The Efficacy and Safety of an Intra-articular Dual-Acting Antibacterial Agent (TNP-2092) for Implant Infection–Associated Methicillin-Resistant Staphylococcus aureus

Journal Article · 25 December 2023 · Journal of Infectious Diseases

DOI: https://doi.org/10.1093/infdis/jiad588 · OSTI ID:2373316

Dai, Tianyu; Ma, Chi; Zhang, Fan; Wang, Hui ; Ma, Zhenkun; Wang, Huan; Wen, Yinxian; Chen, Liaobin

Abstract Owing to the presence of microbial biofilm on the implant, the eradication of biofilm-associated infections poses a challenge for antibiotic therapies. The study aimed to investigate the efficacy and safety of the novel antibiotic agent TNP-2092 in the context of implant infections. In vivo, rats with periprosthetic joint infection (PJI) treated with antibiotics showed an increase in body weight and decrease in swelling, temperature, and width of knee, compared with the control group. Meanwhile, inflammatory markers in synovium and serum were decreased in the TNP-2092 group, consistent with the pathological results. Moreover, TNP-2092 was effective in eliminating bacteria and disruption biofilm formation, and further alleviated the abnormal bone absorption and reactive bone changes around the prosthesis. In conclusion, intra-articular injection of TNP-2092 is safe and effective in treating knee PJI in a rat model. The study provides a foundation for the future utilization of TNP-2092 in the management of implant-related infections.

• Sponsoring Organization: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research
• OSTI ID: 2373316
• Journal Information: Journal of Infectious Diseases, Journal Name: Journal of Infectious Diseases Journal Issue: 6 Vol. 229; ISSN 0022-1899
• Publisher: Oxford University PressCopyright Statement
• Country of Publication: United States
• Language: English