Native Mass Spectrometry Dissects the Structural Dynamics of an Allosteric Heterodimer of SARS-CoV-2 Nonstructural Proteins

Thibert, Stephanie M.; Reid, Deseree J.; Wilson, Jesse W.; Varikoti, Rohith; Maltseva, Natalia; Schultz, Katherine J.; Kruel, Agustin; Babnigg, Gyorgy; Joachimiak, Andrzej; Kumar, Neeraj; Zhou, Mowei

doi:10.1021/jasms.3c00453

Title: Native Mass Spectrometry Dissects the Structural Dynamics of an Allosteric Heterodimer of SARS-CoV-2 Nonstructural Proteins

Journal Article · 26 March 2024 · Journal of the American Society for Mass Spectrometry

DOI: https://doi.org/10.1021/jasms.3c00453 · OSTI ID:2329351

Thibert, Stephanie M. ^[1]; Reid, Deseree J. ^[2];

^[1]; Varikoti, Rohith ^[3]; Maltseva, Natalia ^[4]; Schultz, Katherine J. ^[3];

^[3];

^[5]; Joachimiak, Andrzej ^[4];

^[3];

^[1]

Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99354, United States
Chemical and Biological Signature Sciences, Pacific Northwest National Laboratory, Richland, Washington 99354, United States
Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99354, United States
Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60637, United States, Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Argonne, Illinois 60439, United States
Center for Structural Biology of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60637, United States, Biosciences Division, Argonne National Laboratory, Argonne, Illinois 60439, United States

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Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); Zhejiang Univ., Hangzhou (China)

Sponsoring Organization:: USDOE; USDOE Laboratory Directed Research and Development (LDRD) Program; USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE--Environmental Molecular Sciences Laboratory

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2329351

Report Number(s):: PNNL-SA-189769

Journal Information:: Journal of the American Society for Mass Spectrometry, Journal Name: Journal of the American Society for Mass Spectrometry Journal Issue: 5 Vol. 35; ISSN 1044-0305

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Title: Native Mass Spectrometry Dissects the Structural Dynamics of an Allosteric Heterodimer of SARS-CoV-2 Nonstructural Proteins

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