Title: US National Institutes of Health Prioritization of SARS-CoV-2 Variants

Journal Article · · Emerging Infectious Diseases
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  1. Univ. of Cambridge (United Kingdom)
  2. Univ. of California, Riverside, CA (United States)
  3. National Institutes of Health (NIH), Rockville, MD (United States)
  4. Ben Gurion Univ. of the Negev, Beer Sheva (Israel)
  5. Walter Reed Army Institute of Research, Silver Spring, MD (United States); Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Bethesda, MD (United States)
  6. Charité–Universitätsmedizin and German Center for Infection Research, Berlin (Germany)
  7. Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)
  8. Erasmus Medical Center, Rotterdam (Netherlands)
  9. Icahn School of Medicine at Mount Sinai, New York, NY (United States)
  10. Univ. of Missouri, Columbia, MO (United States)
  11. Univ. of Cambridge (United Kingdom); Charité–Universitätsmedizin and German Center for Infection Research, Berlin (Germany)
  12. Univ. of Wisconsin, Madison, WI (United States)
  13. Argonne National Laboratory (ANL), Argonne, IL (United States); Univ. of Chicago, IL (United States)
  14. J. Craig Venter Institute, Inc., La Jolla, MD (United States); Univ. of California, San Diego, CA (United States)
  15. J. Craig Venter Institute, Inc., La Jolla, MD (United States)
  16. Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Harvard Univ., Cambridge, MA (United States)
  17. J. Craig Venter Institute, Inc., La Jolla, CA (United States); Univ. of California, San Diego, CA (United States); La Jolla Institute for Immunology, CA (United States); Global Virus Network, Baltimore, MD (United States)
+ Show Author Affiliations

Since late 2020, SARS-CoV-2 variants have regularly emerged with competitive and phenotypic differences from previously circulating strains, sometimes with the potential to escape from immunity produced by prior exposure and infection. The Early Detection group is one of the constituent groups of the US National Institutes of Health National Institute of Allergy and Infectious Diseases SARS-CoV-2 Assessment of Viral Evolution program. Here, the group uses bioinformatic methods to monitor the emergence, spread, and potential phenotypic properties of emerging and circulating strains to identify the most relevant variants for experimental groups within the program to phenotypically characterize. Since April 2021, the group has prioritized variants monthly. Prioritization successes include rapidly identifying most major variants of SARS-CoV-2 and providing experimental groups within the National Institutes of Health program easy access to regularly updated information on the recent evolution and epidemiology of SARS-CoV-2 that can be used to guide phenotypic investigations.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
Centers for Disease Control and Prevention (CDC); National Institutes of Health (NIH); U.S. Army; USDOE Laboratory Directed Research and Development (LDRD) Program
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
2433839
Journal Information:
Emerging Infectious Diseases, Journal Name: Emerging Infectious Diseases Journal Issue: 5 Vol. 29; ISSN 1080-6040
Publisher:
Centers for Disease Control and Prevention (CDC)Copyright Statement
Country of Publication:
United States
Language:
English

References (9)

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus journal August 2020
HIV-1 and SARS-CoV-2: Patterns in the evolution of two pandemic pathogens journal July 2021
Comparative transmissibility of SARS-CoV-2 variants Delta and Alpha in New England, USA journal April 2022
Tracking cryptic SARS-CoV-2 lineages detected in NYC wastewater journal February 2022
A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology journal July 2020
The FoldX web server: an online force field journal July 2005
Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness journal June 2022
GISAID: Global initiative on sharing all influenza data – from vision to reality journal March 2017
Early detection of emerging SARS-CoV-2 variants of interest for experimental evaluation journal October 2022

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