Biocompatible Co–P Metallic Glasses with Superior Degradation Tolerance in Physiological Environments

Pole, Mayur; Man, Kun; Mahajan, Chaitanya; Jha, Shristy; Yang, Yong; Mukherjee, Sundeep

doi:10.1021/acsabm.3c00844

Title: Biocompatible Co–P Metallic Glasses with Superior Degradation Tolerance in Physiological Environments

Journal Article · 28 December 2023 · ACS Applied Bio Materials

DOI: https://doi.org/10.1021/acsabm.3c00844 · OSTI ID:2345021

Pole, Mayur ^[1];

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^[2]; Jha, Shristy ^[2];

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Univ. of North Texas, Denton, TX (United States); Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Univ. of North Texas, Denton, TX (United States)

Metallic glasses represent a class of metallic alloys with a fully amorphous structure and attractive properties, making them promising in bioimplant applications. Here, the degradation tolerance of biocompatible cobalt–phosphorus (Co–P) metallic glasses was studied in a simulated physiological environment. The metallic glasses were synthesized in the form of coatings through a facile electrodeposition approach. This method utilizes their outstanding surface characteristics and bypasses the size limitations usually associated with their bulk counterparts. Further, the Co–P alloys showed exceptional tribological response with ~14% lower coefficient of friction and 2 orders of magnitude lesser wear rate compared to SS316 stainless steel. In addition, the Co–P alloys showed a 3 times higher hardness and 4 times higher hardness/modulus ratio compared to SS316, indicating better elastic recovery under dynamic shear stresses that are common in load-bearing bioimplants. The Co–P metallic glasses exhibited excellent hemocompatibility and cytocompatibility in terms of lower platelet adhesion, spreading, and aggregation, a hemolysis ratio lower than 1%, and enhanced surface wettability, suggesting a superlative performance in bioimplant applications.

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2345021

Report Number(s):: PNNL-SA--179844

Journal Information:: ACS Applied Bio Materials, Journal Name: ACS Applied Bio Materials Journal Issue: 1 Vol. 7; ISSN 2576-6422

Publisher:: ACS PublicationsCopyright Statement

Country of Publication:: United States

Language:: English

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36 MATERIALS SCIENCE
biocompatibility
electrodeposition
friction
hemocompatible
metallic glass
wear

Title: Biocompatible Co–P Metallic Glasses with Superior Degradation Tolerance in Physiological Environments

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