Reversible Binding Interfaces Made of Microstructured Polymer Brushes

Badenhorst, Ronaldo; Makaev, Sergei; Yaremchuk, Dmytro; Sajjan, Yash; Sulimov, Artem; Reukov, Vladimir V.; Lavrik, Nickolay V.; Ilnytskyi, Jaroslav; Minko, Sergiy

doi:10.1021/acs.langmuir.4c00062

Title: Reversible Binding Interfaces Made of Microstructured Polymer Brushes

Journal Article · 25 March 2024 · Langmuir

DOI: https://doi.org/10.1021/acs.langmuir.4c00062 · OSTI ID:2438657

Badenhorst, Ronaldo ^[1];

^[1]; Yaremchuk, Dmytro ^[2]; Sajjan, Yash ^[1]; Sulimov, Artem ^[1];

^[1]; Lavrik, Nickolay V. ^[3];

^[4];

^[1]

Univ. of Georgia, Athens, GA (United States)
National Academy of Sciences of Ukraine, Lviv (Ukraine)
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)
National Academy of Sciences of Ukraine, Lviv (Ukraine); Lviv Polytechnic National University (Ukraine)

The polymer brush architecture of the end-tethered polymer molecules is one of the most widely used efficient methods to regulate interfacial interactions in colloidal systems found in live matter and manufactured materials. Emerging applications of polymer brush structures require solutions to new tasks in the control of interfacial interactions. The rapid development of live cell manufacturing relies on scalable and efficient cell harvesting methods. Stimuli-responsive surfaces made of surface-grafted poly(N-isopropylacrylamide) (PNIPAM) can bind and detach the adherent cell upon changes in temperature and have been used for cell growth and harvesting. The applications are limited by the requirement to satisfy a range of PNIPAM coating characteristics that depend on the dimensions of the integrin complex in the cell membrane and the basal surface. The analysis of the microstructured surfaces, when adhesive and disjoining functions of the microdomains are decoupled, shows that many limitations of PNIPAM one-component coatings can be avoided by using a much broader range of structural characteristics of the microstructured interfaces composed of alternating disjoining PNIPAM domains and adhesive polymeric domains with cell-affinity functional groups. Temperature-controlled reversible adhesion to such microstructured interfaces is studied here experimentally with model systems of solid spherical particles and by employing simulations for solid and soft membranes interacting with the microstructured surfaces to mimic interactions with soft and solid disk-like particles.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF); National Science Foundation (NSF)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2438657

Journal Information:: Langmuir, Journal Name: Langmuir Journal Issue: 13 Vol. 40; ISSN 0743-7463

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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