Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®

Hammami, Imen; Graça, Manuel Pedro Fernandes; Gavinho, Sílvia Rodrigues; Jakka, Suresh Kumar; Borges, João Paulo; Silva, Jorge Carvalho; Costa, Luís Cadillon

doi:10.3390/biomimetics9040213

Title: Exploring the Impact of Copper Oxide Substitution on Structure, Morphology, Bioactivity, and Electrical Properties of 45S5 Bioglass®

Journal Article · 02 April 2024 · Biomimetics

DOI: https://doi.org/10.3390/biomimetics9040213 · OSTI ID:2332916

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In recent decades, the requirements for implantable medical devices have increased, but the risks of implant rejection still exist. These issues are primarily associated with poor osseointegration, leading to biofilm formation on the implant surface. This study focuses on addressing these issues by developing a biomaterial for implant coatings. 45S5 bioglass® has been widely used in tissue engineering due to its ability to form a hydroxyapatite layer, ensuring a strong bond between the hard tissue and the bioglass. In this context, 45S5 bioglasses®, modified by the incorporation of different amounts of copper oxide, from 0 to 8 mol%, were synthesized by the melt–quenching technique. The incorporation of Cu ions did not show a significant change in the glass structure. Since the bioglass exhibited the capacity for being polarized, thereby promoting the osseointegration effectiveness, the electrical properties of the prepared samples were studied using the impedance spectroscopy method, in the frequency range of 102–106 Hz and temperature range of 200–400 K. The effects of CuO on charge transport mobility were investigated. Additionally, the bioactivity of the modified bioglasses was evaluated through immersion tests in simulated body fluid. The results revealed the initiation of a Ca–P-rich layer formation on the surface within 24 h, indicating the potential of the bioglasses to enhance the bone regeneration process.

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Sponsoring Organization:: USDOE Office of Energy Efficiency and Renewable Energy (EERE), Transportation Office. Fuel Cell Technologies Office

Grant/Contract Number:: SFRH/BD/148233/2019

OSTI ID:: 2332916

Journal Information:: Biomimetics, Journal Name: Biomimetics Vol. 9 Journal Issue: 4; ISSN 2313-7673

Publisher:: MDPI AGCopyright Statement

Country of Publication:: Switzerland

Language:: English

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