July 2017
Treating Clostridioides difficile: Could Microbiota-based Live Biotherapeutic Products Provide the Answer? journal May 2023
A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease journal April 2019
Commensal Obligate Anaerobic Bacteria and Health: Production, Storage, and Delivery Strategies journal June 2020
Microbiome engineering: engineered live biotherapeutic products for treating human disease journal September 2022
Fecal Microbiota Transplantation Relieves Gastrointestinal and Autism Symptoms by Improving the Gut Microbiota in an Open-Label Study journal October 2021
Effect of Fecal Microbiota Transplantation on Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial journal July 2022
Prospective Study Reveals Host Microbial Determinants of Clinical Response to Fecal Microbiota Transplant Therapy in Type 2 Diabetes Patients journal March 2022
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases journal March 2019
Safety and Efficacy of Fecal Microbiota Transplantation for Grade IV Steroid Refractory GI-GvHD Patients: Interim Results From FMT2017002 Trial journal June 2021
Live Biotherapeutic Products, A Road Map for Safety Assessment journal June 2020
Fresh Versus Frozen Stool for Fecal Microbiota Transplantation—Assessment by Multimethod Approach Combining Culturing, Flow Cytometry, and Next-Generation Sequencing journal July 2022
In vitro Characterization of Gut Microbiota-Derived Bacterial Strains With Neuroprotective Properties journal September 2019
Single-Arm, Non-randomized, Time Series, Single-Subject Study of Fecal Microbiota Transplantation in Multiple Sclerosis journal September 2020
Microbiota-Derived Metabolites in Tumor Progression and Metastasis journal August 2020
Fecal Microbiota Transplant in a Pre-Clinical Model of Type 2 Diabetes Mellitus, Obesity and Diabetic Kidney Disease journal March 2022
Amelioration of Maternal Immune Activation-Induced Autism Relevant Behaviors by Gut Commensal Parabacteroides goldsteinii journal October 2022
Repeated Fecal Microbial Transplantations and Antibiotic Pre-Treatment Are Linked to Improved Clinical Response and Remission in Inflammatory Bowel Disease: A Systematic Review and Pooled Proportion Meta-Analysis journal March 2021
Fecal Microbiota Transplantation as New Therapeutic Avenue for Human Diseases journal July 2022
Probiotic Supplementation in a Clostridium difficile-Infected Gastrointestinal Model Is Associated with Restoring Metabolic Function of Microbiota journal December 2019
Bile Acid–Gut Microbiota Axis in Inflammatory Bowel Disease: From Bench to Bedside journal September 2021
Listeria monocytogenes as a Vector for Cancer Immunotherapy: Current Understanding and Progress journal July 2018
Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update journal January 2016
Fecal microbiota transplantation cured epilepsy in a case with Crohn’s disease: The first report journal January 2017
Dysbiosis and liver diseases (Review) journal July 2021
Therapeutic Potential of Escherichia coli Nissle 1917 in Clinically Remission-attained Ulcerative Colitis Patients: A Hospital-based Cohort Study journal January 2021
Parkinson’s Disease: The Emerging Role of Gut Dysbiosis, Antibiotics, Probiotics, and Fecal Microbiota Transplantation journal July 2019
Clinical Practice Guidelines for Fecal Microbiota Transplantation in Korea journal January 2022