A magnetic‐directed micro‐particle with near‐ IR light triggered guest‐release property

Ge, Jin; Cheng, Xiang; Rong, Lihan; Cao, Peng‐Fei; Caldona, Eugene B.; Advincula, Rigoberto

doi:10.1002/app.56110

Title: A magnetic‐directed micro‐particle with near‐ IR light triggered guest‐release property

Journal Article · 22 August 2024 · Journal of Applied Polymer Science

DOI: https://doi.org/10.1002/app.56110 · OSTI ID:2437812

Ge, Jin ^[1]; Cheng, Xiang ^[1]; Rong, Lihan ^[1]; Cao, Peng‐Fei ^[2];

^[3];

^[4]

Department of Macromolecular Science and Engineering Case Western Reserve University Cleveland Ohio USA, Center for Nanophase Materials Sciences Oak Ridge National Laboratory Oak Ridge Tennessee USA
State Key Laboratory of Organic‐Inorganic Composites Beijing University of Chemical Technology Beijing China
Department of Coatings and Polymeric Materials North Dakota State University Fargo North Dakota USA
Department of Chemical and Biomolecular Engineering and Institute for Advanced Materials and Manufacturing University of Tennessee Knoxville Tennessee USA

Abstract In this study, guest carriers, composed of magnetic‐directed hydrogel particles with near‐infrared (NIR)‐light‐triggered guest‐release properties, are prepared via the one‐pot method. The gel particles contain photostable NIR‐responsive polypyrrole nanoparticles with temperature‐sensitive poly(N‐isopropyl acrylamide), the combination of which can induce the accelerated release of encapsulated drugs by 337% upon 5 minutes of NIR light irradiation based on the release profile of NRMG‐1 at 10–15 min. Additionally, with magnetic iron oxide particles crosslinking the polyvinyl alcohol frames, these gel particles can form a physical barrier that decreases the release rate by 20% under an external magnetic field over 24 h. The magnetic iron oxide particles also enable the gel particles to reach their target destination without extra drug losses.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2437812

Journal Information:: Journal of Applied Polymer Science, Journal Name: Journal of Applied Polymer Science Journal Issue: 42 Vol. 141; ISSN 0021-8995

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
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Title: A magnetic‐directed micro‐particle with near‐ IR light triggered guest‐release property

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