Biophotonic rogue waves in red blood cell suspensions

Ren, Yu-Xuan; Lamstein, Joshua; Zhang, Chensong; Conti, Claudio; Christodoulides, Demetrios N.; Chen, Zhigang

doi:10.1364/prj.496013

Title: Biophotonic rogue waves in red blood cell suspensions

Journal Article · 16 October 2023 · Photonics Research

DOI: https://doi.org/10.1364/prj.496013 · OSTI ID:2328199

^[1]; Lamstein, Joshua ^[2]; Zhang, Chensong ^[3];

^[4]; Christodoulides, Demetrios N. ^[5];

^[6]

Fudan University, Shanghai (China); San Francisco State University, CA (United States)
San Francisco State University, CA (United States); Gladstone Institutes, San Francisco, CA (United States)
San Francisco State University, CA (United States); SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States). Stanford Synchrotron Radiation Lightsource (SSRL)
University Sapienza, Rome (Italy)
University of Southern California, Los Angeles, CA (United States)
San Francisco State University, CA (United States); Nankai University, Tianjin (China)

Rogue waves are ubiquitous in nature, appearing in a variety of physical systems ranging from acoustics, microwave cavities, optical fibers, and resonators to plasmas, superfluids, and Bose–Einstein condensates. Unlike nonlinear solitary waves, rogue waves are extreme events that can occur even without nonlinearity by, for example, spontaneous synchronization of waves with different spatial frequencies in a linear system. Here, we report the observation of rogue-wave-like events in human red blood cell (RBC) suspensions under weak light illumination, characterized by an abnormal L-shaped probability distribution. Such biophotonic extreme events arise mostly due to the constructive interference of Mie-scattered waves from the suspended RBCs, whose biconcave shape and mutable orientation give rise to a time-dependent random phase modulation to an incident laser beam. We numerically simulate the beam propagation through the colloidal suspensions with added disorder in both spatial and temporal domains to mimic random scattering due to Brownian motion. In addition, at high power levels, nonlinear beam self-focusing is also observed, leading to a dual-exponential probability distribution associated with the formation of multiple soliton-like spots. Such rogue wave events should also exist in environments with cells of other species such as swimming bacteria, and understanding of their underlying physics may lead to unexpected biophotonic applications.

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Research Organization:: SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-76SF00515

OSTI ID:: 2328199

Journal Information:: Photonics Research, Vol. 11, Issue 11; ISSN 2327-9125

Publisher:: Optical Society of America (OSA)Copyright Statement

Country of Publication:: United States

Language:: English

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