Electrochemical Amyloid β Immunosensor Based on Ti₃C₂T_x MXene Nanosheets

Journal Article · 24 July 2024 · Microscopy and Microanalysis

DOI: https://doi.org/10.1093/mam/ozae044.459 · OSTI ID:2348858

Garcia, Antonio S. ^[1]; Locke, Angelina K. ^[2]; Core, Bryson D. ^[2]; Gautam, Bhoj R. ^[2]; Autrey, Daniel E. ^[2]; Han, Shubo ^[2]

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1. Fayetteville State University, NC (United States); Fayetteville State University
2. Fayetteville State University, NC (United States)

Alzheimer’s disease (AD) is the most common neurodegenerative disease and a major health-care problem. More than 55 million people in the world, including 6.7 million Americans, are living with AD. As AD is characterized by production and deposition of β-amyloid peptide (Aβ) in the brain, Aβ is considered as a potential biomarker for diagnosing and monitoring the progression of AD. Nanomaterials-based electrochemical immunosensor is one of the most promising methods for early diagnosis and therapeutic of AD, due to its highly selective, sensitive, and label-free advantages. The graphene-like two-dimensional (2D) MXene nanosheets have shown large surface area, good conductivity, biocompatibility, high ion transport, and low diffusion barrier, attracting attention in recent years to use it as the nanomaterial substrate for biosensor fabrication. In this paper, we presented a Ti₃C₂T_x MXene nanosheets-based electrochemical immunosensor to detect trace Aβ for early diagnosis of AD.

• Research Organization: Fayetteville State University, NC (United States)
• Sponsoring Organization: USDOE Office of Science (SC), Basic Energy Sciences (BES)
• Grant/Contract Number: SC0024611
• OSTI ID: 2348858
• Journal Information: Microscopy and Microanalysis, Journal Name: Microscopy and Microanalysis Journal Issue: Supplement_1 Vol. 30; ISSN 1431-9276
• Publisher: Microscopy Society of America (MSA)Copyright Statement
• Country of Publication: United States
• Language: English