Neutrophils in pancreatic ductal adenocarcinoma: bridging preclinical insights to clinical prospects for improved therapeutic strategies

Jin, Yi; Christenson, Eric S.; Zheng, Lei; Li, Keyu

doi:10.1080/1744666X.2024.2348605

Title: Neutrophils in pancreatic ductal adenocarcinoma: bridging preclinical insights to clinical prospects for improved therapeutic strategies

Journal Article · 07 May 2024 · Expert Review of Clinical Immunology

DOI: https://doi.org/10.1080/1744666X.2024.2348605 · OSTI ID:2345098

Jin, Yi ^[1]; Christenson, Eric S. ^[2]; Zheng, Lei ^[3]; Li, Keyu ^[4]

Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Pancreatic Cancer Precision Medicine Center of Excellence Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA
The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Pancreatic Cancer Precision Medicine Center of Excellence Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Pancreatic Cancer Precision Medicine Center of Excellence Program, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine, Baltimore, MD, USA, The Skip Viragh Pancreatic Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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Sponsoring Organization:: USDOE Office of Electricity (OE), Advanced Grid Research & Development. Power Systems Engineering Research

Grant/Contract Number:: 2023YFS0167

OSTI ID:: 2345098

Journal Information:: Expert Review of Clinical Immunology, Journal Name: Expert Review of Clinical Immunology Vol. 20 Journal Issue: 8; ISSN 1744-666X

Publisher:: Informa UK LimitedCopyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

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Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial Shaw, Alice T.; Felip, Enriqueta; Bauer, Todd M. The Lancet Oncology, Vol. 18, Issue 12 https://doi.org/10.1016/S1470-2045(17)30680-0	journal	December 2017
Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer Zhang, Yu; Chandra, Vidhi; Riquelme Sanchez, Erick Journal of Experimental Medicine, Vol. 217, Issue 12 https://doi.org/10.1084/jem.20190354	journal	August 2020
Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead Che, Jinxin; Song, Rui; Chen, Binhui European Journal of Medicinal Chemistry, Vol. 185 https://doi.org/10.1016/j.ejmech.2019.111853	journal	January 2020
Intraductal papillary mucinous neoplasm (IPMN) with high-grade dysplasia is a risk factor for the subsequent development of pancreatic ductal adenocarcinoma Rezaee, Neda; Barbon, Carlotta; Zaki, Ahmed HPB, Vol. 18, Issue 3 https://doi.org/10.1016/j.hpb.2015.10.010	journal	March 2016
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease Lood, Christian; Blanco, Luz P.; Purmalek, Monica M. Nature Medicine, Vol. 22, Issue 2 https://doi.org/10.1038/nm.4027	journal	January 2016
Periodontitis pathogen Porphyromonas gingivalis promotes pancreatic tumorigenesis via neutrophil elastase from tumor-associated neutrophils Tan, Qin; Ma, Xiao; Yang, Bing Gut Microbes, Vol. 14, Issue 1 https://doi.org/10.1080/19490976.2022.2073785	journal	May 2022
Neutrophil intrinsic and extrinsic regulation of NETosis in health and disease Poli, Valentina; Zanoni, Ivan Trends in Microbiology, Vol. 31, Issue 3 https://doi.org/10.1016/j.tim.2022.10.002	journal	March 2023
Neutrophil diversity and plasticity in tumour progression and therapy Jaillon, Sebastien; Ponzetta, Andrea; Di Mitri, Diletta Nature Reviews Cancer, Vol. 20, Issue 9 https://doi.org/10.1038/s41568-020-0281-y	journal	July 2020
PF-06463922, an ALK/ROS1 Inhibitor, Overcomes Resistance to First and Second Generation ALK Inhibitors in Preclinical Models Zou, Helen Y.; Friboulet, Luc; Kodack, David P. Cancer Cell, Vol. 28, Issue 1 https://doi.org/10.1016/j.ccell.2015.05.010	journal	July 2015
Chronic pancreatitis, pancreatic adenocarcinoma and the black box in-between Jura, Natalia; Archer, Herbert; Bar-Sagi, Dafna Cell Research, Vol. 15, Issue 1 https://doi.org/10.1038/sj.cr.7290269	journal	January 2005
Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation Tape, Christopher J.; Ling, Stephanie; Dimitriadi, Maria Cell, Vol. 165, Issue 7 https://doi.org/10.1016/j.cell.2016.05.079	journal	June 2016
Tissue inhibitor of metalloproteinases (TIMP)‐1 creates a premetastatic niche in the liver through SDF‐1/CXCR4‐dependent neutrophil recruitment in mice Seubert, Bastian; Grünwald, Barbara; Kobuch, Julia Hepatology, Vol. 61, Issue 1 https://doi.org/10.1002/hep.27378	journal	November 2014
Tumor-associated neutrophils induce apoptosis of non-activated CD8 T-cells in a TNFα and NO-dependent mechanism, promoting a tumor-supportive environment Michaeli, Janna; Shaul, Merav E.; Mishalian, Inbal OncoImmunology, Vol. 6, Issue 11 https://doi.org/10.1080/2162402X.2017.1356965	journal	August 2017
Neutrophil plasticity in the tumor microenvironment Giese, Morgan A.; Hind, Laurel E.; Huttenlocher, Anna Blood, Vol. 133, Issue 20 https://doi.org/10.1182/blood-2018-11-844548	journal	May 2019
Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: A transcriptomics analysis of pro- vs. antitumor TANs Shaul, Merav E.; Levy, Liran; Sun, Jing OncoImmunology, Vol. 5, Issue 11 https://doi.org/10.1080/2162402X.2016.1232221	journal	September 2016
The CXCR4 antagonist 4F-benzoyl-TN14003 stimulates the recovery of the bone marrow after transplantation Abraham, M.; Beider, K.; Wald, H. Leukemia, Vol. 23, Issue 8 https://doi.org/10.1038/leu.2009.56	journal	March 2009

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