Simple Scattering: Lipid nanoparticle structural data repository

Kim, Lee Joon; Shin, David; Leite, Wellington C.; O’Neill, Hugh; Ruebel, Oliver; Tritt, Andrew; Hura, Greg L.

doi:10.3389/fmolb.2024.1321364

Title: Simple Scattering: Lipid nanoparticle structural data repository

Journal Article · 21 March 2024 · Frontiers in Molecular Biosciences

DOI: https://doi.org/10.3389/fmolb.2024.1321364 · OSTI ID:2375472

Kim, Lee Joon ^[1]; Shin, David ^[2]; Leite, Wellington C. ^[3]; O’Neill, Hugh ^[3]; Ruebel, Oliver ^[1]; Tritt, Andrew ^[1]; Hura, Greg L. ^[4]

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
David Shin Consulting, Berkeley, CA (United States)
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Univ. of California, Santa Cruz, CA (United States)

Lipid nanoparticles (LNPs) are being intensively researched and developed to leverage their ability to safely and effectively deliver therapeutics. To achieve optimal therapeutic delivery, a comprehensive understanding of the relationship between formulation, structure, and efficacy is critical. However, the vast chemical space involved in the production of LNPs and the resulting structural complexity make the structure to function relationship challenging to assess and predict. New components and formulation procedures, which provide new opportunities for the use of LNPs, would be best identified and optimized using high-throughput characterization methods. Recently, a high-throughput workflow, consisting of automated mixing, small-angle X-ray scattering (SAXS), and cellular assays, demonstrated a link between formulation, internal structure, and efficacy for a library of LNPs. As SAXS data can be rapidly collected, the stage is set for the collection of thousands of SAXS profiles from a myriad of LNP formulations. In addition, correlated LNP small-angle neutron scattering (SANS) datasets, where components are systematically deuterated for additional contrast inside, provide complementary structural information. The centralization of SAXS and SANS datasets from LNPs, with appropriate, standardized metadata describing formulation parameters, into a data repository will provide valuable guidance for the formulation of LNPs with desired properties. To this end, we introduce Simple Scattering, an easy-to-use, open data repository for storing and sharing groups of correlated scattering profiles obtained from LNP screening experiments. Here, we discuss the current state of the repository, including limitations and upcoming changes, and our vision towards future usage in developing our collective knowledge base of LNPs.

View Accepted Manuscript (DOE)

Cite

Export

Save

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: National Institute of Health (NIH); USDOE Office of Science (SC), Advanced Scientific Computing Research (ASCR); USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: AC02-05CH11231; AC05-00OR22725

OSTI ID:: 2375472

Journal Information:: Frontiers in Molecular Biosciences, Journal Name: Frontiers in Molecular Biosciences Vol. 11; ISSN 2296-889X

Publisher:: Frontiers Media S.A.Copyright Statement

Country of Publication:: United States

Language:: English

References (71)

Coupling Lipid Nanoparticle Structure and Automated Single‐Particle Composition Analysis to Design Phospholipase‐Responsive Nanocarriers Barriga, Hanna M. G.; Pence, Isaac J.; Holme, Margaret N. Advanced Materials, Vol. 34, Issue 26 https://doi.org/10.1002/adma.202200839	journal	May 2022
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency Cheng, Miffy Hok Yan; Leung, Jerry; Zhang, Yao Advanced Materials, Vol. 35, Issue 31 https://doi.org/10.1002/adma.202303370	journal	June 2023
Cubosomes: The Next Generation of Smart Lipid Nanoparticles? Barriga, Hanna M. G.; Holme, Margaret N.; Stevens, Molly M. Angewandte Chemie International Edition, Vol. 58, Issue 10 https://doi.org/10.1002/anie.201804067	journal	March 2019
Real‐Time pH‐Dependent Self‐Assembly of Ionisable Lipids from COVID‐19 Vaccines and In Situ Nucleic Acid Complexation Yu, Haitao; Angelova, Angelina; Angelov, Borislav Angewandte Chemie International Edition, Vol. 62, Issue 35 https://doi.org/10.1002/anie.202304977	journal	July 2023
SASBDB: Towards an automatically curated and validated repository for biological scattering data Kikhney, Alexey G.; Borges, Clemente R.; Molodenskiy, Dmitry S. Protein Science, Vol. 29, Issue 1 https://doi.org/10.1002/pro.3731	journal	October 2019
LIPIDAT: A database of lipid phase transition temperatures and enthalpy changes. DMPC data subset analysis Caffrey, Martin; Hogan, Jacqueline Chemistry and Physics of Lipids, Vol. 61, Issue 1 https://doi.org/10.1016/0009-3084(92)90002-7	journal	March 1992
Visualizing and accessing correlated SAXS data sets with Similarity Maps and Simple Scattering web resources Murray, Daniel T.; Shin, David S.; Classen, Scott Small Angle Scattering Part B: Methods for Structural Interpretation https://doi.org/10.1016/bs.mie.2022.09.024	book	November 2022
The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery Cheng, Xinwei; Lee, Robert J. Advanced Drug Delivery Reviews, Vol. 99 https://doi.org/10.1016/j.addr.2016.01.022	journal	April 2016
Self-assembled mRNA vaccines Kim, Jeonghwan; Eygeris, Yulia; Gupta, Mohit Advanced Drug Delivery Reviews, Vol. 170 https://doi.org/10.1016/j.addr.2020.12.014	journal	March 2021
Encapsulation state of messenger RNA inside lipid nanoparticles Brader, Mark L.; Williams, Sean J.; Banks, Jessica M. Biophysical Journal, Vol. 120, Issue 14 https://doi.org/10.1016/j.bpj.2021.03.012	journal	July 2021
Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents Angelova, Angelina; Garamus, Vasil M.; Angelov, Borislav Advances in Colloid and Interface Science, Vol. 249 https://doi.org/10.1016/j.cis.2017.04.006	journal	November 2017
Self-assembled stable sponge-type nanocarries for Brucea javanica oil delivery Zou, Aihua; Li, Yawen; Chen, Yiyin Colloids and Surfaces B: Biointerfaces, Vol. 153 https://doi.org/10.1016/j.colsurfb.2017.02.031	journal	May 2017
Automated high-throughput preparation and characterization of oligonucleotide-loaded lipid nanoparticles Fan, Yuchen; Yen, Chun-Wan; Lin, Hsiu-Chao International Journal of Pharmaceutics, Vol. 599 https://doi.org/10.1016/j.ijpharm.2021.120392	journal	April 2021
Comparison of cubosomes and hexosomes for the delivery of phenytoin to the brain Mohammad, Younus; Prentice, Richard N.; Boyd, Ben J. Journal of Colloid and Interface Science, Vol. 605 https://doi.org/10.1016/j.jcis.2021.07.070	journal	January 2022
Cubosomal lipid nanoassemblies with pH-sensitive shells created by biopolymer complexes: A synchrotron SAXS study Mathews, Patrick D.; Mertins, Omar; Angelov, Borislav Journal of Colloid and Interface Science, Vol. 607 https://doi.org/10.1016/j.jcis.2021.08.187	journal	February 2022
Impact of lipid nanoparticle size on mRNA vaccine immunogenicity Hassett, Kimberly J.; Higgins, Jaclyn; Woods, Angela Journal of Controlled Release, Vol. 335 https://doi.org/10.1016/j.jconrel.2021.05.021	journal	July 2021
Structural analysis of nanoparticulate carriers for encapsulation of macromolecular drugs Angelov, Borislav; Garamus, Vasil M.; Drechsler, Markus Journal of Molecular Liquids, Vol. 235 https://doi.org/10.1016/j.molliq.2016.11.064	journal	June 2017
Saposin Lipid Nanoparticles: A Highly Versatile and Modular Tool for Membrane Protein Research Flayhan, Ali; Mertens, Haydyn D. T.; Ural-Blimke, Yonca Structure, Vol. 26, Issue 2 https://doi.org/10.1016/j.str.2018.01.007	journal	February 2018
Cubosomes and Hexosomes as Novel Nanocarriers for Bioactive Compounds Tan, Chen; Hosseini, Seyed Fakhreddin; Jafari, Seid Mahdi Journal of Agricultural and Food Chemistry, Vol. 70, Issue 5 https://doi.org/10.1021/acs.jafc.1c06747	journal	January 2022
Change in Morphology of Dimyristoylphosphatidylcholine/Bile Salt Derivative Bicelle Assemblies with Dodecylmaltoside in the Disk and Ribbon Phases Leite, Wellington C.; Wu, Yuqi; Pingali, Sai Venkatesh The Journal of Physical Chemistry Letters, Vol. 13, Issue 42 https://doi.org/10.1021/acs.jpclett.2c02445	journal	October 2022
Characterizing an siRNA-Containing Lipid-Nanoparticle Prepared by a Microfluidic Reactor: Small-Angle X-ray Scattering and Cryotransmission Electron Microscopic Studies Aburai, Kenichi; Hatanaka, Kentaro; Takano, Shin Langmuir, Vol. 36, Issue 42 https://doi.org/10.1021/acs.langmuir.0c01079	journal	September 2020
Investigation of pH-Responsiveness inside Lipid Nanoparticles for Parenteral mRNA Application Using Small-Angle X-ray Scattering Uebbing, Lukas; Ziller, Antje; Siewert, Christian Langmuir, Vol. 36, Issue 44 https://doi.org/10.1021/acs.langmuir.0c02446	journal	October 2020
Water Content in Nanoparticles Determined by Small-Angle Neutron Scattering and Light Scattering Kangarlou, Behrad; Hoy, Donyeil; Scott, Haden L. Langmuir, Vol. 39, Issue 1 https://doi.org/10.1021/acs.langmuir.2c02420	journal	December 2022
Structural Characterization Study of a Lipid Nanocapsule Formulation Intended for Drug Delivery Applications Using Small-Angle Scattering Techniques Urimi, Dileep; Hellsing, Maja; Mahmoudi, Najet Molecular Pharmaceutics, Vol. 19, Issue 4 https://doi.org/10.1021/acs.molpharmaceut.1c00648	journal	February 2022
Process Robustness in Lipid Nanoparticle Production: A Comparison of Microfluidic and Turbulent Jet Mixing O’Brien Laramy, Matthew N.; Costa, Antonio P.; Cebrero, Yareli Maciel Molecular Pharmaceutics, Vol. 20, Issue 8 https://doi.org/10.1021/acs.molpharmaceut.3c00390	journal	July 2023
Poly(N-vinylpyrrolidone)-block-Poly(dimethylsiloxane)-block-Poly(N-vinylpyrrolidone) Triblock Copolymer Polymersomes for Delivery of PARP1 siRNA to Breast Cancers Yang, Yiming; Kozlovskaya, Veronika; Zhang, Zhuo ACS Applied Bio Materials, Vol. 5, Issue 4 https://doi.org/10.1021/acsabm.2c00063	journal	March 2022
Polysarcosine-Functionalized Lipid Nanoparticles for Therapeutic mRNA Delivery Nogueira, Sara S.; Schlegel, Anne; Maxeiner, Konrad ACS Applied Nano Materials, Vol. 3, Issue 11 https://doi.org/10.1021/acsanm.0c01834	journal	September 2020
Apolipoprotein E Binding Drives Structural and Compositional Rearrangement of mRNA-Containing Lipid Nanoparticles Sebastiani, Federica; Yanez Arteta, Marianna; Lerche, Michael ACS Nano, Vol. 15, Issue 4 https://doi.org/10.1021/acsnano.0c10064	journal	March 2021
Lipid Nanoparticles─From Liposomes to mRNA Vaccine Delivery, a Landscape of Research Diversity and Advancement Tenchov, Rumiana; Bird, Robert; Curtze, Allison E. ACS Nano, Vol. 15, Issue 11 https://doi.org/10.1021/acsnano.1c04996	journal	June 2021
Acidification-Induced Structure Evolution of Lipid Nanoparticles Correlates with Their In Vitro Gene Transfections Li, Zongyi; Carter, Jessica; Santos, Luis ACS Nano, Vol. 17, Issue 2 https://doi.org/10.1021/acsnano.2c06213	journal	January 2023
Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering Hammel, Michal; Fan, Yuchen; Sarode, Apoorva ACS Nano, Vol. 17, Issue 12 https://doi.org/10.1021/acsnano.3c01186	journal	June 2023
Morphological Characterization of Self-Amplifying mRNA Lipid Nanoparticles Thelen, Jacob L.; Leite, Wellington; Urban, Volker S. ACS Nano, Vol. 18, Issue 2 https://doi.org/10.1021/acsnano.3c08014	journal	January 2024
On the Formation and Morphology of Lipid Nanoparticles Containing Ionizable Cationic Lipids and siRNA Kulkarni, Jayesh A.; Darjuan, Maria M.; Mercer, Joanne E. ACS Nano, Vol. 12, Issue 5 https://doi.org/10.1021/acsnano.8b01516	journal	April 2018
Non-Lamellar Lyotropic Liquid Crystalline Lipid Nanoparticles for the Next Generation of Nanomedicine Zhai, Jiali; Fong, Celesta; Tran, Nhiem ACS Nano, Vol. 13, Issue 6 https://doi.org/10.1021/acsnano.8b07961	journal	May 2019
Hexosomes as Efficient Platforms for Possible Fluoxetine Hydrochloride Repurposing with Improved Cytotoxicity against HepG2 Cells Abdel-Bar, Hend Mohamed; Khater, Shaymaa Elsayed; Ghorab, Dalia Mahmoud ACS Omega, Vol. 5, Issue 41 https://doi.org/10.1021/acsomega.0c03569	journal	October 2020
Liquid Crystalline Nanostructures as PEGylated Reservoirs of Omega-3 Polyunsaturated Fatty Acids: Structural Insights toward Delivery Formulations against Neurodegenerative Disorders Angelova, Angelina; Drechsler, Markus; Garamus, Vasil M. ACS Omega, Vol. 3, Issue 3 https://doi.org/10.1021/acsomega.7b01935	journal	March 2018
Self-Assembled Multicompartment Liquid Crystalline Lipid Carriers for Protein, Peptide, and Nucleic Acid Drug Delivery Angelova, Angelina; Angelov, Borislav; Mutafchieva, Rada Accounts of Chemical Research, Vol. 44, Issue 2 https://doi.org/10.1021/ar100120v	journal	February 2011
Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation Chen, Delai; Love, Kevin T.; Chen, Yi Journal of the American Chemical Society, Vol. 134, Issue 16 https://doi.org/10.1021/ja301621z	journal	April 2012
Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core Leung, Alex K. K.; Hafez, Ismail M.; Baoukina, Svetlana The Journal of Physical Chemistry C, Vol. 116, Issue 34 https://doi.org/10.1021/jp303267y	journal	August 2012
DNA/Fusogenic Lipid Nanocarrier Assembly: Millisecond Structural Dynamics Angelov, Borislav; Angelova, Angelina; Filippov, Sergey K. The Journal of Physical Chemistry Letters, Vol. 4, Issue 11 https://doi.org/10.1021/jz400857z	journal	May 2013
Multicompartment Lipid Cubic Nanoparticles with High Protein Upload: Millisecond Dynamics of Formation Angelov, Borislav; Angelova, Angelina; Filippov, Sergey K. ACS Nano, Vol. 8, Issue 5 https://doi.org/10.1021/nn5012946	journal	April 2014
Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics Maier, Martin A.; Jayaraman, Muthusamy; Matsuda, Shigeo Molecular Therapy, Vol. 21, Issue 8 https://doi.org/10.1038/mt.2013.124	journal	August 2013
Influence of Polyethylene Glycol Lipid Desorption Rates on Pharmacokinetics and Pharmacodynamics of siRNA Lipid Nanoparticles Mui, Barbara L.; Tam, Ying K.; Jayaraman, Muthusamy Molecular Therapy - Nucleic Acids, Vol. 2 https://doi.org/10.1038/mtna.2013.66	journal	January 2013
Overcoming cellular barriers for RNA therapeutics Dowdy, Steven F. Nature Biotechnology, Vol. 35, Issue 3 https://doi.org/10.1038/nbt.3802	journal	February 2017
Robust, high-throughput solution structural analyses by small angle X-ray scattering (SAXS) Hura, Greg L.; Menon, Angeli L.; Hammel, Michal Nature Methods, Vol. 6, Issue 8 https://doi.org/10.1038/nmeth.1353	journal	July 2009
Comprehensive macromolecular conformations mapped by quantitative SAXS analyses Hura, Greg L.; Budworth, Helen; Dyer, Kevin N. Nature Methods, Vol. 10, Issue 6 https://doi.org/10.1038/nmeth.2453	journal	April 2013
Non-viral vectors for gene-based therapy Yin, Hao; Kanasty, Rosemary L.; Eltoukhy, Ahmed A. Nature Reviews Genetics, Vol. 15, Issue 8 https://doi.org/10.1038/nrg3763	journal	July 2014
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA Patel, Siddharth; Ashwanikumar, N.; Robinson, Ema Nature Communications, Vol. 11, Issue 1 https://doi.org/10.1038/s41467-020-14527-2	journal	February 2020
DeepRank: a deep learning framework for data mining 3D protein-protein interfaces Renaud, Nicolas; Geng, Cunliang; Georgievska, Sonja Nature Communications, Vol. 12, Issue 1 https://doi.org/10.1038/s41467-021-27396-0	journal	December 2021
The Onpattro story and the clinical translation of nanomedicines containing nucleic acid-based drugs Akinc, Akin; Maier, Martin A.; Manoharan, Muthiah Nature Nanotechnology, Vol. 14, Issue 12 https://doi.org/10.1038/s41565-019-0591-y	journal	December 2019
Highly accurate protein structure prediction with AlphaFold Jumper, John; Evans, Richard; Pritzel, Alexander Nature https://doi.org/10.1038/s41586-021-03819-2	journal	July 2021
Deciphering interaction fingerprints from protein molecular surfaces using geometric deep learning Gainza, P.; Sverrisson, F.; Monti, F. Nature Methods, Vol. 17, Issue 2 https://doi.org/10.1038/s41592-019-0666-6	journal	December 2019
Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration Carrasco, Manuel J.; Alishetty, Suman; Alameh, Mohamad-Gabriel Communications Biology, Vol. 4, Issue 1 https://doi.org/10.1038/s42003-021-02441-2	journal	August 2021
Sterically stabilized spongosomes for multidrug delivery of anticancer nanomedicines Chen, Yiyin; Angelova, Angelina; Angelov, Borislav Journal of Materials Chemistry B, Vol. 3, Issue 39 https://doi.org/10.1039/C5TB01193K	journal	January 2015
Predictive high-throughput screening of PEGylated lipids in oligonucleotide-loaded lipid nanoparticles for neuronal gene silencing Sarode, Apoorva; Fan, Yuchen; Byrnes, Amy E. Nanoscale Advances, Vol. 4, Issue 9 https://doi.org/10.1039/d1na00712b	journal	January 2022
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults Anderson, Evan J.; Rouphael, Nadine G.; Widge, Alicia T. New England Journal of Medicine, Vol. 383, Issue 25 https://doi.org/10.1056/NEJMoa2028436	journal	December 2020
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine Polack, Fernando P.; Thomas, Stephen J.; Kitchin, Nicholas New England Journal of Medicine, Vol. 383, Issue 27 https://doi.org/10.1056/NEJMoa2034577	journal	December 2020
Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles Yanez Arteta, Marianna; Kjellman, Tomas; Bartesaghi, Stefano Proceedings of the National Academy of Sciences, Vol. 115, Issue 15 https://doi.org/10.1073/pnas.1720542115	journal	March 2018
CORAL: A framework for rigorous self-validated data modeling and integrative, reproducible data analysis Novichkov, Pavel S.; Chandonia, John-Marc; Arkin, Adam P. GigaScience, Vol. 11 https://doi.org/10.1093/gigascience/giac089	journal	October 2022
LMSD: LIPID MAPS structure database Sud, M.; Fahy, E.; Cotter, D. Nucleic Acids Research, Vol. 35, Issue Database https://doi.org/10.1093/nar/gkl838	journal	January 2007
The worldwide Protein Data Bank (wwPDB): ensuring a single, uniform archive of PDB data Berman, H.; Henrick, K.; Nakamura, H. Nucleic Acids Research, Vol. 35, Issue Database https://doi.org/10.1093/nar/gkl971	journal	January 2007
Accurate prediction of protein structures and interactions using a three-track neural network Baek, Minkyung; DiMaio, Frank; Anishchenko, Ivan Science, Vol. 373, Issue 6557 https://doi.org/10.1126/science.abj8754	journal	July 2021
Design and Characterization of Novel Peptide-Coated Lipid Nanoparticles for Targeting Anti-HIV Drug to CD4 Expressing Cells Endsley, Aaron N.; Ho, Rodney J. Y. The AAPS Journal, Vol. 14, Issue 2 https://doi.org/10.1208/s12248-012-9329-6	journal	March 2012
The effects of PEGylation on LNP based mRNA delivery to the eye Ryals, Renee C.; Patel, Siddharth; Acosta, Chris PLOS ONE, Vol. 15, Issue 10 https://doi.org/10.1371/journal.pone.0241006	journal	October 2020
Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization Ball, Rebecca; Bajaj, Palak; Whitehead, Kathryn International Journal of Nanomedicine, Vol. Volume 12 https://doi.org/10.2147/IJN.S123062	journal	December 2016
Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance Yao, Yihan; Zhou, Yunxiang; Liu, Lihong Frontiers in Molecular Biosciences, Vol. 7 https://doi.org/10.3389/fmolb.2020.00193	journal	August 2020
Cubosomes in Drug Delivery—A Comprehensive Review on Its Structural Components, Preparation Techniques and Therapeutic Applications Sivadasan, Durgaramani; Sultan, Muhammad H.; Alqahtani, Saad S. Biomedicines, Vol. 11, Issue 4 https://doi.org/10.3390/biomedicines11041114	journal	April 2023
Polysarcosine-Functionalized mRNA Lipid Nanoparticles Tailored for Immunotherapy Wilhelmy, Christoph; Keil, Isabell Sofia; Uebbing, Lukas Pharmaceutics, Vol. 15, Issue 8 https://doi.org/10.3390/pharmaceutics15082068	journal	August 2023
Small Angle X-ray and Neutron Scattering: Powerful Tools for Studying the Structure of Drug-Loaded Liposomes Di Cola, Emanuela; Grillo, Isabelle; Ristori, Sandra Pharmaceutics, Vol. 8, Issue 2 https://doi.org/10.3390/pharmaceutics8020010	journal	March 2016
Lipid-Based Nanoparticles in the Clinic and Clinical Trials: From Cancer Nanomedicine to COVID-19 Vaccines Thi, Thai Thanh Hoang; Suys, Estelle J. A.; Lee, Jung Seok Vaccines, Vol. 9, Issue 4 https://doi.org/10.3390/vaccines9040359	journal	April 2021
The Neurodata Without Borders ecosystem for neurophysiological data science Rübel, Oliver; Tritt, Andrew; Ly, Ryan eLife, Vol. 11 https://doi.org/10.7554/eLife.78362	journal	October 2022

Similar Records

Exploring the impact of nucleotide length on lipid nanoparticle structure and properties

Journal Article · 2026 · International Journal of Pharmaceutics · OSTI ID:3367508

Hammel, Michal; Fan, Yuchen; Kim, Lee Joon; +5 more

Structural and mechanical properties of cardiolipin lipid bilayers determined using neutron spin echo, small angle neutron and X-ray scattering, and molecular dynamics simulations

Journal Article · 2014 · Soft Matter · OSTI ID:1286806

Pan, Jianjun; Cheng, Xiaolin; Sharp, Melissa; +3 more

Alternative Structural Lipids Impact mRNA-Lipid Nanoparticle Morphology, Stability, and Activity

Journal Article · 2025 · Molecular Pharmaceutics · OSTI ID:3576303

Thorn, Chelsea R.; Hickey, James Collin; Chi, Ying-Chih; +7 more

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
SAS
database
lipid nanoparticles
small-angle scattering
structure-activity relationship
vaccines
web application

Title: Simple Scattering: Lipid nanoparticle structural data repository

Citation Formats

References (71)

Similar Records

Related Subjects