Computationally Driven Discovery of a BCR-ABL1 Kinase Inhibitor with Activity in Multidrug-Resistant Chronic Myeloid Leukemia

Hill, Jarvis; Givhan, R. Houston; Yi, Bin; Jones, Robert M.; Douglass, Eugene F.; Xi, Yaguang; Schaefer, III, Henry F.; Crich, David

doi:10.1021/acs.jmedchem.4c01852

Title: Computationally Driven Discovery of a BCR-ABL1 Kinase Inhibitor with Activity in Multidrug-Resistant Chronic Myeloid Leukemia

Journal Article · 23 September 2024 · Journal of Medicinal Chemistry

DOI: https://doi.org/10.1021/acs.jmedchem.4c01852 · OSTI ID:2447489

^[1]; Givhan, R. Houston ^[2]; Yi, Bin ^[3]; Jones, Robert M. ^[4]; Douglass, Eugene F. ^[3]; Xi, Yaguang ^[3];

^[2];

^[5]

Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States, Department of Chemistry, University of Georgia, 302 East Campus Road, Athens, Georgia 30602, United States
Department of Chemistry, University of Georgia, 302 East Campus Road, Athens, Georgia 30602, United States, Center for Computational Quantum Chemistry, University of Georgia, 1004 Cedar Street, Athens, Georgia 30602, United States
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States
Independent consultant, P.O. Box 568, Oakley, Utah 84055-0568, United States
Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States, Department of Chemistry, University of Georgia, 302 East Campus Road, Athens, Georgia 30602, United States, Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, United States

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Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0018412

OSTI ID:: 2447489

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 19 Vol. 67; ISSN 0022-2623

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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