Lysophosphatidic Acid Signaling in the Gastrointestinal System

Yun, C. Chris; Han, Yiran; McConnell, Beth

doi:10.1016/j.jcmgh.2024.101398

Title: Lysophosphatidic Acid Signaling in the Gastrointestinal System

Journal Article · 01 January 2024 · Cellular and Molecular Gastroenterology and Hepatology

DOI: https://doi.org/10.1016/j.jcmgh.2024.101398 · OSTI ID:2439321

; Han, Yiran; McConnell, Beth

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Sponsoring Organization:: USDOE

OSTI ID:: 2439321

Journal Information:: Cellular and Molecular Gastroenterology and Hepatology, Journal Name: Cellular and Molecular Gastroenterology and Hepatology Journal Issue: 6 Vol. 18; ISSN 2352-345X

Publisher:: ElsevierCopyright Statement

Country of Publication:: Netherlands

Language:: English

References (107)

Ziritaxestat, a Novel Autotaxin Inhibitor, and Lung Function in Idiopathic Pulmonary Fibrosis Maher, Toby M.; Ford, Paul; Brown, Kevin K. JAMA, Vol. 329, Issue 18 https://doi.org/10.1001/jama.2023.5355	journal	May 2023
Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization Jin, Yixin; Knudsen, Eirunn; Wang, Ling European Journal of Immunology, Vol. 33, Issue 8 https://doi.org/10.1002/eji.200323711	journal	June 2003
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions Kremer, Andreas E.; van Dijk, Remco; Leckie, Pamela Hepatology, Vol. 56, Issue 4 https://doi.org/10.1002/hep.25748	journal	October 2012
Hepatocyte autotaxin expression promotes liver fibrosis and cancer Kaffe, Eleanna; Katsifa, Aggeliki; Xylourgidis, Nikos Hepatology, Vol. 65, Issue 4 https://doi.org/10.1002/hep.28973	journal	February 2017
Dysregulation of the Lysophosphatidylcholine/Autotaxin/Lysophosphatidic Acid Axis in Acute‐on‐Chronic Liver Failure Is Associated With Mortality and Systemic Inflammation by Lysophosphatidic Acid–Dependent Monocyte Activation Trovato, Francesca M.; Zia, Rabiya; Napoli, Salvatore Hepatology, Vol. 74, Issue 2 https://doi.org/10.1002/hep.31738	journal	June 2021
Submucosal connective tissue-type mast cells contribute to the production of lysophosphatidic acid (LPA) in the gastrointestinal tract through the secretion of autotaxin (ATX)/lysophospholipase D (lysoPLD) Mori, Ken; Kitayama, Joji; Aoki, Junken Virchows Archiv, Vol. 451, Issue 1 https://doi.org/10.1007/s00428-007-0425-4	journal	June 2007
Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells Shin, Kum-Joo; Kim, You Lim; Lee, Sukmook Journal of Cancer Research and Clinical Oncology, Vol. 135, Issue 1 https://doi.org/10.1007/s00432-008-0441-z	journal	July 2008
Autotaxin and LPA receptor signaling in cancer Houben, Anna J. S.; Moolenaar, Wouter H. Cancer and Metastasis Reviews, Vol. 30, Issue 3-4 https://doi.org/10.1007/s10555-011-9319-7	journal	October 2011
Intragastrically Administered Lysophosphatidic Acids Protect Against Gastric Ulcer in Rats Under Water-Immersion Restraint Stress Adachi, Mika; Horiuchi, Gou; Ikematsu, Natsuki Digestive Diseases and Sciences, Vol. 56, Issue 8 https://doi.org/10.1007/s10620-011-1595-0	journal	February 2011
Daily Intake of High-Fat Diet with Lysophosphatidic Acid-Rich Soybean Phospholipids Augments Colon Tumorigenesis in Kyoto Apc Delta Rats Tsutsumi, Toshihiko; Inoue, Manami; Okamoto, Yoko Digestive Diseases and Sciences, Vol. 62, Issue 3 https://doi.org/10.1007/s10620-016-4434-5	journal	January 2017
Immunohistochemical Detection of Autotaxin (ATX)/Lysophospholipase D (lysoPLD) in Submucosal Invasive Colorectal Cancer Kazama, Shinsuke; Kitayama, Joji; Aoki, Junken Journal of Gastrointestinal Cancer, Vol. 42, Issue 4 https://doi.org/10.1007/s12029-010-9186-4	journal	July 2010
Lysophosphatidic acid induces both EGFR-dependent and EGFR-independent effects on DNA synthesis and migration in pancreatic and colorectal carcinoma cells Tveteraas, Ingun Heiene; Aasrum, Monica; Brusevold, Ingvild Johnsen Tumor Biology, Vol. 37, Issue 2 https://doi.org/10.1007/s13277-015-4010-1	journal	September 2015
Pharmacologically active acidic phospholipids and glycolipids Vogt, W. Biochemical Pharmacology, Vol. 12, Issue 4 https://doi.org/10.1016/0006-2952(63)90074-1	journal	April 1963
Lysophosphatidic acid synthesis and release Pagès, Céline; Simon, Marie-Françoise; Valet, Philippe Prostaglandins & Other Lipid Mediators, Vol. 64, Issue 1-4 https://doi.org/10.1016/S0090-6980(01)00110-1	journal	April 2001
Homo- and hetero-dimerization of LPA/S1P receptors, OGR1 and GPR4 Zaslavsky, Alexander; Singh, Lisam Shanjukumar; Tan, Haiyan Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1761, Issue 10 https://doi.org/10.1016/j.bbalip.2006.08.011	journal	October 2006
Phosphatase-resistant analogues of lysophosphatidic acid: Agonists promote healing, antagonists and autotaxin inhibitors treat cancer Prestwich, G. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1781, Issue 9 https://doi.org/10.1016/j.bbalip.2008.03.008	journal	September 2008
Two pathways for lysophosphatidic acid production Aoki, J. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1781, Issue 9 https://doi.org/10.1016/j.bbalip.2008.06.005	journal	September 2008
GPR35 is a novel lysophosphatidic acid receptor Oka, Saori; Ota, Ryo; Shima, Mitsuru Biochemical and Biophysical Research Communications, Vol. 395, Issue 2 https://doi.org/10.1016/j.bbrc.2010.03.169	journal	April 2010
Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Ishii, Shuhei; Hirane, Miku; Fukushima, Kaori Biochemical and Biophysical Research Communications, Vol. 461, Issue 1 https://doi.org/10.1016/j.bbrc.2015.03.169	journal	May 2015
Lysophosphatidic acid (LPA) signaling via LPA 4 and LPA 6 negatively regulates cell motile activities of colon cancer cells Takahashi, Kaede; Fukushima, Kaori; Onishi, Yuka Biochemical and Biophysical Research Communications, Vol. 483, Issue 1 https://doi.org/10.1016/j.bbrc.2016.12.088	journal	January 2017
Hallmarks of Cancer: The Next Generation Hanahan, Douglas; Weinberg, Robert A. Cell, Vol. 144, Issue 5 https://doi.org/10.1016/j.cell.2011.02.013	journal	March 2011
The Pan-ErbB Negative Regulator Lrig1 Is an Intestinal Stem Cell Marker that Functions as a Tumor Suppressor Powell, Anne E.; Wang, Yang; Li, Yina Cell, Vol. 149, Issue 1 https://doi.org/10.1016/j.cell.2012.02.042	journal	March 2012
Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells Vidot, Susanne; Witham, James; Agarwal, Roshan Cellular Signalling, Vol. 22, Issue 6 https://doi.org/10.1016/j.cellsig.2010.01.017	journal	June 2010
Specific increase in serum autotaxin activity in patients with pancreatic cancer Nakai, Yousuke; Ikeda, Hitoshi; Nakamura, Kazuhiro Clinical Biochemistry, Vol. 44, Issue 8-9 https://doi.org/10.1016/j.clinbiochem.2011.03.128	journal	June 2011
Structure–function relationships of autotaxin, a secreted lysophospholipase D Hausmann, Jens; Perrakis, Anastassis; Moolenaar, Wouter H. Advances in Biological Regulation, Vol. 53, Issue 1 https://doi.org/10.1016/j.jbior.2012.09.010	journal	January 2013
Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPARα/FGF21 Axis Qiu, Han; Song, Erfei; Hu, Yue Cellular and Molecular Gastroenterology and Hepatology, Vol. 14, Issue 5 https://doi.org/10.1016/j.jcmgh.2022.07.012	journal	January 2022
Gut barrier disruption and chronic disease Martel, Jan; Chang, Shih-Hsin; Ko, Yun-Fei Trends in Endocrinology & Metabolism, Vol. 33, Issue 4 https://doi.org/10.1016/j.tem.2022.01.002	journal	April 2022
Dual mode regulation of migration by lysophosphatidic acid in human gastric cancer cells Shida, Dai; Kitayama, Joji; Yamaguchi, Hironori Experimental Cell Research, Vol. 301, Issue 2 https://doi.org/10.1016/j.yexcr.2004.08.008	journal	December 2004
Non-transactivational, dual pathways for LPA-induced Erk1/2 activation in primary cultures of brown pre-adipocytes Holmström, Therese E.; Mattsson, Charlotte L.; Wang, Yanling Experimental Cell Research, Vol. 316, Issue 16 https://doi.org/10.1016/j.yexcr.2010.05.029	journal	October 2010
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway Blesen, Tim van; Hawes, Brian E.; Luttrell, Deirdre K. Nature, Vol. 376, Issue 6543 https://doi.org/10.1038/376781a0	journal	August 1995
Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors Daub, Henrik; Ulrich Weiss, F.; Wallasch, Christian Nature, Vol. 379, Issue 6565 https://doi.org/10.1038/379557a0	journal	February 1996
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF Prenzel, Norbert; Zwick, Esther; Daub, Henrik Nature, Vol. 402, Issue 6764 https://doi.org/10.1038/47260	journal	December 1999
Involvement of autotaxin/lysophospholipase D expression in intestinal vessels in aggravation of intestinal damage through lymphocyte migration Hozumi, Hideaki; Hokari, Ryota; Kurihara, Chie Laboratory Investigation, Vol. 93, Issue 5 https://doi.org/10.1038/labinvest.2013.45	journal	May 2013
Aberrant expression of lysophosphatidic acid (LPA) receptors in human colorectal cancer Shida, Dai; Watanabe, Toshiaki; Aoki, Junken Laboratory Investigation, Vol. 84, Issue 10 https://doi.org/10.1038/labinvest.3700146	journal	October 2004
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche Sato, Toshiro; Vries, Robert G.; Snippert, Hugo J. Nature, Vol. 459, Issue 7244 https://doi.org/10.1038/nature07935	journal	March 2009
A single-cell survey of the small intestinal epithelium Haber, Adam L.; Biton, Moshe; Rogel, Noga Nature, Vol. 551, Issue 7680 https://doi.org/10.1038/nature24489	journal	November 2017
Common variants at five new loci associated with early-onset inflammatory bowel disease Nature Genetics, Vol. 41, Issue 12 https://doi.org/10.1038/ng.489	journal	November 2009
G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth Pasternack, Sandra M.; von Kügelgen, Ivar; Aboud, Khalid Al Nature Genetics, Vol. 40, Issue 3 https://doi.org/10.1038/ng.84	journal	February 2008
Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs Kanda, Hidenobu; Newton, Rebecca; Klein, Russell Nature Immunology, Vol. 9, Issue 4 https://doi.org/10.1038/ni1573	journal	March 2008
Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies Geraldo, Luiz Henrique Medeiros; Spohr, Tânia Cristina Leite de Sampaio; Amaral, Rackele Ferreira do Signal Transduction and Targeted Therapy, Vol. 6, Issue 1 https://doi.org/10.1038/s41392-020-00367-5	journal	February 2021
The Agpat4/LPA axis in colorectal cancer cells regulates antitumor responses via p38/p65 signaling in macrophages Zhang, Dapeng; Shi, Rongchen; Xiang, Wei Signal Transduction and Targeted Therapy, Vol. 5, Issue 1 https://doi.org/10.1038/s41392-020-0117-y	journal	March 2020
Discovery of common and rare genetic risk variants for colorectal cancer Huyghe, Jeroen R.; Bien, Stephanie A.; Harrison, Tabitha A. Nature Genetics, Vol. 51, Issue 1 https://doi.org/10.1038/s41588-018-0286-6	journal	December 2018
EGFR signal transactivation in cancer cells Fischer, O. M.; Hart, S.; Gschwind, A. Biochemical Society Transactions, Vol. 31, Issue 6 https://doi.org/10.1042/bst0311203	journal	December 2003
Modulation of intestinal epithelial wound healing in vitro and in vivo by lysophosphatidic acid Sturm, Andreas; Sudermann, Thomas; Schulte, Klaus–Martin Gastroenterology, Vol. 117, Issue 2 https://doi.org/10.1053/gast.1999.0029900368	journal	August 1999
Lysophosphatidic Acid Stimulates the Intestinal Brush Border Na+/H+ Exchanger 3 and Fluid Absorption via LPA5 and NHERF2 Lin, Songbai; Yeruva, Sunil; He, Peijian Gastroenterology, Vol. 138, Issue 2 https://doi.org/10.1053/j.gastro.2009.09.055	journal	February 2010
Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus Kremer, Andreas E.; Martens, Job J. W. W.; Kulik, Wim Gastroenterology, Vol. 139, Issue 3 https://doi.org/10.1053/j.gastro.2010.05.009	journal	September 2010
Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation Albers, H. M. H. G.; Dong, A.; van Meeteren, L. A. Proceedings of the National Academy of Sciences, Vol. 107, Issue 16 https://doi.org/10.1073/pnas.1001529107	journal	April 2010
Characterization of a Novel Subtype of Human G Protein-coupled Receptor for Lysophosphatidic Acid An, Songzhu; Bleu, Thieu; Hallmark, Olivia G. Journal of Biological Chemistry, Vol. 273, Issue 14 https://doi.org/10.1074/jbc.273.14.7906	journal	April 1998
Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells Fulkerson, Zachary; Wu, Tao; Sunkara, Manjula Journal of Biological Chemistry, Vol. 286, Issue 40 https://doi.org/10.1074/jbc.M111.276725	journal	October 2011
Targeted Deletion of LPA5 Identifies Novel Roles for Lysophosphatidic Acid Signaling in Development of Neuropathic Pain Lin, Mu-En; Rivera, Richard R.; Chun, Jerold Journal of Biological Chemistry, Vol. 287, Issue 21 https://doi.org/10.1074/jbc.M111.330183	journal	May 2012
The Polybasic Insertion in Autotaxin α Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans Houben, Anna J. S.; van Wijk, Xander M. R.; van Meeteren, Laurens A. Journal of Biological Chemistry, Vol. 288, Issue 1 https://doi.org/10.1074/jbc.M112.358416	journal	January 2013
Regulation of Hypoxia-inducible Factor 1α (HIF-1α) by Lysophosphatidic Acid Is Dependent on Interplay between p53 and Krüppel-like Factor 5 Lee, Sei-Jung; No, Yi Ran; Dang, Duyen T. Journal of Biological Chemistry, Vol. 288, Issue 35 https://doi.org/10.1074/jbc.M113.489708	journal	August 2013
Autotaxin Is Released from Adipocytes, Catalyzes Lysophosphatidic Acid Synthesis, and Activates Preadipocyte Proliferation Ferry, Gilles; Tellier, Edwige; Try, Anne Journal of Biological Chemistry, Vol. 278, Issue 20 https://doi.org/10.1074/jbc.M301158200	journal	May 2003
Identification of p2y9/GPR23 as a Novel G Protein-coupled Receptor for Lysophosphatidic Acid, Structurally Distant from the Edg Family Noguchi, Kyoko; Ishii, Satoshi; Shimizu, Takao Journal of Biological Chemistry, Vol. 278, Issue 28 https://doi.org/10.1074/jbc.M302648200	journal	July 2003
Lysophosphatidic Acid (LPA) in Malignant Ascites Stimulates Motility of Human Pancreatic Cancer Cells through LPA1 Yamada, Takayuki; Sato, Koichi; Komachi, Mayumi Journal of Biological Chemistry, Vol. 279, Issue 8 https://doi.org/10.1074/jbc.M308133200	journal	February 2004
Identification of Residues Responsible for Ligand Recognition and Regioisomeric Selectivity of Lysophosphatidic Acid Receptors Expressed in Mammalian Cells Fujiwara, Yuko; Sardar, Vineet; Tokumura, Akira Journal of Biological Chemistry, Vol. 280, Issue 41 https://doi.org/10.1074/jbc.M504351200	journal	October 2005
Autotaxin Is Overexpressed in Glioblastoma Multiforme and Contributes to Cell Motility of Glioblastoma by Converting Lysophosphatidylcholine TO Lysophosphatidic Acid Kishi, Yasuhiro; Okudaira, Shinichi; Tanaka, Masayuki Journal of Biological Chemistry, Vol. 281, Issue 25 https://doi.org/10.1074/jbc.M601803200	journal	June 2006
Kynurenic Acid as a Ligand for Orphan G Protein-coupled Receptor GPR35 Wang, Jinghong; Simonavicius, Nicole; Wu, Xiaosu Journal of Biological Chemistry, Vol. 281, Issue 31 https://doi.org/10.1074/jbc.M603503200	journal	August 2006
GPR92 as a New G12/13- and Gq-coupled Lysophosphatidic Acid Receptor That Increases cAMP, LPA5 Lee, Chang-Wook; Rivera, Richard; Gardell, Shannon Journal of Biological Chemistry, Vol. 281, Issue 33 https://doi.org/10.1074/jbc.M603670200	journal	August 2006
Autotaxin Stabilizes Blood Vessels and Is Required for Embryonic Vasculature by Producing Lysophosphatidic Acid Tanaka, Masayuki; Okudaira, Shinichi; Kishi, Yasuhiro Journal of Biological Chemistry, Vol. 281, Issue 35 https://doi.org/10.1074/jbc.M605142200	journal	July 2006
Lysophosphatidic Acid Facilitates Proliferation of Colon Cancer Cells via Induction of Krüppel-like Factor 5 Zhang, Huanchun; Bialkowska, Agnieszka; Rusovici, Raluca Journal of Biological Chemistry, Vol. 282, Issue 21 https://doi.org/10.1074/jbc.M700702200	journal	May 2007
Autotaxin Expression in Hepatocellular Carcinoma Memet, Ilker; Tsalkidou, Evanthia; Tsaroucha, Alexandra K. Journal of Investigative Surgery, Vol. 31, Issue 5 https://doi.org/10.1080/08941939.2017.1331280	journal	June 2017
Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. Hecht, J. H.; Weiner, J. A.; Post, S. R. The Journal of cell biology, Vol. 135, Issue 4 https://doi.org/10.1083/jcb.135.4.1071	journal	November 1996
Lysophosphatidic acid inhibits cholera toxin-induced secretory diarrhea through CFTR-dependent protein interactions Li, Chunying; Dandridge, Keanna S.; Di, Anke The Journal of Experimental Medicine, Vol. 202, Issue 7 https://doi.org/10.1084/jem.20050421	journal	October 2005
Lysophosphatidic Acid is a Biomarker for Peritoneal Carcinomatosis of Gastric Cancer and Correlates with Poor Prognosis Zeng, Ruolan; Li, Bin; Huang, Junhui Genetic Testing and Molecular Biomarkers, Vol. 21, Issue 11 https://doi.org/10.1089/gtmb.2017.0060	journal	November 2017
Role of LPA₄/p2y9/GPR23 in Negative Regulation of Cell Motility Lee, Zendra; Cheng, Ching-Ting; Zhang, Helen Molecular Biology of the Cell, Vol. 19, Issue 12 https://doi.org/10.1091/mbc.e08-03-0316	journal	December 2008
LPA 1 receptors mediate stimulation, whereas LPA 2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites Komachi, Mayumi; Tomura, Hideaki; Malchinkhuu, Enkhzol Carcinogenesis, Vol. 30, Issue 3 https://doi.org/10.1093/carcin/bgp011	journal	January 2009
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling Stam, J. C.; Michiels, F.; van der Kammen, R. A. The EMBO Journal, Vol. 17, Issue 14 https://doi.org/10.1093/emboj/17.14.4066	journal	July 1998
Non-Edg family LPA receptors: the cutting edge of LPA research Yanagida, K.; Ishii, S. Journal of Biochemistry, Vol. 150, Issue 3 https://doi.org/10.1093/jb/mvr087	journal	July 2011
Lysophosphatidic Acid Binds to and Activates GPR92, a G Protein-Coupled Receptor Highly Expressed in Gastrointestinal Lymphocytes Kotarsky, Knut; Boketoft, Åke; Bristulf, Jesper Journal of Pharmacology and Experimental Therapeutics, Vol. 318, Issue 2 https://doi.org/10.1124/jpet.105.098848	journal	May 2006
Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis Bain, Gretchen; Shannon, Kristen E.; Huang, Fei Journal of Pharmacology and Experimental Therapeutics, Vol. 360, Issue 1 https://doi.org/10.1124/jpet.116.237156	journal	October 2016
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump Schneditz, Georg; Elias, Joshua E.; Pagano, Ester Science Signaling, Vol. 12, Issue 562 https://doi.org/10.1126/scisignal.aau9048	journal	January 2019
Distinct Phospholipase C-β Isozymes Mediate Lysophosphatidic Acid Receptor 1 Effects on Intestinal Epithelial Homeostasis and Wound Closure Lee, Sei-Jung; Leoni, Giovanna; Neumann, Philipp-Alexander Molecular and Cellular Biology, Vol. 33, Issue 10 https://doi.org/10.1128/MCB.00038-13	journal	May 2013
Autotaxin, a Secreted Lysophospholipase D, Is Essential for Blood Vessel Formation during Development van Meeteren, L. A.; Ruurs, P.; Stortelers, C. Molecular and Cellular Biology, Vol. 26, Issue 13 https://doi.org/10.1128/MCB.02419-05	journal	June 2006
NHERF2 Specifically Interacts with LPA₂ Receptor and Defines the Specificity and Efficiency of Receptor-Mediated Phospholipase C-β3 Activation Oh, Yong-Seok; Jo, Nam Won; Choi, Jung Woong Molecular and Cellular Biology, Vol. 24, Issue 11 https://doi.org/10.1128/MCB.24.11.5069-5079.2004	journal	June 2004
Lysophosphatidic acid 5 receptor induces activation of Na⁺/H⁺ exchanger 3 via apical epidermal growth factor receptor in intestinal epithelial cells Yoo, Byong Kwon; He, Peijian; Lee, Sei-Jung American Journal of Physiology-Cell Physiology, Vol. 301, Issue 5 https://doi.org/10.1152/ajpcell.00231.2011	journal	November 2011
LPA modulates monocyte migration directly and via LPA-stimulated endothelial cells Gustin, Cindy; Van Steenbrugge, Martine; Raes, Martine American Journal of Physiology-Cell Physiology, Vol. 295, Issue 4 https://doi.org/10.1152/ajpcell.00544.2007	journal	October 2008
LPA₂ receptor mediates mitogenic signals in human colon cancer cells Yun, C. Chris; Sun, Hong; Wang, Dongsheng American Journal of Physiology-Cell Physiology, Vol. 289, Issue 1 https://doi.org/10.1152/ajpcell.00610.2004	journal	July 2005
The absence of LPA receptor 2 reduces the tumorigenesis by Apc^Min mutation in the intestine Lin, Songbai; Lee, Sei-Jung; Shim, Hyunsuk American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 299, Issue 5 https://doi.org/10.1152/ajpgi.00321.2010	journal	November 2010
Mechanisms of lysophosphatidic acid (LPA) mediated stimulation of intestinal apical Cl⁻/OH⁻ exchange Singla, Amika; Dwivedi, Alka; Saksena, Seema American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 298, Issue 2 https://doi.org/10.1152/ajpgi.00345.2009	journal	February 2010
Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system Poole, Daniel P.; Lee, Mike; Tso, Patrick American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 306, Issue 8 https://doi.org/10.1152/ajpgi.00433.2013	journal	April 2014
Management of Pruritus in Chronic Liver Disease Bhalerao, Angeline; Mannu, Gurdeep S. Dermatology Research and Practice, Vol. 2015 https://doi.org/10.1155/2015/295891	journal	January 2015
Autotaxin Promotes Cancer Invasion via the Lysophosphatidic Acid Receptor 4: Participation of the Cyclic AMP/EPAC/Rac1 Signaling Pathway in Invadopodia Formation Harper, Kelly; Arsenault, Dominique; Boulay-Jean, Stephanie Cancer Research, Vol. 70, Issue 11 https://doi.org/10.1158/0008-5472.CAN-09-3813	journal	June 2010
Lysophosphatidic Acid Receptor LPAR6 Supports the Tumorigenicity of Hepatocellular Carcinoma Mazzocca, Antonio; Dituri, Francesco; De Santis, Flavia Cancer Research, Vol. 75, Issue 3 https://doi.org/10.1158/0008-5472.CAN-14-1607	journal	February 2015
Lysophosphatidic Acid Inhibits CD8 T-cell Activation and Control of Tumor Progression Oda, Shannon K.; Strauch, Pamela; Fujiwara, Yuko Cancer Immunology Research, Vol. 1, Issue 4 https://doi.org/10.1158/2326-6066.CIR-13-0043-T	journal	October 2013
Itch-Scratch Responses Induced by Lysophosphatidic Acid in Mice Hashimoto, Terumasa; Ohata, Hisayuki; Momose, Kazutaka Pharmacology, Vol. 72, Issue 1 https://doi.org/10.1159/000078632	journal	January 2004
Performance of autotaxin as a serum marker for liver fibrosis Ikeda, Hitoshi; Kobayashi, Mariko; Kumada, Hiromitsu Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, Vol. 55, Issue 4 https://doi.org/10.1177/0004563217741509	journal	November 2017
LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis Sumida, Hayakazu; Noguchi, Kyoko; Kihara, Yasuyuki Blood, Vol. 116, Issue 23 https://doi.org/10.1182/blood-2010-03-272443	journal	December 2010
Lysophosphatidic acid converts monocytes into macrophages in both mice and humans Ray, Rashmi; Rai, Vivek Blood, Vol. 129, Issue 9 https://doi.org/10.1182/blood-2016-10-743757	journal	March 2017
Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid Dusaulcy, Rodolphe; Rancoule, Chloé; Grès, Sandra Journal of Lipid Research, Vol. 52, Issue 6 https://doi.org/10.1194/jlr.M014985	journal	June 2011
Transgenic 6F tomatoes act on the small intestine to prevent systemic inflammation and dyslipidemia caused by Western diet and intestinally derived lysophosphatidic acid Navab, Mohamad; Hough, Greg; Buga, Georgette M. Journal of Lipid Research, Vol. 54, Issue 12 https://doi.org/10.1194/jlr.M042051	journal	December 2013
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate Benesch, Matthew G. K.; Zhao, Yuan Y.; Curtis, Jonathan M. Journal of Lipid Research, Vol. 56, Issue 6 https://doi.org/10.1194/jlr.M057661	journal	June 2015
Autotaxin: structure-function and signaling Perrakis, Anastassis; Moolenaar, Wouter H. Journal of Lipid Research, Vol. 55, Issue 6 https://doi.org/10.1194/jlr.R046391	journal	June 2014
LPA receptor signaling: pharmacology, physiology, and pathophysiology Yung, Yun C.; Stoddard, Nicole C.; Chun, Jerold Journal of Lipid Research, Vol. 55, Issue 7 https://doi.org/10.1194/jlr.R046458	journal	July 2014
Lipid phosphate phosphatases and signaling Brindley, David N.; Pilquil, Carlos Journal of Lipid Research, Vol. 50 https://doi.org/10.1194/jlr.R800055-JLR200	journal	April 2009
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D Jansen, Silvia; Stefan, Cristiana; Creemers, John W. M. Journal of Cell Science, Vol. 118, Issue 14 https://doi.org/10.1242/jcs.02438	journal	July 2005
Lysophosphatidic Acid Enhances In Vivo Infiltration and Activation of Guinea Pig Eosinophils and Neutrophils via a Rho/Rho-Associated Protein Kinase-Mediated Pathway Hashimoto, Terumasa; Yamashita, Miyuki; Ohata, Hisayuki Journal of Pharmacological Sciences, Vol. 91, Issue 1 https://doi.org/10.1254/jphs.91.8	journal	January 2003
LPA5 Is Abundantly Expressed by Human Mast Cells and Important for Lysophosphatidic Acid Induced MIP-1β Release Lundequist, Anders; Boyce, Joshua A. PLoS ONE, Vol. 6, Issue 3 https://doi.org/10.1371/journal.pone.0018192	journal	March 2011
CMTM8 as an LPA1-associated partner mediates lysophosphatidic acid-induced pancreatic cancer metastasis Shi, Weidong; Zhang, Chenyue; Ning, Zhouyu Annals of Translational Medicine, Vol. 9, Issue 1 https://doi.org/10.21037/atm-20-1013	journal	January 2021
GPR35 as a Novel Therapeutic Target MacKenzie, A. E.; Lappin, J. E.; Taylor, D. L. Frontiers in Endocrinology, Vol. 2 https://doi.org/10.3389/fendo.2011.00068	journal	January 2011
Coming of Age for Autotaxin and Lysophosphatidate Signaling: Clinical Applications for Preventing, Detecting and Targeting Tumor-Promoting Inflammation Benesch, Matthew; MacIntyre, Iain; McMullen, Todd Cancers, Vol. 10, Issue 3 https://doi.org/10.3390/cancers10030073	journal	March 2018
Compensatory Upregulation of LPA2 and Activation of the PI3K-Akt Pathway Prevent LPA5-Dependent Loss of Intestinal Epithelial Cells in Intestinal Organoids Liang, Zhongxing; Yun, C. Chris Cells, Vol. 11, Issue 14 https://doi.org/10.3390/cells11142243	journal	July 2022
Phospholipases A1 Richmond, Gregory S.; Smith, Terry K. International Journal of Molecular Sciences, Vol. 12, Issue 1 https://doi.org/10.3390/ijms12010588	journal	January 2011
Designing Dual Inhibitors of Autotaxin-LPAR GPCR Axis Banerjee, Souvik; Lee, Suechin; Norman, Derek D. Molecules, Vol. 27, Issue 17 https://doi.org/10.3390/molecules27175487	journal	August 2022
Autotaxin through Lysophosphatidic Acid Stimulates Polarization, Motility, and Transendothelial Migration of Naive T Cells Zhang, Yafeng; Chen, Yi-Chun Maria; Krummel, Matthew F. The Journal of Immunology, Vol. 189, Issue 8 https://doi.org/10.4049/jimmunol.1201604	journal	October 2012
Lysophosphatidic Acid Receptor 5 Inhibits B Cell Antigen Receptor Signaling and Antibody Response Hu, Jiancheng; Oda, Shannon K.; Shotts, Kristin The Journal of Immunology, Vol. 193, Issue 1 https://doi.org/10.4049/jimmunol.1300429	journal	July 2014
The Influence of Lysophosphatidic Acid on the Functions of Human Dendritic Cells Panther, Elisabeth; Idzko, Marco; Corinti, Silvia The Journal of Immunology, Vol. 169, Issue 8 https://doi.org/10.4049/jimmunol.169.8.4129	journal	October 2002

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