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Title: Ketone monoester plus high‐dose glucose supplementation before exercise does not affect immediate post‐exercise erythropoietin concentrations versus glucose alone

Journal Article · · Physiological Reports
 [1];  [1];  [2]; ORCiD logo [3];  [4]; ORCiD logo [1]
  1. Military Nutrition Division U.S. Army Research Institute of Environmental Medicine (USARIEM) Natick Massachusetts USA
  2. Military Nutrition Division U.S. Army Research Institute of Environmental Medicine (USARIEM) Natick Massachusetts USA, Oak Ridge Institute for Science and Education Belcamp Maryland USA, Soldier Sustainment Directorate U.S. Army Combat Capabilities Development Command Soldier Center Natick Massachusetts USA
  3. Military Nutrition Division U.S. Army Research Institute of Environmental Medicine (USARIEM) Natick Massachusetts USA, Oak Ridge Institute for Science and Education Belcamp Maryland USA, Faculty of Kinesiology &, Physical Education University of Toronto Toronto Ontario Canada
  4. Soldier Effectiveness Directorate U.S. Army Combat Capabilities Development Command Soldier Center Natick Massachusetts USA
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Abstract The objective of this study was to examine the effect of consuming ketone monoester plus a high dose of carbohydrate from glucose (KE + CHO) on the change in erythropoietin (EPO) concentrations during load carriage exercise compared with carbohydrate (CHO) alone. Using a randomized, crossover design, 12 males consumed KE + CHO (573 mg KE/kg body mass, 110 g glucose) or CHO (110 g glucose) 30 min before 4 miles of self‐paced treadmill exercise (KE + CHO:51 ± 13%, CHO: 52 ± 12% V̇O 2peak ) wearing a weighted vest (30% body mass; 25 ± 3 kg). Blood samples for analysis were obtained under resting fasted conditions before (Baseline) consuming the KE + CHO or CHO supplement and immediately after exercise (Post). βHB increased ( p  < 0.05) from Baseline to Post in KE + CHO, with no change in CHO. Glucose and glycerol increased ( p  < 0.05) from Baseline to Post in CHO, with no effect of time in KE + CHO. Insulin and lactate increased ( p  < 0.05) from Baseline to Post independent of treatment. EPO increased ( p  < 0.05) from Baseline to Post in KE + CHO and CHO with no difference between treatments. Although KE + CHO altered βHB, glucose, and glycerol concentrations, results from this study suggest that KE + CHO supplementation before load carriage exercise does not enhance immediate post‐exercise increases in EPO compared with CHO alone.

Sponsoring Organization:
USDOE
OSTI ID:
2437830
Journal Information:
Physiological Reports, Journal Name: Physiological Reports Journal Issue: 16 Vol. 12; ISSN 2051-817X
Publisher:
Wiley-BlackwellCopyright Statement
Country of Publication:
United States
Language:
English

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