Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

Qi, Yalin; Han, Hesong; Liu, Albert; Zhao, Sheng; Lawanprasert, Atip; Nielsen, Josefine Eilsø; Choudhary, Hema; Liang, Dengpan; Barron, Annelise E.; Murthy, Niren

doi:10.1039/D4RA05007J

Title: Ethylene oxide graft copolymers reduce the immunogenicity of lipid nanoparticles

Journal Article · 18 September 2024 · RSC Advances

DOI: https://doi.org/10.1039/D4RA05007J · OSTI ID:2447540

^[1];

^[1]; Liu, Albert ^[1]; Zhao, Sheng ^[1]; Lawanprasert, Atip ^[1]; Nielsen, Josefine Eilsø ^[2]; Choudhary, Hema ^[1]; Liang, Dengpan ^[1];

^[3];

^[1]

Department of Bioengineering, University of California, Berkeley, Berkeley, California 94720, USA, Innovative Genomics Institute (IGI), Berkeley, California 94704, USA
Department of Bioengineering, School of Medicine, Stanford University, Stanford, California 94305, USA, Department of Science and Environment, Roskilde University, Roskilde 4000, Denmark
Department of Bioengineering, School of Medicine, Stanford University, Stanford, California 94305, USA

LNPs made with the polyamide PGE have low immunogenicity and outperform PEG-LNPs after chronic administration.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 2447540

Journal Information:: RSC Advances, Journal Name: RSC Advances Journal Issue: 41 Vol. 14; ISSN 2046-2069; ISSN RSCACL

Publisher:: Royal Society of Chemistry (RSC)Copyright Statement

Country of Publication:: United Kingdom

Language:: English

References (18)

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