Reproductive Factors and Endometrial Cancer Risk Among Women

Journal Article · 05 September 2023 · JAMA Network Open

DOI: https://doi.org/10.1001/jamanetworkopen.2023.32296 · OSTI ID:2424584

Katagiri, Ryoko ^[1]; Iwasaki, Motoki ^[2]; Abe, Sarah Krull ^[2]; Islam, Md. Rashedul ^[3]; Rahman, Md. Shafiur ^[4]; Saito, Eiko ^[5]; Merritt, Melissa A. ^[6]; Choi, Ji-Yeob ^[7]; Shin, Aesun ^[8]; Sawada, Norie ^[2]; Tamakoshi, Akiko ^[9]; Koh, Woon-Puay ^[10]; Sakata, Ritsu ^[11]; Tsuji, Ichiro ^[12]; Kim, Jeongseon ^[13]; Nagata, Chisato ^[14]; Park, Sue K. ^[15]; Kweon, Sun-Seog ^[16]; Shu, Xiao-Ou ^[17]; Gao, Yu-Tang ^[18] ; Tsugane, Shoichiro ^[2]; Kimura, Takashi ^[9]; Yuan, Jian-Min ^[19]; Kanemura, Seiki ^[12]; Lu, Yukai ^[12]; Sugawara, Yumi ^[12]; Wada, Keiko ^[14]; Shin, Min-Ho ^[16]; Ahsan, Habibul ^[20]; Boffetta, Paolo ^[21]; Chia, Kee Seng ^[22]; Matsuo, Keitaro ^[23]; Qiao, You-Lin ^[24]; Rothman, Nathaniel ^[25]; Zheng, Wei ^[17]; Inoue, Manami ^[2]; Kang, Daehee ^[15]

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1. National Cancer Center Institute for Cancer Control, Tokyo (Japan); National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo (Japan)
2. National Cancer Center Institute for Cancer Control, Tokyo (Japan)
3. National Cancer Center Institute for Cancer Control, Tokyo (Japan); Hitotsubashi University, Tokyo (Japan)
4. National Cancer Center Institute for Cancer Control, Tokyo (Japan); Hamamatsu University School of Medicine, Shizuoka (Japan)
5. National Center for Global Health and Medicine, Tokyo (Japan)
6. University of Sydney, New South Wales (Australia)
7. Seoul National University Graduate School (Korea)
8. Seoul National University (Korea); Seoul National University College of Medicine (Korea)
9. Hokkaido University Faculty of Medicine, Sapporo (Japan)
10. National University of Singapore (Singapore); Singapore Institute for Clinical Sciences (Singapore)
11. Radiation Effects Research Foundation, Hiroshima (Japan)
12. Tohoku University Graduate School of Medicine, Miyagi (Japan)
13. National Cancer Center, Goyang (Korea)
14. Gifu University Graduate School of Medicine (Japan)
15. Seoul National University College of Medicine (Korea)
16. Chonnam National University Medical School, Gwangju (Korea)
17. Vanderbilt University Medical Center, Nashville, TN (United States)
18. Shanghai Cancer Institute (China)
19. University of Pittsburgh, PA (United States)
20. University of Chicago, IL (United States)
21. Stony Brook University, NY (United States); University of Bologna (Italy)
22. National University of Singapore (Singapore)
23. Aichi Cancer Center Research Institute, Nagoya (Japan); Nagoya University Graduate School of Medicine (Japan)
24. Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing (China)
25. National Cancer Institute, Bethesda, MD (United States)

Despite evidence of an association between reproductive factors and endometrial cancer risk, prospective studies have been conducted mainly in non-Asian countries. To assess the association between reproductive factors, such as number of deliveries, age at menarche, or menopause, and endometrial cancer risk. This cohort study used pooled individual data from 13 prospective cohort studies conducted between 1963 and 2014 in the Asia Cohort Consortium. Participants were Asian women. Data analysis was conducted from September 2019 to April 2023. Reproductive factors were assessed using a questionnaire in each cohort. The main outcome was time to incidence of endometrial cancer. A Cox proportional hazards model was used to calculate hazard ratios (HRs) and 95% CIs.

• Research Organization: Radiation Effects Research Foundation (RERF), Hiroshima (Japan)
• Sponsoring Organization: USDOE
• OSTI ID: 2424584
• Journal Information: JAMA Network Open, Journal Name: JAMA Network Open Journal Issue: 9 Vol. 6; ISSN 2574-3805
• Publisher: American Medical AssociationCopyright Statement
• Country of Publication: United States
• Language: English