DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Deciphering Tumor Cell Evolution in Cutaneous T-Cell Lymphomas: Distinct Differentiation Trajectories in Mycosis Fungoides and Sézary Syndrome

Journal Article · · Journal of Investigative Dermatology

Not Available

Sponsoring Organization:
USDOE Energy Information Administration (EIA), Office of Energy Analysis
OSTI ID:
2338204
Journal Information:
Journal of Investigative Dermatology, Journal Name: Journal of Investigative Dermatology Journal Issue: 5 Vol. 144; ISSN 0022-202X
Publisher:
ElsevierCopyright Statement
Country of Publication:
United States
Language:
English

References (68)

A Validated Regulatory Network for Th17 Cell Specification journal October 2012
Dupilumab therapy in Sézary syndrome misdiagnosed as atopic dermatitis: A case report journal July 2020
Oncogenomic analysis of mycosis fungoides reveals major differences with Sézary syndrome journal January 2009
TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL journal October 2015
Targeted RNA sequencing enhances gene expression profiling of ultra-low input samples journal June 2020
Spatial reconstruction of single-cell gene expression data journal April 2015
CD158k Is a Reliable Marker for Diagnosis of Sézary Syndrome and Reveals an Unprecedented Heterogeneity of Circulating Malignant Cells journal January 2015
Single-cell analysis of childhood leukemia reveals a link between developmental states and ribosomal protein expression as a source of intra-individual heterogeneity journal May 2020
Xenograft and cell culture models of Sézary syndrome reveal cell of origin diversity and subclonal heterogeneity journal October 2020
Distinct gene expression profiles of human type 1 and type 2 T helper cells journal June 2001
Cell-surface CD74 initiates a signaling cascade leading to cell proliferation and survival journal June 2006
The Akaike information criterion: Background, derivation, properties, application, interpretation, and refinements journal March 2019
Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma journal September 2019
Sézary's Reticulosis journal January 1964
Mycosis fungoides shows concurrent deregulation of multiple genes involved in the TNF signaling pathway: an expression profile study journal August 2003
PLCG1 mutations in cutaneous T-cell lymphomas journal March 2014
Anti-apoptotic function of Xbp1 as an IL-3 signaling molecule in hematopoietic cells journal February 2011
The mutational landscape of cutaneous T cell lymphoma and Sézary syndrome journal November 2015
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository journal January 2002
Development of Sézary syndrome following the administration of dupilumab journal January 2020
Single-Cell Lymphocyte Heterogeneity in Advanced Cutaneous T-cell Lymphoma Skin Tumors journal July 2019
Synthetic spike-in standards for RNA-seq experiments journal August 2011
Heterogeneous Abnormalities of CCND1 and RB1 in Primary Cutaneous T-Cell Lymphomas Suggesting Impaired Cell Cycle Control in Disease Pathogenesis journal June 2006
Single-Cell Profiling of Cutaneous T-Cell Lymphoma Reveals Underlying Heterogeneity Associated with Disease Progression journal May 2019
Single-cell mRNA quantification and differential analysis with Census journal January 2017
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells journal March 2014
The measurement of diversity in different types of biological collections journal December 1966
A Comparative Study of Polymerase Chain Reaction Detection of Clonal T-cell Receptor Gamma Chain Gene Rearrangements Using Polyacrylamide Gel Electrophoresis versus Fluorescence Capillary Electrophoresis journal January 2008
Dupilumab Treatment in Two Patients with Cutaneous T-cell Lymphomas journal January 2020
The 2018 update of the WHO-EORTC classification for primary cutaneous lymphomas journal April 2019
Lesional gene expression profiling in cutaneous T-cell lymphoma reveals natural clusters associated with disease outcome journal October 2007
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics journal June 2018
Comprehensive Integration of Single-Cell Data journal June 2019
Clonotypic Diversity of the T-cell Receptor Corroborates the Immature Precursor Origin of Cutaneous T-cell Lymphoma journal May 2019
Circulating and skin-derived Sézary cells: clonal but with phenotypic plasticity journal September 2017
A Shannon entropy analysis of immunoglobulin and T cell receptor journal October 1997
Genetic rearrangements result in altered gene expression and novel fusion transcripts in Sézary syndrome journal April 2017
The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok journal January 2019
Quantitative PCR on 5 genes reliably identifies CTCL patients with 5% to 99% circulating tumor cells with 90% accuracy journal April 2006
New Insights Into the Complex Mutational Landscape of Sézary Syndrome journal April 2020
Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E) journal September 2017
Human skin is protected by four functionally and phenotypically discrete populations of resident and recirculating memory T cells journal March 2015
Sézary syndrome and mycosis fungoides arise from distinct T-cell subsets: a biologic rationale for their distinct clinical behaviors journal August 2010
Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice journal July 1998
TIAF1 self-aggregation in peritumor capsule formation, spontaneous activation of SMAD-responsive promoter in p53-deficient environment, and cell death journal April 2012
The Comparison of Two Single-cell Sequencing Platforms: BD Rhapsody and 10x Genomics Chromium journal December 2020
Mycosis Fungoides Exhibits a Th1-Type Cell-Mediated Cytokine Profile Whereas Sezary Syndrome Express a Th2-Type Profile journal July 1994
Single-cell heterogeneity in Sézary syndrome journal August 2018
CD48-deficient mice have a pronounced defect in CD4+T cell activation journal February 1999
The evolution of clonality testing in the diagnosis and monitoring of hematological malignancies journal February 2014
Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes journal November 2015
Two opposite signaling outputs are driven by the KIR2DL1 receptor in human CD4+ T cells journal September 2008
Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing journal March 2015
A Mathematical Theory of Communication journal July 1948
CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes journal February 2020
Interleukin-7 is a growth factor for Sézary lymphoma cells. journal September 1992
Comprehensive assessment of T-cell receptor β-chain diversity in αβ T cells journal November 2009
Essential role of TNF receptor superfamily 25 (TNFRSF25) in the development of allergic lung inflammation journal April 2008
Regulation of split anergy in natural killer cells by inhibition of cathepsins C and H and cystatin F journal June 2015
Survival Outcomes and Prognostic Factors in Mycosis Fungoides/Sézary Syndrome: Validation of the Revised International Society for Cutaneous Lymphomas/European Organisation for Research and Treatment of Cancer Staging Proposal journal November 2010
Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome journal June 2016
Branched evolution and genomic intratumor heterogeneity in the pathogenesis of cutaneous T-cell lymphoma journal June 2020
Immunodiagnosis in cutaneous T cell lymphoma: how does gene expression of the variable region of the T cell receptor fit into the diagnostic and pathophysiological picture of T cell neoplasia journal February 1992
Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories journal May 2021
Multimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures journal October 2021
Evaluation of Immunophenotypic and Molecular Biomarkers for Sézary Syndrome Using Standard Operating Procedures: A Multicenter Study of 59 Patients journal July 2016
T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides journal August 2015
Rapid and sustained control of itch and reduction in Th2 bias by dupilumab in a patient with Sézary syndrome journal November 2020