Structure–activity relationship study of small-molecule inhibitor of Atg12-Atg3 protein–protein interaction

Skach, Krystof; Boserle, Jiri; Nuta, Gal Chaim; Břehová, Petra; Bialik, Shani; Carvalho, Silvia; Kozer, Noga; Barr, Haim; Chaloupecká, Ema; Kimchi, Adi; Nencka, Radim

doi:10.1016/j.bmcl.2024.129939

Title: Structure–activity relationship study of small-molecule inhibitor of Atg12-Atg3 protein–protein interaction

Journal Article · 01 November 2024 · Bioorganic and Medicinal Chemistry Letters

DOI: https://doi.org/10.1016/j.bmcl.2024.129939 · OSTI ID:2440127

;

; Nuta, Gal Chaim;

; Bialik, Shani; Carvalho, Silvia; Kozer, Noga;

; Chaloupecká, Ema; Kimchi, Adi;

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

OSTI ID:: 2440127

Journal Information:: Bioorganic and Medicinal Chemistry Letters, Journal Name: Bioorganic and Medicinal Chemistry Letters Journal Issue: C Vol. 112; ISSN 0960-894X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Discovery and SAR of 5-(3-Chlorophenylamino)benzo[ c ][2,6]naphthyridine-8-carboxylic Acid (CX-4945), the First Clinical Stage Inhibitor of Protein Kinase CK2 for the Treatment of Cancer Pierre, Fabrice; Chua, Peter C.; O’Brien, Sean E. Journal of Medicinal Chemistry, Vol. 54, Issue 2 https://doi.org/10.1021/jm101251q	journal	January 2011
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment Sui, X.; Chen, R.; Wang, Z. Cell Death & Disease, Vol. 4, Issue 10 https://doi.org/10.1038/cddis.2013.350	journal	October 2013
Deconvoluting the context-dependent role for autophagy in cancer White, Eileen Nature Reviews Cancer, Vol. 12, Issue 6 https://doi.org/10.1038/nrc3262	journal	April 2012
Autophagy: molecular machinery for self-eating Yorimitsu, T.; Klionsky, D. J. Cell Death & Differentiation, Vol. 12, Issue S2 https://doi.org/10.1038/sj.cdd.4401765	journal	October 2005
Autophagy-dependent secretion: mechanism, factors secreted, and disease implications New, Jacob; Thomas, Sufi Mary Autophagy, Vol. 15, Issue 10, p. 1682-1693 https://doi.org/10.1080/15548627.2019.1596479	journal	April 2019
Hierarchy of Atg proteins in pre-autophagosomal structure organization Suzuki, Kuninori; Kubota, Yuka; Sekito, Takayuki Genes to Cells, Vol. 12, Issue 2 https://doi.org/10.1111/j.1365-2443.2007.01050.x	journal	February 2007
Does Chloroquine, an Antimalarial Drug, Affect Autophagy in Tetrahymena pyriformis? Nilsson, Jytte R. The Journal of Protozoology, Vol. 39, Issue 1 https://doi.org/10.1111/j.1550-7408.1992.tb01278.x	journal	January 1992
Autophagy as a Regulated Pathway of Cellular Degradation Klionsky, D. J. Science, Vol. 290, Issue 5497 https://doi.org/10.1126/science.290.5497.1717	journal	December 2000
Autophagy in the Eukaryotic Cell Reggiori, Fulvio; Klionsky, Daniel J. Eukaryotic Cell, Vol. 1, Issue 1 https://doi.org/10.1128/EC.01.1.11-21.2002	journal	February 2002
Apoptosis, autophagy, necroptosis, and cancer metastasis Su, Zhenyi; Yang, Zuozhang; Xu, Yongqing Molecular Cancer, Vol. 14, Issue 1 https://doi.org/10.1186/s12943-015-0321-5	journal	February 2015
Autophagy and IL-1 Family Cytokines Harris, James Frontiers in Immunology, Vol. 4 https://doi.org/10.3389/fimmu.2013.00083	journal	January 2013

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