Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

Many, Gina M.; Sanford, James A.; Sagendorf, Tyler J.; Hou, Zhenxin; Nigro, Pasquale; Whytock, Katie L.; Amar, David; Caputo, Tiziana; Gay, Nicole R.; Gaul, David A.; Hirshman, Michael F.; Jimenez-Morales, David; Lindholm, Malene E.; Muehlbauer, Michael J.; Vamvini, Maria; Bergman, Bryan C.; Fernández, Facundo M.; Goodyear, Laurie J.; Hevener, Andrea L.; Ortlund, Eric A.; Sparks, Lauren M.; Xia, Ashley; Adkins, Joshua N.; Bodine, Sue C.; Newgard, Christopher B.; Schenk, Simon; Armenteros, Jose Almagro; Amper, Mary S.; Ashley, Euan; Asokan, Aneesh Kumar; Avila-Pacheco, Julian; Bae, Dam; Bamman, Marcas M.; Bararpour, Nasim; Barnes, Jerry; Buford, Thomas W.; Burant, Charles F.; Carbone, Nicholas P.; Carr, Steven A.; Chambers, Toby L.; Chavez, Clarisa; Chiu, Roxanne; Clish, Clary B.; Cutter, Gary R.; Dasari, Surendra; Dennis, Courtney; Evans, Charles R.; Fernandez, Facundo M.; Gagne, Nicole; Ge, Yongchao; Goodpaster, Bret H.; Gritsenko, Marina A.; Hansen, Joshua R.; Hennig, Krista M.; Huffman, Kim M.; Hung, Chia-Jui; Hutchinson-Bunch, Chelsea; Ilkayeva, Olga; Ivanova, Anna A.; Beltran, Pierre Jean; Jin, Christopher A.; Kachman, Maureen T.; Keshishian, Hasmik; Kraus, William E.; Lanza, Ian; Lester, Bridget; Li, Jun Z.; Lira, Ana K.; Liu, Xueyun; Maner-Smith, Kristal M.; May, Sandy; Monroe, Matthew R.; Montgomery, Stephen; Moore, Ronald J.; Moore, Samuel G.; Nachun, Daniel; Nair, K. Sreekumaran; Nair, Venugopalan; Raja, Archana Natarajan; Nestor, Michael D.; Nudelman, German; Petyuk, Vladislav A.; Piehowski, Paul D.; Pincas, Hanna; Qian, Wei-Jun; Raskind, Alexander; Rasmussen, Blake B.; Rooney, Jessica L.; Rushing, Scott; Samdarshi, Mihir; Sealfon, Stuart C.; Smith, Kevin S.; Smith, Gregory R.; Snyder, Michael; Stowe, Cynthia L.; Talton, Jennifer W.; Teng, Christopher; Thalacker-Mercer, Anna; Tracy, Russell; Trappe, Todd A.; Vasoya, Mital; Vetr, Nikolai G.; Volpi, Elena; Walkup, Michael P.; Walsh, Martin J.; Wheeler, Matthew T.; Wu, Si; Zaslavsky, Elena; Zebarjadi, Navid; Zhang, Tiantian; Zhao, Bingqing; Zhen, Jimmy

doi:10.1038/s42255-023-00959-9

Title: Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

Journal Article · 01 May 2024 · Nature Metabolism

DOI: https://doi.org/10.1038/s42255-023-00959-9 · OSTI ID:2446702

;

; Muehlbauer, Michael J.;

;

Subcutaneous white adipose tissue (scWAT) is a dynamic storage and secretory organ that regulates systemic homeostasis, yet the impact of endurance exercise training (ExT) and sex on its molecular landscape is not fully established. Utilizing an integrative multi-omics approach, and leveraging data generated by the Molecular Transducers of Physical Activity Consortium (MoTrPAC), we show profound sexual dimorphism in the scWAT of sedentary rats and in the dynamic response of this tissue to ExT. Specifically, the scWAT of sedentary females displays -omic signatures related to insulin signaling and adipogenesis, whereas the scWAT of sedentary males is enriched in terms related to aerobic metabolism. These sex-specific -omic signatures are preserved or amplified with ExT. Integration of multi-omic analyses with phenotypic measures identifies molecular hubs predicted to drive sexually distinct responses to training. Overall, this study underscores the powerful impact of sex on adipose tissue biology and provides a rich resource to investigate the scWAT response to ExT.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Contributing Organization:: MoTrPAC Study Group

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2446702

Report Number(s):: PNNL-SA--181714

Journal Information:: Nature Metabolism, Journal Name: Nature Metabolism Journal Issue: 5 Vol. 6; ISSN 2522-5812

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

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