Microbiome processing of organic nitrogen input supports growth and cyanotoxin production of Microcystis aeruginosa cultures

Li, Wei; Baliu-Rodriguez, David; Premathilaka, Sanduni H.; Thenuwara, Sharmila I.; Kimbrel, Jeffrey A.; Samo, Ty J.; Ramon, Christina; Kiledal, Erik Anders; Rivera, Sara R.; Kharbush, Jenan; Isailovic, Dragan; Weber, Peter K.; Dick, Gregory J.; Mayali, Xavier

doi:10.1093/ismejo/wrae082

Title: Microbiome processing of organic nitrogen input supports growth and cyanotoxin production of Microcystis aeruginosa cultures

Journal Article · 07 May 2024 · The ISME Journal

DOI: https://doi.org/10.1093/ismejo/wrae082 · OSTI ID:2361184

Li, Wei; Baliu-Rodriguez, David; Premathilaka, Sanduni H.; Thenuwara, Sharmila I.; Kimbrel, Jeffrey A.; Samo, Ty J.; Ramon, Christina; Kiledal, Erik Anders; Rivera, Sara R.; Kharbush, Jenan; Isailovic, Dragan; Weber, Peter K.; Dick, Gregory J.; Mayali, Xavier

Abstract Nutrient-induced blooms of the globally abundant freshwater toxic cyanobacterium Microcystis cause worldwide public and ecosystem health concerns. The response of Microcystis growth and toxin production to new and recycled nitrogen (N) inputs and the impact of heterotrophic bacteria in the Microcystis phycosphere on these processes are not well understood. Here, using microbiome transplant experiments, cyanotoxin analysis, and nanometer-scale stable isotope probing to measure N incorporation and exchange at single cell resolution, we monitored the growth, cyanotoxin production, and microbiome community structure of several Microcystis strains grown on amino acids or proteins as the sole N source. We demonstrate that the type of organic N available shaped the microbial community associated with Microcystis, and external organic N input led to decreased bacterial colonization of Microcystis colonies. Our data also suggest that certain Microcystis strains could directly uptake amino acids, but with lower rates than heterotrophic bacteria. Toxin analysis showed that biomass-specific microcystin production was not impacted by N source (i.e. nitrate, amino acids, or protein) but rather by total N availability. Single-cell isotope incorporation revealed that some bacterial communities competed with Microcystis for organic N, but other communities promoted increased N uptake by Microcystis, likely through ammonification or organic N modification. Our laboratory culture data suggest that organic N input could support Microcystis blooms and toxin production in nature, and Microcystis-associated microbial communities likely play critical roles in this process by influencing cyanobacterial succession through either decreasing (via competition) or increasing (via biotransformation) N availability, especially under inorganic N scarcity.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 2361184

Alternate ID(s):: OSTI ID: 2371784

Journal Information:: The ISME Journal, Journal Name: The ISME Journal Journal Issue: 1 Vol. 18; ISSN 1751-7362

Publisher:: Oxford University PressCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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