Dynamics of ER stress-induced gene regulation in plants

Ko, Dae Kwan; Brandizzi, Federica

doi:10.1038/s41576-024-00710-4

Title: Dynamics of ER stress-induced gene regulation in plants

Journal Article · 17 March 2024 · Nature Reviews. Genetics

DOI: https://doi.org/10.1038/s41576-024-00710-4 · OSTI ID:2370469

^[1];

^[2]

Michigan State University, East Lansing, MI (United States); Michigan State University Department of Plant Biology
Michigan State University, East Lansing, MI (United States)

Endoplasmic reticulum (ER) stress is a potentially lethal condition that is induced by the abnormal accumulation of unfolded or misfolded secretory proteins in the ER. In eukaryotes, ER stress is managed by the unfolded protein response (UPR) through a tightly regulated, yet highly dynamic, reprogramming of gene transcription. Although the core principles of the UPR are similar across eukaryotes, unique features of the plant UPR reflect the adaptability of plants to their ever-changing environments and the need to balance the demands of growth and development with the response to environmental stressors. Here, the past decades have seen notable progress in understanding the mechanisms underlying ER stress sensing and signaling transduction pathways, implicating the UPR in the effects of physiological and induced ER stress on plant growth and crop yield. Facilitated by sequencing technologies and advances in genetic and genomic resources, recent efforts have driven the discovery of transcriptional regulators and elucidated the mechanisms that mediate the dynamic and precise gene regulation in response to ER stress at the systems level.

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Research Organization:: Great Lakes Bioenergy Research Center (GLBRC), Madison, WI (United States); Michigan State University, East Lansing, MI (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER); USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division (CSGB)

Grant/Contract Number:: SC0018409; FG02-91ER20021

OSTI ID:: 2370469

Journal Information:: Nature Reviews. Genetics, Journal Name: Nature Reviews. Genetics Vol. 25; ISSN 1471-0056

Publisher:: Springer NatureCopyright Statement

Country of Publication:: United States

Language:: English

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